A5068544225- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Hematopoietic Stem Cell Transplantation
- CAR-T cell therapy research
- Adrenal and Paraganglionic Tumors
- Chronic Lymphocytic Leukemia Research
- Primary Care and Health Outcomes
- Cancer, Hypoxia, and Metabolism
- Healthcare innovation and challenges
- Particle Detector Development and Performance
- Geriatric Care and Nursing Homes
- Interprofessional Education and Collaboration
- Palliative Care and End-of-Life Issues
- Eosinophilic Disorders and Syndromes
- Immune cells in cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Particle physics theoretical and experimental studies
- Particle Accelerators and Free-Electron Lasers
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Healthcare Quality and Management
- Lymphoma Diagnosis and Treatment
Johns Hopkins Hospital
2022-2025
Johns Hopkins University
2014-2025
Sidney Kimmel Comprehensive Cancer Center
2015-2024
Sidney Kimmel Cancer Center
2019-2024
University of East Anglia
2022-2024
Johns Hopkins Medicine
2021-2023
Indiana University
2022
University School
2022
Indiana University School of Medicine
2022
Indiana University – Purdue University Indianapolis
2022
Cabergoline is a long-acting dopamine-agonist drug that suppresses prolactin secretion and restores gonadal function in women with hyperprolactinemic amenorrhea. We designed study to compare its safety efficacy those of bromocriptine, which has been the standard therapy.A total 459 amenorrhea were treated either cabergoline (0.5 1.0 mg twice weekly) or bromocriptine (2.5 5.0 daily), administered double-blind fashion for 8 weeks subsequently an open 16 weeks, during adjustments dose made...
This book is grounded in the ‘real world’. It centred on a practice perspective and there are links throughout to clinical setting. The preface captures challenges that many qualitative researchers face when being encouraged adopt quantitative approach by supervisors or funders of research. Chris Bassett clearly passionate about approaches research, which evident writing will help engage reader.
Abstract Immune suppression, exhaustion, and senescence are frequently seen throughout disease progression in acute myeloid leukemia (AML). We conducted a phase II study of high-dose cytarabine followed by pembrolizumab 200 mg i.v. on day 14 to examine whether PD-1 inhibition improves clinical responses relapsed/refractory (R/R) AML. Overall responders could receive maintenance up 2 years. Among 37 patients enrolled, the overall response rate, composite complete remission (CRc) rate (primary...
Leukemia inhibitory factor (LIF) gene expression was detected in human fetal pituitary tissue by of LIF mRNA transcripts, protein immunocytochemistry, and immunoelectron microscopy. Fetal immunoreactivity colocalized with 30% ACTH-expressing cells, approximately 20% somatotrophs, 15% non-hormone-expressing cells. also strongly expressed normal adult four growth hormone-producing two ACTH-producing adenomas, but not eight nonfunctioning tumors. Culture cells expressing surface LIF-binding...
Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, ranging from molar pregnancy to choriocarcinoma. Patients with persistent require treatment chemotherapy. For the vast majority, prognosis excellent. Occasionally, GTD complicated by hyperthyroidism, which may treatment. This thought occur due molecular mimicry between human chorionic gonadotrophin (HCG) and thyroid-stimulating hormone (TSH), hence cross-reactivity TSH receptor. Hyperthyroidism usually resolves as...
Abstract While digital health solutions continue to grow in number and complexity, the ability for stakeholders healthcare easily discern quality lags far behind. This challenge is part due lack of a transparent standardized approach validation. Evaluation mobile applications (apps) further burdened by low barriers development direct-to-user marketing, leading crowded confusing landscape. In this context, we investigated pragmatic application previously described framework validation,...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for acute lymphoblastic leukemia (ALL) provide recommendations management of ALL, with a focus on the classification ALL subtypes based immunophenotype and cytogenetic/molecular markers; risk assessment stratification risk-adapted therapy; treatment strategies Philadelphia chromosome (Ph)-positive Ph-negative both adolescent young adult patients; supportive care considerations. This selection from focuses adults newly...
Asparaginase (ASNase)-based chemotherapy regimens significantly improve survival outcomes in children, adolescent and young adult (AYA), even adults with acute lymphoblastic leukemia/lymphoma (ALL); however, the incidence severity of ASNase-associated adverse events (AEs) may differ from those reported children. Strategies to mitigate, monitor for, manage toxicities that allow ALL patients receive full ASNase courses are needed. A representative 12-member panel experts who treat AYA...
Background: The excess mortality and morbidity associated with acromegaly are secondary to prolonged elevation of GH IGF-I. Vigorous control these biochemical parameters results in improved mortality. Somatostatin analogues (SAs) allow adequate IGF-I approximately 65% subjects, leaving a significant cohort uncontrolled. Dopamine agonists (DAs), cheap alternative SAs, less than 20% patients acromegaly. Aims: To assess the effectiveness adding DA therapy SA Subjects: One hundred twenty cases...
Purpose Hospitalized patients with cancer are considered to be at high risk for venous thromboembolism (VTE). Despite strong recommendations in numerous clinical practice guidelines, retrospective studies have shown that pharmacologic thromboprophylaxis is underutilized hospitalized cancer. Patients and Methods We conducted a prospective, cross-sectional study of five academic hospitals determine prescription rates factors influencing its use during hospitalization. Results A total 775 were...
We describe outcomes after post-transplantation cyclophosphamide and nonmyeloablative conditioning-based allogeneic blood or marrow transplantation for myelofibrosis using matched mismatched related unrelated donors. The conditioning regimen consisted of fludarabine, cyclophosphamide, total body irradiation. Forty-two patients were included, with a median age 63 years, whom 19% had Dynamic International Prognostic Scoring System (DIPSS)-plus intermediate-1 risk, 60% intermediate-2 21%...