A5084279534- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Heart Failure Treatment and Management
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Hormonal Regulation and Hypertension
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Sodium Intake and Health
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Statistical Methods in Clinical Trials
- Genetic Associations and Epidemiology
- Cardiovascular Syncope and Autonomic Disorders
- Pharmacogenetics and Drug Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Health and Mental Health
- Cardiac pacing and defibrillation studies
- Hemodynamic Monitoring and Therapy
- Dementia and Cognitive Impairment Research
- Pharmaceutical Economics and Policy
- Health, Environment, Cognitive Aging
- Pharmaceutical studies and practices
- Cardiac Imaging and Diagnostics
University of Utah
2016-2025
Intermountain Healthcare
2022-2025
George E. Wahlen Department of VA Medical Center
2017-2025
VA Salt Lake City Healthcare System
2015-2024
University of Alabama at Birmingham
2016-2020
University of Mississippi Medical Center
2017-2020
Jackson Memorial Hospital
2017-2020
MedStar Washington Hospital Center
2020
University of Utah Health Care
2018-2019
Bishkek Academy of Finance and Economics
2015-2019
Little is known regarding the association between level of blood pressure (BP) in young adulthood and cardiovascular disease (CVD) events by middle age.To assess whether adults who developed hypertension, defined 2017 American College Cardiology (ACC)/American Heart Association (AHA) BP guideline, before age 40 years have higher risk for CVD compared with those maintained normal BP.Analyses were conducted prospective cohort Coronary Artery Risk Development Young Adults (CARDIA) study,...
The burden of atherosclerotic cardiovascular disease (ASCVD) in the US is higher among Black and Hispanic vs White adults. Inclusion race guidance for statin indication may lead to decreased disparities use.
To compare healthcare resource utilization (HRU) and clinical decision-making for elderly patients based on cytochrome P450 (CYP) pharmacogenetic testing the use of a comprehensive medication management decision support tool (CDST), to cohort similar non-tested patients.An observational study compared prospective ≥65 years subjected propensity score (PS) matched historical untested in claims database. Patients had prescribed or dose change at least one 61 oral drugs combinations ≥3...
Background: SPRINT (Systolic Blood Pressure Intervention Trial) demonstrated a 27% reduction in all-cause mortality with systolic blood pressure (SBP) goal of <120 versus <140 mm Hg among US adults at high cardiovascular disease risk but without diabetes mellitus, stroke, or heart failure. To quantify the potential benefits and risks intensive implementation, we estimated deaths prevented excess serious adverse events incurred if SBP treatment were implemented all eligible adults....
Blood pressure (BP) control rates among US adults taking antihypertensive medication have not increased over the past decade. Many require 2 or more classes of to achieve guideline-recommended BP goals, but proportion monotherapy, versus combination therapy, has been quantified using contemporary data. We analyzed data from 2005 2008, 2009 2012, and 2013 2016 National Health Nutrition Examination Surveys determine trends in monotherapy combinations age ≥20 years with hypertension (n=7837)....
Recent clinical trial data cast doubt on the utility of genotype-guided warfarin dosing, specifically showing worse dosing with a pharmacogenetic versus algorithm in African Americans. However, many genotypes important Americans were not accounted for. We aimed to determine whether omission CYP2C9*5, CYP2C9*6, CYP2C9*8, CYP2C9*11 alleles and rs12777823 G > A genotype affects performance algorithms Americans.In cohort 274 warfarin-treated Americans, we examined association between dose...
Background Intensive systolic blood pressure ( SBP ) lowering significantly reduced cardiovascular disease CVD events in SPRINT (Systolic Blood Pressure Intervention Trial) but not ACCORD BP (Action to Control Cardiovascular Risk Diabetes Pressure). Methods and Results tested the effects of intensive (<120 mm Hg) versus standard (<140 goals on all‐cause mortality. Using 2×2 factorial design, same intervention addition an glycemia intervention. We compared composite end point mortality...
Low antihypertensive medication adherence is common. During recent years, the impact of low on increased morbidity and healthcare costs has become more recognized, leading to interventions aimed at improving adherence. We analyzed a 5% sample Medicare beneficiaries initiating between 2007 2012 assess whether reductions occurred in discontinuation Discontinuation was defined as having no days supply for final 90 365 after initiation. proportion covered <80% during initiation among who did not...
The Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive blood pressure control reduced cardiovascular morbidity and mortality. However, the legacy effect of treatment is unknown.To evaluate long-term effects randomization to with incidence all-cause mortality approximately 4.5 years after trial ended.In this secondary analysis a multicenter randomized clinical trial, began on November 8, 2010, intervention ended August 20, 2015, close-out visits occurred through July...
<h3>Importance</h3> Antihypertensive treatments benefit cerebrovascular health and cognitive function in patients with hypertension, but it is uncertain whether an intensive blood pressure target leads to potentially harmful cerebral hypoperfusion. <h3>Objective</h3> To investigate the association of systolic (SBP) control vs standard whole-brain flow (CBF). <h3>Design, Setting, Participants</h3> This substudy Systolic Blood Pressure Intervention Trial (SPRINT) randomized clinical trial...
Data from the US National Health and Nutrition Examination Survey are freely available can be analyzed to produce hypertension statistics for noninstitutionalized population. The analysis of these data requires statistical programming expertise knowledge methodology.
Study Objective To determine the procedural feasibility of a pharmacist‐led interdisciplinary service for providing genotype‐guided warfarin dosing hospitalized patients newly starting warfarin. Design Prospective observational study. Setting A 438‐bed tertiary care hospital affiliated with large academic institution. Patients Eighty who started therapy and were managed by implemented pharmacogenetics service. Intervention All received routine genotyping clinical consultation. Measurements...
OBJECTIVE To determine whether the effects of intensive (&lt;120 mmHg) compared with standard (&lt;140 systolic blood pressure (SBP) treatment are different among those prediabetes versus fasting normoglycemia at baseline in Systolic Blood Pressure Intervention Trial (SPRINT). RESEARCH DESIGN AND METHODS This was a post hoc analysis SPRINT. SPRINT participants were categorized by status, defined as serum glucose ≥100 mg/dL (fasting &lt;100 mg/dL). The primary outcome composite...
Determining the appropriate dosage of warfarin is an important yet challenging task. Several prediction models have been proposed to estimate a therapeutic dose for patients. The are either clinical which contain and demographic variables or pharmacogenetic additionally genetic variables. In this paper, new methodology dosing proposed. patients initially classified into two classes. first class contains who require doses >30 mg/wk second ≤30 mg/wk. This phase performed using relevance vector...
To evaluate the effect of intensive systolic blood pressure (SBP) control in older adults with hypertension, considering cognitive and physical function.Secondary analysis.Systolic Blood Pressure Intervention Trial (SPRINT) PARTICIPANTS: Adults 80 years or older.Participants hypertension but without diabetes (N = 1167) were randomized to an SBP target below 120 mm Hg (intensive treatment) vs a 140 (standard treatment).We measured incidence cardiovascular disease (CVD), mortality, changes...
The COVID-19 pandemic is a public health crisis, having killed more than 514 000 US adults as of March 2, 2021. mitigation strategies have unintended consequences on managing chronic conditions such hypertension, leading cause cardiovascular disease and disparities in the United States. During first wave States, combination observed racial/ethnic inequities deaths social unrest reinvigorated national conversation about systemic racism care society. 4th Annual University Utah Translational...
<h3>Importance</h3> Use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors, compared with those do not these has been associated a lower risk dementia. However, this association cognitive outcomes in hypertension trials, blood pressure levels the range current guidelines, evaluated. <h3>Objective</h3> To examine between use exclusively medication regimens vs inhibit receptors on mild impairment (MCI) or <h3>Design, Setting, Participants</h3> This cohort...