A5037801459- Genomic variations and chromosomal abnormalities
- Semiconductor materials and interfaces
- Protease and Inhibitor Mechanisms
- Semiconductor materials and devices
- Bacterial Genetics and Biotechnology
- Genetics and Neurodevelopmental Disorders
- ZnO doping and properties
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Prenatal Screening and Diagnostics
- Genomics and Rare Diseases
- Kawasaki Disease and Coronary Complications
- Copper-based nanomaterials and applications
- Quantum Dots Synthesis And Properties
- Congenital heart defects research
- Coronary Artery Anomalies
- Bladder and Urothelial Cancer Treatments
- Bacterial biofilms and quorum sensing
- Peptidase Inhibition and Analysis
- Genetic Syndromes and Imprinting
- Transition Metal Oxide Nanomaterials
- Connective tissue disorders research
- COVID-19 and healthcare impacts
- RNA modifications and cancer
- Ion-surface interactions and analysis
- Pregnancy and preeclampsia studies
University of Houston
2018-2025
Post Graduate Institute of Medical Education and Research
2015-2025
Manav Rachna International Institute of Research and Studies
2017-2025
Vanderbilt University Medical Center
2020-2025
Lala Lajpat Rai Memorial Medical College
2024
Amherst College
2017-2024
University of Massachusetts Amherst
2015-2024
Vellore Institute of Technology University
2020-2024
Rowan University
2024
Sarala Birla University
2024
Nanomaterials (NMs) have acquired a place of prominence in scientific innovations due to their unique and tunable physicochemical properties. This versatility enables them be employed multitude applications. Nano/ nanobiotechnology, consequently, has become very research intensive field over past few years accordingly, there been noticeable increase nano enabled products the market. Downsides this, however started catching everyone's attention recently as overuse these particles from labs...
Abstract Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In original cascade model coagulation, FXI converted FXIa XIIa (FXIIa), component, along with prekallikrein and high-molecular-weight kininogen (HK), kallikrein-kinin system (KKS). More recent coagulation models emphasize thrombin as activator, bypassing need for FXIIa KKS. We took an evolutionary approach better understand relationship KKS generation. BLAST...
Factor XII (FXII) is the zymogen of a plasma protease (FXIIa) that contributes to bradykinin generation by converting prekallikrein kallikrein (PKa). FXII conversion FXIIa autocatalysis or PKa-mediated cleavage enhanced when protein binds negatively charged surfaces such as polymeric orthophosphate. composed noncatalytic (heavy chain) and catalytic (light regions. The heavy chain promotes surface-binding surface-dependent activation but restricts not surface bound. From N terminus, contains...
Guided bone regeneration (GBR) scaffolds are futile in many clinical applications due to infection problems. In this work, we fabricated GBR with an anti-infective scaffold by ornamenting 2D single crystalline bismuth-doped nanohydroxyapatite (Bi-nHA) rods onto segmented polyurethane (SPU). Bi-nHA high aspect ratio was prepared without any templates. Subsequently, it introduced into unprecedented synthesized SPU matrix based on dual soft segments (PCL-b-PDMS) of poly(ε-caprolactone) (PCL)...
In many bacterial and eukaryotic systems, multiple cell fate decisions are activated by a single master regulator. Typically, the activities of regulators controlled posttranslationally in response to different environmental stimuli.
Spo0A in Bacillus subtilis is activated by phosphorylation (Spo0A~P) upon starvation and differentially controls a set of genes involved biofilm formation sporulation. The spo0A gene transcribed two distinct promoters, σA-recognized upstream promoter Pv during growth, σH-recognized downstream Ps starvation, appears to be autoregulated four Spo0A~P binding sites (0A1-4 boxes) localized between promoters. However, the autoregulatory mechanisms their impact on differentiation remain elusive....
Factor (F)XI is a zymogen that contributes to thrombin generation through activation of FIX. Patients with complete absence FXI are prone developing alloantibody inhibitors after replacement therapy. Acquired autoantibodies less common, and data regarding their mechanisms action lacking. We describe 2 patients severe acquired deficiency identify the domains which bind. prekallikrein (PK) homologs similar structures. prepared recombinant human PK, as well chimeric molecules in individual...
Abstract Schwartz–Jampel Syndrome (SJS) type 1 (OMIM #255800) is a rare autosomal recessive genetic disorder characterized by myotonia, chondrodysplasia, and distinctive mask-like facial appearance. This slowly progressive condition typically manifests in early infancy caused mutations the heparan sulfate proteoglycan 2 (HSPG2) gene, which encodes perlecan, crucial component of extracellular matrix. We report case SJS presenting with classic dysmorphic features characteristic musculoskeletal...
Background: Dyslipidaemia, the derangement of one or many lipoproteins is a major cause cardiovascular events, causing 2.6 million deaths per year globally.
PURPOSE It is projected that approximately 50,000 new cases of prostate cancer will be diagnosed in 2020 India. Survival has improved because the development effective drugs such as abiraterone acetate, but universal accessibility to treatment not always possible cost constraints lower- and middle-income countries. Recently, National Comprehensive Cancer Network (NCCN) included low-dose (250 mg/day) with food an alternative option full-dose (1,000 fasting. METHODS The Science Cost Consortium...
Total hip arthroplasty is a commonly performed surgery now-a-day. There are regional and racial variations in the stature of population worldwide. So there always need specific data for making best fit prosthesis.
Matrix metalloproteinases (MMPs) contribute to tumor invasion and microenvironment, hence are associated with bladder cancer risk. We therefore, tested whether polymorphisms in MMP genes modify the risk of (BC) smoke exposure modifies this Genotyping was performed 200 BC patients controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). MMP1-1607 2G/2G MMP7-181 GG genotype were increased (p < 0.001; OR, 3.04; 95% CI- 1.71-5.39 p, 0.005; 2.38; 1.30-4.34)...