A5043217726- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Bipolar Disorder and Treatment
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Sedative Agents
- Mental Health Research Topics
- Neurological disorders and treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Tryptophan and brain disorders
- Ultrasound and Hyperthermia Applications
- Receptor Mechanisms and Signaling
- Transcranial Magnetic Stimulation Studies
- Hearing Loss and Rehabilitation
- Attachment and Relationship Dynamics
- Anesthesia and Neurotoxicity Research
- Neuroscience and Music Perception
- Vagus Nerve Stimulation Research
- Ultrasound Imaging and Elastography
- Neuropeptides and Animal Physiology
- Noise Effects and Management
University of Utah
2016-2025
Huntsman Cancer Institute
2021-2024
University of Michigan
2014-2023
Michigan United
2018
Radiation Oncology Associates
1986
High placebo responses have been observed across a wide range of pathologies, severely impacting drug development.To examine neurochemical mechanisms underlying the formation effects in patients with major depressive disorder (MDD).In this study involving 2 lead-in phases followed by an open antidepressant administration, we performed single-blinded 2-week crossover randomized clinical trial identical oral placebos (described as having either active or inactive fast-acting...
Background Recent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features illness. Heterogeneity findings to date may stem from the relative lack data parsing clinical MDD such as phase illness burden multiple episodes. Method Resting-state functional magnetic resonance imaging were collected 17 active 34 remitted patients, 26 healthy controls (HCs) across two sites. Participants medication-free...
Severe forms of depression have been linked to hyperactivity the subcallosal cingulate cortex. The ability stimulate cortex or associated circuits noninvasively and directly would maximize number patients who could receive treatment. To this end, we developed an ultrasound-based device for effective noninvasive modulation deep brain circuits. Here describe application tool individual with treatment-resistant depression.
Abstract Transcranial focused ultrasound provides noninvasive and reversible approaches for precise personalized manipulations of brain circuits, with the potential to transform our understanding function treatments dysfunction. However, effective applications in humans have been limited by human head, which attenuates distorts severely unpredictably. This has led uncertain intensities delivered into brain. Here, we address this lingering barrier using a direct measurement approach that can...
<h3>Context</h3> Despite recent progress in describing the common neural circuitry of emotion and stress processing, bases individual variation are less well understood. Genetic variants that underlie psychiatric disease have proven particularly difficult to elucidate. Functional genetic neuropeptide Y (NPY) was recently identified as a source differences emotion. Low NPY levels been reported major depressive disorder (MDD). <h3>Objective</h3> To determine whether...
We hypothesized that propofol, a unique general anesthetic engages N-methyl-D-aspartate and gamma-aminobutyric acid receptors, has antidepressant properties. This open-label trial was designed to collect preliminary data regarding the feasibility, tolerability, efficacy of deep propofol anesthesia for treatment-resistant depression.Ten participants with moderate-to-severe medication-resistant depression (age 18-45 years otherwise healthy) each received series 10 infusions. Propofol dosed...
Low-intensity focused ultrasound provides the means to noninvasively stimulate or release drugs in specified deep brain targets. However, successful clinical translations require hardware that maximizes acoustic transmission through skull, enables flexible electronic steering, and accurate reproducible targeting while minimizing use of MRI. We have developed a device addresses these practical requirements. The delivers temporal parietal skull windows, which minimize attenuation distortions...
We evaluated the spatial selectivity of auditory cortical neurons in awake cats. Single- and multiunit activity was recorded primary cortex as animals performed a nonspatial discrimination or sat idly. Their heads were unrestrained, head position tracked. Broadband sounds delivered from locations throughout 360 degrees on horizontal plane, source expressed head-centered coordinates. As anesthetized animals, firing rates most units modulated by sound location, responded best to contralateral...
We compared the spatial tuning properties of neurons in two fields [primary auditory cortex (A1) and posterior field (PAF)] cat cortex. Broadband noise bursts 80-ms duration were presented from loudspeakers throughout 360° horizontal plane (azimuth) or 260° vertical median (elevation). Sound levels varied 20 to 40 dB above units' thresholds. recorded neural spike activity simultaneously 16 sites PAF and/or A1 α-chloralose-anesthetized cats. assessed sensitivity by examining dependence count...
Predicting treatment response for major depressive disorder can provide a tremendous benefit our overstretched health care system by reducing number of treatments and time to remission, thereby decreasing morbidity. The present study used neural performance predictors during cognitive control task predict (% change in Hamilton Depression Rating Scale pre- post-treatment). Forty-nine individuals diagnosed with were enrolled intent treat the open-label study; 36 completed treatment, had...
Multiple studies suggest that the risks of depression and suicide increase with increasing altitude residence, but no have assessed whether changing changes these risks. To address this gap, study used data from Intern Health Study, which follows students end medical school through first year residency, recording via 9-item Patient Questionnaire (PHQ-9), anxiety 7-item Generalized Anxiety Disorder (GAD-7), multiple risk factors for symptoms. Data 3764 representing 46 schools 282 residencies...
RECOVER is a randomized sham-controlled trial of vagus nerve stimulation and the largest such conducted with psychiatric neuromodulation intervention. To describe pre-implantation baseline clinical characteristics treatment history patients unipolar, major depressive disorder (MDD), overall as function exposure to interventional treatments (INTs), including electroconvulsive therapy, transcranial magnetic stimulation, esketamine. Medical, psychiatric, records were reviewed by study...
INTRODUCTION: Deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) improves symptoms in ∼66% of treatment-refractory patients. Recent advances surgical neuromodulation have enabled chronic and continuous intracranial monitoring during everyday life. METHODS: Twelve patients with TR-OCD were implanted a DBS generator the ventral capsule/ventral striatum (VC/VS) that can record spectral power within 5 Hz wide band (9 ± 2.5 Hz). We thus obtained chronic, passive recordings this...