A5031963424- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Lipoproteins and Cardiovascular Health
- Cardiac, Anesthesia and Surgical Outcomes
- Hormonal Regulation and Hypertension
- Pharmaceutical Economics and Policy
- Cardiovascular Health and Risk Factors
- Hemodynamic Monitoring and Therapy
- Diabetes Treatment and Management
- Pharmaceutical industry and healthcare
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dementia and Cognitive Impairment Research
- Cardiovascular Syncope and Autonomic Disorders
- Long-Term Effects of COVID-19
- Heart Rate Variability and Autonomic Control
- Biosimilars and Bioanalytical Methods
- Obesity, Physical Activity, Diet
- Venous Thromboembolism Diagnosis and Management
- Pharmacology and Obesity Treatment
- Acute Myocardial Infarction Research
- Diabetes Management and Research
- Renin-Angiotensin System Studies
- Sodium Intake and Health
University of Utah
2020-2025
Intermountain Healthcare
2022-2025
University of Colorado Anschutz Medical Campus
2019-2025
VA Salt Lake City Healthcare System
2024
Kaiser Permanente
2018-2020
University of Montana
2018-2020
American College of Clinical Pharmacy
2020
University of Alabama at Birmingham
2020
University of Colorado Denver
2019
The burden of atherosclerotic cardiovascular disease (ASCVD) in the US is higher among Black and Hispanic vs White adults. Inclusion race guidance for statin indication may lead to decreased disparities use.
Blood pressure (BP) control rates among US adults taking antihypertensive medication have not increased over the past decade. Many require 2 or more classes of to achieve guideline-recommended BP goals, but proportion monotherapy, versus combination therapy, has been quantified using contemporary data. We analyzed data from 2005 2008, 2009 2012, and 2013 2016 National Health Nutrition Examination Surveys determine trends in monotherapy combinations age ≥20 years with hypertension (n=7837)....
Data from the US National Health and Nutrition Examination Survey are freely available can be analyzed to produce hypertension statistics for noninstitutionalized population. The analysis of these data requires statistical programming expertise knowledge methodology.
<h3>Importance</h3> Use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors, compared with those do not these has been associated a lower risk dementia. However, this association cognitive outcomes in hypertension trials, blood pressure levels the range current guidelines, evaluated. <h3>Objective</h3> To examine between use exclusively medication regimens vs inhibit receptors on mild impairment (MCI) or <h3>Design, Setting, Participants</h3> This cohort...
Importance Intensive vs standard treatment to lower systolic blood pressure (SBP) reduces risk of mild cognitive impairment (MCI) or dementia; however, the magnitude benefit likely varies among patients. Objective To estimate intensive BP treatment. Design, Setting, and Participants In this ad hoc secondary analysis Systolic Blood Pressure Intervention Trial (SPRINT), 9361 randomized clinical trial participants 50 years older with high cardiovascular but without a history diabetes, stroke,...
The authors declare no conflicts of interest.
Background Fixed-dose combination (FDC) antihypertensive products improve blood pressure control and adherence among patients with hypertension. It is unknown to what degree commercially available FDC meet the current hypertension management prescription patterns in United States. Methods Results This cross-sectional analysis of National Health Nutrition Examination Surveys 2015 March 2020 included participants taking ≥2 medications (N=2451). After constructing each participant's regimen...
Despite reducing cardiovascular disease (CVD) events and death in SPRINT (Systolic Blood Pressure Intervention Trial), intensive systolic blood pressure goals have not been adopted the United States. This study aimed to simulate potential long-term impact of 4 hypertension management strategies SPRINT-eligible US adults.
Abstract Aims To compare the risk of all‐cause death and cardiovascular events in new users insulin glargine, glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) sodium‐glucose cotransporter‐2 inhibitors (SGLT2i), particularly subgroups defined by baseline haemoglobin A1C (HbA1C), body mass index (BMI) estimated glomerular filtration rate (eGFR). Materials Methods We conducted an active comparator, user design study a national cohort 161 405 veterans with type 2 diabetes (T2D) on metformin...
Abstract Background Whether the differing mechanistic effects between angiotensin-2 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) on renin-angiotensin system translate to differential clinical cognitive outcomes is unclear. Methods We employed an active comparator, new-user cohort study emulate a target trial evaluating per-protocol effect of initiating continuously adhering ARB vs. ACEI adjudicated amnestic mild impairment (MCI) probable dementia (PD) in...
What would you do if someone approached to sign a publishing form on your partner's behalf within mere weeks of their death? After my trusted, brilliant coworker died, I grappled daily between grieving her loss and driving productivity assigned projects. Because, after all, the world keeps spinning, research progresses, manuscripts have be published. In attempting honor memory through post-mortem authorship publications, was faced with unique quandary how procure signature legal forms, which...
Background: Hypertension is a leading cause of cardiovascular disease and disproportionately affects African American (AA) adults, contributing significantly to morbidity mortality in this population. Apparent Treatment Resistant hypertension (aTRH), where blood pressure (BP) remains uncontrolled despite the use multiple antihypertensive medications, particularly prevalent among AA adults. Sodium intake associated with BP levels, yet relationship between urinary sodium (a measure dietary...
Introduction: The prevalence of blood pressure (BP) control <140/90 mmHg in the Veterans Health Administration (VHA) early 2000s was high (>75%). However, 2017 American College Cardiology (ACC)/American Heart Association (AHA) BP guideline and COVID-19 pandemic may have affected pre-and-post treatment BP. Research Question: Were there changes systolic (SBP, mmHg) relative to guidelines pandemic? Methods: Our retrospective study included initiating antihypertensive medication VHA...
<h3>Importance</h3> The Reduction of Cardiovascular Events With Icosapent Ethyl–Intervention Trial (REDUCE-IT) demonstrated the efficacy icosapent ethyl (IPE) for high-risk patients with hypertriglyceridemia and known cardiovascular disease or diabetes at least 1 other risk factor who were treated statins. <h3>Objective</h3> To estimate cost-effectiveness IPE compared standard care despite statin treatment. <h3>Design, Setting, Participants</h3> An in-trial analysis was performed using...
Understanding how statins, ezetimibe, and PCSK9i (proprotein convertase subtilisin/kexin type 9 serine protease inhibitors) are prescribed after a myocardial infarction (MI) or elective coronary revascularization may improve lipid-lowering therapy (LLT) intensification reduce recurrent atherosclerotic cardiovascular disease events. We described the use of LLT among US veterans who had MI between July 24, 2015, December 9, 2019, within 12 months hospital discharge.LLT was defined as...
Therapeutic inertia may contribute to racial and ethnic differences in blood pressure (BP) control.To determine the association between race ethnicity therapeutic Systolic Blood Pressure Intervention Trial (SPRINT).This cross-sectional study was a secondary analysis of data from SPRINT, randomized clinical trial comparing intensive (<120 mm Hg) vs standard (<140 systolic BP treatment goals. Participants were enrolled November 8, 2010, March 15, 2013, with median follow-up 3.26 years....
Despite evidence supporting the cardiovascular and cognitive benefits of intensive blood pressure management, older adults have lowest rates control. We determined association between age therapeutic inertia (TI) in SPRINT (Systolic Blood Pressure Intervention Trial), whether frailty, function, or gait speed moderate mediate these associations.
Background Canadian Cardiovascular Society (CCS) angina severity classification is associated with mortality, myocardial infarction, and coronary revascularization in clinical trial registry data. The objective of this study was to determine associations between CCS class all-cause mortality healthcare utilization, using natural language processing extract classifications from notes. Methods Results In retrospective cohort veterans the United States stable January 1, 2006, December 31, 2013,...
Few published studies exist to describe the off-label use of multiple-dose fosfomycin for outpatient treatment complicated urinary tract infections (UTI). The purpose this study was characterize patients, infections, drug susceptibilities, and outcomes episodes UTI treatment.This retrospective evaluated patients who received an prescription between July 1999 June 2018. Multiple-dose prescriptions dispensed prophylaxis were excluded. primary outcome clinical resolution (complete signs...