A5039100506- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nerve injury and regeneration
- Ferroptosis and cancer prognosis
- Graphene and Nanomaterials Applications
- Autophagy in Disease and Therapy
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Online and Blended Learning
- Circular RNAs in diseases
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Sexual Differentiation and Disorders
- Orthopedic Infections and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Nitric Oxide and Endothelin Effects
- Ubiquitin and proteasome pathways
- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Mitochondrial Function and Pathology
Zhangjiakou Academy of Agricultural Sciences
2025
Air Force Medical University
2015-2024
Nanjing University
2004-2024
Nanjing Medical University
2002-2024
Nanjing General Hospital of Nanjing Military Command
2017-2024
The University of Texas Health Science Center at San Antonio
2007-2024
Nanjing University of Chinese Medicine
2024
Chongqing University of Posts and Telecommunications
2024
Wuhan Polytechnic University
2024
Shanghai Stomatological Hospital
2024
Polyploidization has provided much genetic variation for plant adaptive evolution, but the mechanisms by which molecular evolution of polyploid genomes establishes architecture underlying species differentiation are unclear. Brassica is an ideal model to increase knowledge evolution. Here we describe a draft genome sequence oleracea, comparing it with that its sister B. rapa reveal numerous chromosome rearrangements and asymmetrical gene loss in duplicated genomic blocks, amplification...
Mutations in parkin , an E3 ubiquitin ligase, are the most common cause of autosomal-recessive Parkinson's disease (PD). Here, we show that stress-signaling non-receptor tyrosine kinase c-Abl links to sporadic forms PD via phosphorylation. Under oxidative and dopaminergic stress, was activated cultured neuronal cells striatum adult C57BL/6 mice. Activated found patients. Concomitantly, tyrosine-phosphorylated, causing loss its ligase cytoprotective activities, accumulation substrates, AIMP2...
Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular endothelium (VE). The most principle mechanism might be excess reactive oxygen species (ROS) generation. Nevertheless, characteristics of ROS generation, downstream mechanisms, target organelles in Dox-induced have yet to elucidated. Methods Results: In order explore related problems, VE injury models were established mice human umbilical vein endothelial cells (HUVECs) by endotheliotoxicity. Results showed...
Glial cell line-derived neurotrophic factor (GDNF) has emerged as the most potent neuroprotective agent tested in experimental models for treatment of Parkinson's disease (PD). However, its use is hindered by difficulties delivery to brain due presence blood-brain barrier (BBB). In order circumvent this problem, we took advantage fact that bone marrow stem cell-derived macrophages are able pass BBB and home sites neuronal degeneration. Here, report development a method GDNF genetically...
Task-Based Learning (TBL) is a student-centered, teacher-guided and task-performed teaching approach. This study was aimed to investigate the effects of task-based learning in chemistry experiment on promoting high school students' critical thinking skills Xi'an, China. To achieve aims, pre-test post-test experimental design with an group control employed. Students were taught TBL, while students lecturing methods. Five chemical experiments selected, 119 aged at 17 - 19 voluntarily...
Poly(β-L-malic acid) (PMLA), a natural aliphatic polyester, has been proven to be promising carrier for anti-cancer drugs.In spite of excellent bio-compatibility, the application PMLA as drug cancer therapy is limited by its low cellular uptake efficiency.The strong negative charge impedes cells because electrostatic repulsion.In this study, dual pH-sensitive charge-reversal PMLA-based nanocomplex (PMLA-PEI-DOX-TAT@PEG-DMMA) was developed effective tumor-targeted delivery, enhanced uptake,...
Abstract Cancer is one of the most deadly diseases in world. In recent years, nanotechnology, as a unique technology, has been comprehensively applied therapy cancer through diagnosis, imaging and theranostics. Additionally, with emergence advanced biomaterials which are capable being biomedical, research nanotechnology made significant progress. Particularly, nanomaterials dimensions below several hundred nanometers intensively studied among these biomaterials. past decades, number organic...
Few researchers examined different red light amounts added in white light-emitting diodes (LEDs) with varied daily integrals (DLIs) for hydroponic lettuce ( Lactuca sativa L.). In this study, effects of DLI and LED quality (LQ) on growth, nutritional quality, energy use efficiency were investigated a plant factory artificial lighting (PFAL). Hydroponic plants (cv. Ziwei) grown 20 days under combinations five levels DLIs at 5.04, 7.56, 10.08, 12.60, 15.12 mol·m −2 ·d −1 four LQs: two kinds...
Kaempferol (Kae), a flavonoid, has been found in fruits and other vegetables, possesses many biological activities. 14-3-3 protein exerts protection on various types of injured tissues cells. Doxorubicin (Dox) causes excessive reactive oxygen species (ROS) generation, which induces endotheliotoxicity cardiotoxicity. We hypothesized that Kae could protect vascular endothelium by regulating 14-3-3γ or related pathways against Dox toxicity. HUVECs were established Dox-toxic injury models. Kae's...
Cyclic stability of elastocaloric effect is the key factor that restricts cooling application Ni–Mn–Sn alloys fabricated by conventional melting technique. Element doping an effective way to enhance performance materials. In this work, Tb substitution for Ni on martensitic transformation (MT) temperature, microstructure, mechanical properties and cyclic in Ni43.5–xTbxMn45.5Sn11 (x = 0, 0.6, 1.2 1.8) magnetic shape memory has been investigated. MT temperatures increase with increasing x from...
Cardiac hypertrophy is characterized by increased myofibrillogenesis. Angiotensin II (Ang-II) an essential mediator of the pressure overload-induced cardiac in part through RhoA/ROCK (small GTPase/Rho-associated coiled-coil containing protein kinase) pathway. FHOD3 (formin homology 2 domain 3), a cardiac-restricted member diaphanous-related formins, crucial regulating myofibrillogenesis cardiomyocytes. maintains inactive autoinhibition intramolecular interaction between its C- and N-terminal...
Surface functionalization by small interfering RNA (siRNA) is a novel strategy for improved implant osseointegration. A gene delivery system with safety and high transfection activity crucial factor an siRNA-functionalized to exert its biological function. To this end, polyethylene glycol (PEG) polyethylenimine (PEI) dual-functionalized graphene oxide (GO; nGO–PEG–PEI) may present promising siRNA vector. In study, nanosized nGO–PEG–PEI was prepared optimized delivery. Titania nanotubes (NTs)...
Our previous in vitro and clinical work has demonstrated anti-inflammatory effects of berberine (BBR), but the application BBR is limited by its poor bioavailability. Derivatives have been suggested to enhanced bioavailability compared BBR. In this study, we tested whether derivatives, with BBR, had superior beneficial on atherosclerotic plaques apoE−/− mice, defined possible molecular mechanisms underlying such effects. Macrophages were pretreated dihydroberberine (dhBBR)...