A5079116519- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Retinal Diseases and Treatments
- Complementary and Alternative Medicine Studies
- Health, psychology, and well-being
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Antibiotic Resistance in Bacteria
- Angiogenesis and VEGF in Cancer
- Endoplasmic Reticulum Stress and Disease
- Lipid metabolism and disorders
- School Health and Nursing Education
- Autoimmune Neurological Disorders and Treatments
- Craniofacial Disorders and Treatments
- Electroconvulsive Therapy Studies
- Food Allergy and Anaphylaxis Research
- Cellular transport and secretion
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Health and Medical Research Impacts
- Health and Medical Studies
- Reconstructive Facial Surgery Techniques
- Cardiovascular Issues in Pregnancy
- Diversity and Career in Medicine
University of Utah
2016-2023
University of Utah Health Care
2018-2019
Institute of Molecular Medicine
2017
The devastating sequelae of diabetes mellitus include microvascular permeability, which results in retinopathy. Despite clinical and scientific advances, there remains a need for new approaches to treat Here, we have presented possible treatment strategy, whereby targeting the small GTPase ARF6 alters VEGFR2 trafficking reverses signs pathology 4 animal models that represent features diabetic retinopathy fifth model ocular pathological angiogenesis. Specifically, determined same signaling...
The activation of the small GTPase ARF6 has been implicated in promoting several pathological processes related to vascular instability and tumor formation, growth, metastasis. also plays a vital role during embryonic development. Recent studies have suggested that carries out these disparate functions primarily by controlling protein trafficking within cell. helps direct proteins intracellular or extracellular locations where they function normal cellular responses development later life....
Breakdown of the blood-central nervous system barrier (BCNSB) is a hallmark many neuroinflammatory disorders, such as multiple sclerosis (MS). Using mouse model MS, experimental autoimmune encephalomyelitis (EAE), we show that endothelial-to-mesenchymal transition (EndoMT) occurs in CNS before onset clinical symptoms and plays major role breakdown BCNSB function. EndoMT can be induced by an IL-1β-stimulated signaling pathway which activation small GTPase ADP ribosylation factor 6 (ARF6)...
The rise in multidrug-resistant (MDR) organisms portends a serious global threat to the health care system with nearly untreatable infectious diseases, including pneumonia and its often fatal sequelae, acute respiratory distress syndrome (ARDS) sepsis. Gram-negative bacteria (GNB),
Background Pain is an underappreciated symptom of atopic dermatitis that can affect the health-related quality life (HRQL) patients. Objective The aim this study to understand effect pain on patients with and their family members recognize how affects HRQL. Methods We conducted focus groups interviews members. Researchers independently coded transcripts reached a consensus major themes. Results A total 33 adult participants, consisting 21 (median age 47 years, range 22-77) 12 50, 22-72),...
Takotsubo cardiomyopathy (TCM) is a rare stress-induced condition that appears rarely in suspected acute myocardial infarction cases. It causes unexplained left ventricular failure, but most cases are reversible with supportive treatment. In this report, we present the case of 70-year-old female who developed hypotension after laparoscopic Toupet fundoplication on postoperative day one, requiring care surgical intensive unit. Following consultation cardiology service and further imaging...
Abstract Catatonia can be described structurally as a motor dysregulation syndrome with concomitant behavioral component. However, despite its initial recognition nearly 150 years ago, the exact pathophysiological causes underlying this are still somewhat unknown and potentially variable. This report reviews case of patient multiple catatonic episodes precipitated by use an immunomodulator medication, in doing so suggests possible mechanism speaking to immune system's role etiology some...
Patients with psoriasis commonly report experiencing severe sensory symptoms, and the burden of these symptoms can extend beyond unpleasant experiences to impair patients' health-related quality life (HRQL). However, symptom pain its consequences are still poorly understood in patients.
The emergence of precision medicine and population health reveals a potential divergence perspective among experts in these fields. Personalizing diagnostic therapeutic interventions to address the needs individual patients raises specter increased costs without addressing need for that enhance broader population. This symposium brought together medicine, science, law ethics discuss debate issues.
Large cohort studies and more recently electronic medical records (EMR) are being used to collect massive amounts of genetic information. Implementation artificial intelligence has become increasingly necessary interpret this data with the goal augmenting patient care. While it is impossible predict what future holds, policy makers challenged create guiding principles responsibly roll out these new technologies. On March 22, 2019, University Utah hosted its fourth annual Precision Medicine...
ABSTRACT The rise in multidrug resistant (MDR) organisms portends a serious global threat to the healthcare system with nearly untreatable infectious diseases, including pneumonia and its often fatal sequelae, acute respiratory distress syndrome (ARDS) sepsis. Gram-negative bacteria (GNB) Acinetobacter baumannii, Pseudomonas aeruginosa , carbapenemase-producing Klebsiella pneumoniae (CPKP), are among World Health Organization National Institutes of Health’s high priority MDR pathogens for...
The management of blast and burn injuries to the facial soft tissue craniomaxillofacial skeleton has been a challenge since inception reconstructive plastic surgery. These continue present complex challenges today. While there have advancements in free transfer vascularized composite allotransplantation, prosthetics used successfully antiquity until day. Prosthetics may achieve acceptable coverage without surgery or as an adjunct Here, we report case devastating injury face that managed with...
Psoriasis is a chronic skin condition with significant effects on quality of life, including impacts emotional health. However, these experiences are not always addressed in clinic visits, despite their potential for daily life. This study part larger project the psoriasis The current information was analyzed separately because amount mentioned by participants so that it warranted separate analysis to thoroughly assess experiences.