A5100756207- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Salivary Gland Disorders and Functions
- Video Surveillance and Tracking Methods
- Cancer-related molecular mechanisms research
- Oral Health Pathology and Treatment
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Periodontal Regeneration and Treatments
- Endodontics and Root Canal Treatments
- Angiogenesis and VEGF in Cancer
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Oral and gingival health research
- Berberine and alkaloids research
- Streptococcal Infections and Treatments
- Caveolin-1 and cellular processes
- Coronary Interventions and Diagnostics
- Dental Radiography and Imaging
- Signaling Pathways in Disease
- Phytochemical Studies and Bioactivities
- Immune cells in cancer
- Infrared Target Detection Methodologies
- Remote-Sensing Image Classification
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Calmette Hospital
2025
University of Health Science
2025
Sichuan University
2011-2024
Wuhan University
2021-2024
Fudan University
2024
Second Hospital of Tianjin Medical University
2024
First Affiliated Hospital of Guangzhou Medical University
2024
State Key Laboratory of Respiratory Disease
2024
The inflammatory responses of monocytes/macrophages and the stimulation lipid uptake into these cells by oxidized low density lipoprotein (oxLDL) are critical to initiation development atherosclerosis. Increasing evidence has demonstrated that many microRNAs play important roles in cell proliferation, apoptosis, differentiation accompany responses. However, whether associated with monocyte/macrophage or oxLDL is not yet known. aim present study investigate their potential role...
BET proteins are a group of epigenetic regulators controlling transcription through reading acetylated histone tails and recruiting complexes. They considered as potential therapeutic targets in many distinct diseases. A novel synthetic bromodomain extraterminal domain (BET) inhibitor, JQ1, was proved to suppress oncogene inflammatory responses. The present study aimed investigate the effects JQ1 on response bone destruction experimental periodontitis. We found that significantly suppressed...
MicroRNAs (miRNAs) and the Wnt signaling pathway play critical roles in regulating bone development homeostasis. Our previous study revealed high expression of miR-335-5p osteoblasts hypertrophic chondrocytes mouse embryos ability to promote osteogenic differentiation by downregulating antagonist Dickkopf-1 (DKK1). The purpose this was investigate effects constitutive overexpression on formation regeneration vivo. To that end, we generated a transgenic line specifically overexpressing...
BackgroundAtherosclerosis (AS) is the basis of diabetic macrovascular complications. The plasma low-density lipoprotein (LDL) particles transcytosis across endothelial cells (ECs) and deposition under endothelium initiation step AS. We previously reported that high glucose inhibits autophagic degradation Caveolin-1 promote LDL ECs, which in turn accelerates atherosclerotic progression. Since Sirt6 a chromatin-associated protein with deacetylation activity, whether it can regulate acetylation...
Hyperspectral videos can provide the spatial, spectral, and motion information of targets, which makes it possible to track camouflaged targets that are similar background. However, hyperspectral object tracking is a challenging task, due huge video data dimension "data hungry" problem for model training. Insufficient training seriously interfere with accuracy generalization models. In this paper, dual deep Siamese network framework (SiamHYPER) proposed learning tracker from pretrained RGB...
Summary 1. Inflammation is central to the pathogenesis of acute coronary syndrome ( ACS ) and associated with adverse clinical outcomes after percutaneous intervention PCI ). Recent in vitro work has demonstrated anti‐inflammatory effect berberine, a primary component traditional C hinese medicine ‘umbellatine’. In present study, we further tested whether berberine had any beneficial effects on patients following . 2.In all, 130 undergoing were recruited study. Sixty‐one treated (300 mg,...
Dysfunction of endothelial progenitor cells (EPCs) contributes to diabetic vascular disease. MicroRNAs (miRs) have emerged as key regulators diverse cellular processes including angiogenesis. We recently reported that miR-126, miR-130a, miR-21, miR-27a, and miR-27b were downregulated in EPCs from type II diabetes mellitus (DM) patients, downregulation miR-126 impairs EPC function. The present study further explored whether dysregulated miR-130a also related dysfunction. cultured peripheral...
Abstract Adiponectin (APN) is an adipocyte-secreted adipokine that exerts well-characterized antidiabetic properties. Patients with type 2 diabetes (T2D) are characterized by reduced APN levels in circulation and impaired stem cell progenitor mobilization from the bone marrow for tissue repair remodeling. In this study, we found regulates recruitment of marrow-derived mesenchymal cells (BMSCs) to participate regeneration. facilitated BMSCs migrating into regenerate regulating stromal...
Macrophage activation plays a central role in neoatherosclerosis and in‐stent restenosis after percutaneous coronary intervention (PCI). Galectin‐3, mainly expressed on macrophages, is an important regulator of inflammation. This study aimed to investigate the effects berberine (BBR) oxidized low‐density lipoprotein (ox‐LDL)‐induced macrophage galectin‐3 expression their underlying mechanisms. THP‐1‐derived macrophages were pretreated with BBR prior stimulation ox‐LDL. Galectin‐3 was...
To elucidate the mechanism whereby advanced glycation end products (AGEs) accelerate atherosclerosis (AS) and to explore novel therapeutic strategies for atherosclerotic cardiovascular disease.The effect of AGEs on low-density lipoprotein (LDL) transcytosis across endothelial cells (ECs) was assessed using an in vitro model LDL transcytosis. We observed that activated receptor (RAGE) surface ECs consequently upregulated Caveolin-1, which turn increased caveolae-mediated accelerated AS...
DICER is the central enzyme that cleaves precursor microRNAs (miRNAs) into 21-25 nucleotide duplex in cell lineage differentiation, identity, and survival. In current study, we characterized specific bone metabolism genes corresponding miRNAs found Runt-related transcription factor 2 (Runx2) expressions increased simultaneously during osteogenic differentiation. Luciferase assay showed Runx2 significantly expression levels of luciferase promoter reporter. Our analysis also revealed weaker...
Hyperspectal target tracking is aimed at taking advantage of the spectral and spatial information in tracking. However, due to limited training samples, existing hyperspectral trackers cannot exploit semantic image. In this paper, order solve problem, we propose an anchor-free Siamese network for video (HA-Net). A classification branch introduced increase network's ability identify objects. This exploits all bands end-to-end training, obtain more discriminative features. By fusing response...
ABSTRACT Despite high levels of global concern, little is known about the epidemiology Clostridioides ( Clostridium ) difficile infection (CDI) in Cambodia. This study aimed to identify prevalence and risk factors for CDI, molecular types C. hospitalized adults at Calmette Hospital, Phnom Penh, Stool samples were collected from 263 between June September 2022 tested using direct enrichment cultures. PCR toxin genes tcdA, tcdB, cdtA , cdtB, amplification 16s–23s rRNA intergenic spacer region...
Objective: To investigate the levels of insulin-like growth factor-1 (IGF-1) and receptor (IGF-1R) in serum placenta patients with preeclampsia (PE), establish their correlations, evaluate diagnostic potential. Methods: 22 PE normal pregnant women who underwent cesarean section deliveries at First Affiliated Hospital Guangxi Medical University between December 2021 2022 were included observation group control group. Enzyme-linked immunosorbent assay (ELISA) was utilized to measure IGF-1...
Periodontitis seriously affects people's daily health, and the development of a non-antibiotic bio-adhesive with antimicrobial periodontitis regeneration for periodontal pockets will effectively promote treatment periodontitis. In this study, we constructed hybrid hydrogel (GelMA-BC-PL) by introducing aldehyde bacterial cellulose (BC) short nanofibers into photosensitive (GelMA), which binds to tissues play an adhesive role through Schiff base reaction, further ε-polylysine (PL), could...
Background and Objective: Porphyromonas gingivalis fimbriae play a key role in colonization of the oral cavity. The fimA gene, which encodes fimbrillin ( FimA ), can be classified into six types (I–V Ib) according to nucleotide sequence. In present study, we investigated relationship between prevalence P. ‐specific genotypes periodontal health status Chinese adults. Material Methods: One‐hundred fifteen patients with chronic periodontitis 136 periodontally healthy adults were selected....
Endothelial progenitor cells (EPCs) play an important role in tissue repair after ischemic heart disease. In particular, the recovery of endothelial function is reliant on ability and rate EPCs differentiate into mature cells. The present study evaluated effect microRNA 107 (miR-107) mechanism differentiation. were isolated from rats' bone marrow miR-107 expression hypoxic normoxic conditions measured by real-time qualitative PCR. CD31 was analyzed flow cytometry eNOS examined PCR western...
Dysfunction of endothelial progenitor cells (EPC) contribute to diabetic vascular disease. MicroRNAs (miRNAs) are key regulators diverse cellular processes, including angiogenesis. We recently reported that downregulated miR-130a in patients with Type 2 diabetes mellitus (DM) results EPC dysfunction, increased apoptosis, likely via its target runt-related transcription factor 3 (Runx3). However, whether affects the autophagy is unknown. The aim present study was explore effects on and cell...
Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in patients causes EPC dysfunction. The study was designed investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate expression whether mediates the effects HG AGEs on EPCs.We first tested (5.5-50 mM) at 50-200 mg/l proliferation selected 50 mM for further experiments. EPCs were stimulated with AGEs, measured by real-time PCR. Reactive...
Our previous in vitro and clinical work has demonstrated anti-inflammatory effects of berberine (BBR), but the application BBR is limited by its poor bioavailability. Derivatives have been suggested to enhanced bioavailability compared BBR. In this study, we tested whether derivatives, with BBR, had superior beneficial on atherosclerotic plaques apoE−/− mice, defined possible molecular mechanisms underlying such effects. Macrophages were pretreated dihydroberberine (dhBBR)...
Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis male knockout diet-induced obesity mice, a model type 2 diabetes, aimed at evaluating therapeutic potential adiponectin. We found systemic infusion reduced alveolar bone loss, osteoclast activity infiltration inflammatory cells both mouse models. Furthermore, treatment decreased...
Abstract Background Endothelial progenitor cells (EPCs) contribute to reendothelialization and neovascularization protect against vascular injury ischemia of various organs. We have previously shown downregulation microRNA (miR)-126 in EPCs from diabetic patients, which contributes dysfunction including impaired migratory ability. The aims the present study were examine (1) vitro effects miR-126 on homing stemness late outgrowth (LOCs), along with relevant signaling pathways, (2) vivo...