A5101548898- Extracellular vesicles in disease
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Antibiotic Resistance in Bacteria
- RNA and protein synthesis mechanisms
- Bone and Joint Diseases
- Cancer Research and Treatments
- Retinoids in leukemia and cellular processes
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Gut microbiota and health
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- RNA Research and Splicing
- Antimicrobial Peptides and Activities
- Vibrio bacteria research studies
- Corneal surgery and disorders
- Congenital heart defects research
- Antimicrobial Resistance in Staphylococcus
- Immune cells in cancer
- Invertebrate Immune Response Mechanisms
- Chromosomal and Genetic Variations
Jinzhou Medical University
2013-2024
Shanghai Jiao Tong University
2018-2024
Ministry of Industry and Information Technology
2022-2024
Beihang University
2022-2024
Chengdu University of Traditional Chinese Medicine
2024
Sichuan University
2024
West China Hospital of Sichuan University
2024
Ruijin Hospital
2024
Jiangxi Maternal and Child Health Hospital
2023
Affiliated Hospital of Jining Medical University
2023
Alzheimer's Disease (AD), a progressive neurodegenerative disorder, is marked by cognitive deterioration and heightened neuroinflammation. The influence of Insulin-like Growth Factor 1 Receptor (IGF1R) its post-translational modifications, especially sumoylation, crucial in understanding the progression AD exploring novel therapeutic avenues. This study investigates impact exercise on sumoylation IGF1R role ameliorating symptoms APP/PS1 mice, with specific focus neuroinflammation innovative...
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Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) may modulate the M1/M2 polarization of macrophages during osteoarthritis (OA). However, underlying mechanisms BMSC-Exos in this process still need to be elucidated. In study, we explored role
Abstract Background Infections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China. For this reason, our study comprehensively revealed the resistance mechanisms collected Chinese tertiary care hospital from 2011 2022. Methods Enterococcal were screened verified after retrospective analysis microbial data. Subsequently, 65 (61 Enterococcus faecalis 4 faecium ,...
Objective: To analyze the epidemiological characteristics of drug resistance genes carbapenemase-producing Escherichia coli (CPECO) in Henan Province Hospital Traditional Chinese Medicine from 2021 to 2023, providing data support and theoretical basis for controlling nosocomial infections CPECO. Methods: Using a cross-sectional study, 30 carbapenem-resistant (CRECO) strains confirmed by VITEK-2 Compact identification sensitivity test Clinical Microbiology Laboratory 2023 were tested, using...
Breast cancer is one of the most types common malignant tumor in women. REC8 a known suppressor several cancer; however, role breast remains unknown. The purpose present study was to investigate effects and underlying mechanism on proliferation, migration invasion cells. expression normal cells detected by reverse transcription‑quantitative PCR western blotting. Stable REC8‑overexpressing were constructed modify REC8. cell division cycle 20 (CDC20) altered using CDC20 inhibitor apcin. Cell...
Abstract Background Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) are considered as candidates for osteoporosis (OP) therapy. Estrogen is critical in the maintenance of homeostasis. However, role estrogen and/or its receptor BMSC-Exos treatment OP, well methods regulation during this process remain unclear. Methods BMSCs were cultured and characterized. Ultracentrifugation was performed to collect BMSC-Exos. Transmission electron microscopy, nanoparticle tracking...
Hypoxia-inducible factor 1α (HIF1α) plays stimulatory roles in revascularization the ischemic area of cerebral ischemia. However, hydroxylation proline at 564 and asparagine 803 HIF1α coding sequence facilitated degradation inhibited transcription activity promoter under normoxic conditions confined pro-angiogenic efficacy HIF1α. In present study, mutant containing P564A N803A was constructed by site‑directed mutagenesis. Rat bone marrow mesenchymal stem cells (BMSCs) were infected with...
The massive quantities of bacterial genomic data being generated have facilitated in-depth analyses bacteria for pan-genomic studies. However, the pan-genome compositions one species differed significantly between different studies, so we used Staphylococcus aureus as a model organism to explore influences driving composition. We selected series diverse strains analysis composition S. at level and actual contribution influencing factors (sequence type [ST], source isolation, country date...
Hepatocellular carcinoma (HCC), a worldwide leading cause of morbidity and mortality, is the most frequent primary liver tumor. Most HCC patients are diagnosed with advanced cancer, resulting in very low 5-year survival rate. Thus, there an urgent need for development targeted therapies. In this study, we aimed to investigate effect mechanism miR-20a/EZH1 axis on proliferation metastasis inhibitory EZH1/EZH2 inhibitor UNC1999 HCC.The expression miR-20a human tissues cell lines was detected...
We conducted a randomized, open-label, controlled, multicenter study to compare sulbactam/cefoperazone with cefotaxime in terms of efficacy and safety for the treatment hospitalized patients moderate-to-severe bacterial infections. More than two-thirds pathogens recovered from these produced β-lactamase. Two hundred-seven (88.1%) 235 enrolled completed were included evaluations. One hundred-three received (2–4 g/d) administered evenly divided doses every 12 hours by 30-minute intravenous...
Objective: The study investigated the clinical distribution, antimicrobial resistance and epidemiologic characteristics of hypervirulent Carbapenem-resistant Klebsiella pneumoniae (hv-CRKP) in a hospital Henan Province to provide scientific basis for antibiotic use nosocomial infection prevention control. Methods: A retrospective analysis data from cases was carried out this study. Clinical patients infected with CRKP strain isolated microbiology laboratory Provincial Hospital Traditional...
Body mass index (BMI) is the most commonly used quantitative measure of adiposity. It a kind complex genetic diseases which are caused by multiple susceptibility genes. The first intron fat and obesity-associated (FTO) has been widely discovered to be associated with BMI. Retinitis pigmentosa GTPase regulator-interacting protein-1 like (RPGRIP1L) located in upstream region FTO proved linked obesity through functional tests. We carried out association analysis figure role gene RPGRIP1L A...
Staphylococcus aureus (S. aureus) pneumonia has become an increasingly important public health problem. Recent evidence suggests that epigenetic modifications are critical in the host immune defence against pathogen infection. In this study, we found S. infection induces expression of histone deacetylase 6 (HDAC6) a dose-dependent manner. Furthermore, by using mouse model, showed HDAC6 inhibitor, tubastatin A, demonstrates protective effect pneumonia, decreasing mortality and destruction...
The investigation of enhancer zeste homolog 1 (Ezh1) in the context dengue infection immunity has been limited, necessitating further exploration to elucidate its precise role and underlying mechanisms during infections. To address this gap, we generated Ezh1 knockout mice obtained bone marrow spleen samples from both wild‐type (WT) counterparts. Leveraging RNA sequencing (RNA‐seq) analysis, identified enrichment genes associated with interleukin‐17 (IL‐17) signaling pathway among...
Objective: The context was designed to optimize the diagnostic utility of clinically focused exome sequencing (CFES) and shorten odyssey among pediatric patients suspected monogenic disorders (MDs). Methods: Here, we retrospectively analyzed clinical notes 372 from different areas in Jiangxi province that were referred for a CFES analysis June 2018 March 2022 with symptoms suggestive MDs. In our study, preliminary tests using proband-only as cost-effective first-tier test unidentified MDs,...
Abstract Exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) may modulate the M1/M2 polarization of macrophages during osteoarthritis (OA). However, underlying mechanisms BMSC-Exos in this process still need to be elucidated. In study, effects on after induction lipopolysaccharide (LPS) were determined. The protein expression Akt, PINK1, and Parkin tested. We prepared an OA model by resecting anterior cruciate ligament medial meniscus SD rats. could reduce M1 promote M2...
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogenic bacterium with complex pathogenesis and drug resistance mechanisms. It has high morbidity mortality can cause acute chronic infections in immunocompromised individuals, lung infections, wound bloodstream being the most common. The animal infection model of P. great value for in-depth research on pathogenicity, resistance, therapeutic measures by simulating pathways human bacterial infections. This article firstly...
Abstract Purpose The aim of this study was to determine the genetic cause early onset autosomal dominant hearing loss segregating in five-generation kindred Chinese descent and provide preimplantation testing for them. Methods Clinical examination, pedigree analysis, exome sequencing, minigene-based splicing analysis vivo RNA were carried out on family. Preimplantation (PGT) causative variation chromosome aneuploidis based SNP has been used avoid transmission Results All affected individuals...