A5101810030- Fungal and yeast genetics research
- Food composition and properties
- Enzyme Production and Characterization
- Phytase and its Applications
- Single-cell and spatial transcriptomics
- Cellular Mechanics and Interactions
- Cancer Cells and Metastasis
- Microbial Metabolites in Food Biotechnology
- Fermentation and Sensory Analysis
- Neuroscience and Neural Engineering
- Plant biochemistry and biosynthesis
- Heat Transfer Mechanisms
- Nanofluid Flow and Heat Transfer
- Plant-Microbe Interactions and Immunity
- 3D Printing in Biomedical Research
- Membrane Separation Technologies
- Mycorrhizal Fungi and Plant Interactions
- Pluripotent Stem Cells Research
- Tuberculosis Research and Epidemiology
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Biofuel production and bioconversion
Stanford University
2022-2025
Pakistan Institute of Medical Sciences
2021-2024
Quaid-i-Azam University
2017-2023
Abbottabad University of Science and Technology
2022-2023
Captain James A. Lovell Federal Health Care Center
2023
Rosalind Franklin University of Medicine and Science
2023
Superior University
2022
SUNY Upstate Medical University
2022
New York Institute of Technology
2022
Aga Khan University Hospital
2022
Molecular mechanisms underlying inflammation-associated breast tumor growth are poorly studied. S100A7, a pro-inflammatory molecule has been shown to enhance cancer and metastasis. However, the S100A7-mediated molecular in enhancing metastasis unclear.Human tissue plasma samples were used analyze expression of cPLA2, PGE2. S100A7-overexpressing or downregulated human metastatic cells evaluate downstream signaling mechanisms. Bi-transgenic mS100a7a15 overexpression, TNBC C3 (1)/Tag...
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related death. Hallmarks include desmoplasia with variable extracellular matrix (ECM) architecture and a complex microenvironment spatially defined tumor, stromal, immune populations. Nevertheless, role desmoplastic spatial organization in patient/tumor variability remains underexplored, which we elucidate using two technologies. First, quantify ECM patterning 437 patients, revealing...
Modulating mechanotransduction by inhibiting yes-associated protein (YAP) in mice yields wound regeneration without scarring. However, rodents are loose-skinned and fail to recapitulate key aspects of human repair. We sought elucidate the effects YAP inhibition red Duroc pig wounds, most human-like model show that one-time treatment with verteporfin, a inhibitor, immediately after wounding is sufficient prevent scarring drive pigs. By performing single-cell RNA sequencing (scRNA-seq) on...
Septins self-assemble into heteromeric rods and filaments to act as scaffolds modulate membrane properties. How cells tune the biophysical properties of septin control filament flexibility length, in turn size, shape, position higher-order structures, is not well understood. We examined how rod composition nucleotide availability influence physical septins such annealing, fragmentation, bundling, bending. found that complexes have symmetric termini, even when both Shs1 Cdc11 are coexpressed....
Efforts of controlling viral transmission began soon after the first cases coronavirus disease 2019 (COVID-19) infections were identified. Initial efforts related to contact precautions, hand hygiene, and mask-wearing; however, it was evident that a robust global immunization drive most effective way curb transmission. In United States, doses COVID-19 vaccines rolled out FDA granted emergency use authorization for severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine. What this also meant...
Septin proteins evolved from ancestral GTPases and co-assemble into hetero-oligomers cytoskeletal filaments. In Saccharomyces cerevisiae, five septins comprise two species of hetero-octamers, Cdc11/Shs1–Cdc12–Cdc3–Cdc10–Cdc10–Cdc3–Cdc12–Cdc11/Shs1. Slow GTPase activity by Cdc12 directs the choice incorporation Cdc11 vs Shs1, but many septins, including Cdc3, lack activity. We serendipitously discovered that guanidine hydrochloride rescues septin function in cdc10 mutants promoting assembly...
The current study was aimed to enzymatically modify maize flour by using amylase and pullulanase in combination for increasing the yield of resistant starch type III (EM-RSIII). enzymatic treatment imparts unique desired physicochemical properties including content, amylose milk, oil, water interaction ability. sensory analysis performed distributing questioners among individual results were interpreted 5-point hedonic scale. Result indicated an increase stability, milk absorption capacity...
To utilize wastes and residues sustainably excellently, there is a need to fend for efficient methods resources biogas production. Use of poultry waste production represents one the most important routes toward reaching global renewable energy targets. The current study involves microbial pretreatment chicken feather waste, followed by its co-digestion with rice husk green grocery in batch continuous reactors, respectively. Microbial feathers keratinase secreting Pseudomonas aeruginosa was...
Abstract In this study, novel enzymatically modified resistant starch type III (EM‐RSIII) derived drug loaded microspheres are developed for oral colon‐specific delivery of ciprofloxacin HCl, used as a model drug. EM‐RS is prepared using hydrolyzing enzymes amylase and pullulanase. The prebiotic effect EM‐RSIII successfully scrutinized promoting the growth probiotic bacteria, example, Lactobacillus reuteri . Drug‐loaded synthesized from through single emulsion evaporation method....
Abstract Purpose In drought-prone soils, plant growth-promoting rhizobacteria (PGPR) and arbuscular mycorrhizal fungus (AMF) might positively affect water uptake crop yield via rhizosphere interactions. Methods Sole combined additions of Bacillus amyloliquefaciens producing 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase Rhizophagus irregularis into rhizospheric soils were performed under well-watered (WW; 80% field capacity), moderate stress (MWS; 50% FWC) severe (SWS; 35% in...
ABSTRACTOverproduction of chicken feathers is responsible for serious environmental problems worldwide. The composition keratin protein, which resistant and difficult to monomerize. Utilization feather waste biogas organic fertilizer production can help combat threat address energy food shortage crisis. In this study, were hydrolyzed using the native isolated keratinolytic bacterial strain Pseudomonas aeruginosa-C1M. Reactor digestate, a by-product from hydrolyzate grocery waste, has been...
Pancreatic ductal adenocarcinoma (PDAC) represents one of the only cancers with an increasing incidence rate and is often associated intra- peri-tumoral scarring, referred to as desmoplasia. This scarring highly heterogeneous in extracellular matrix (ECM) architecture plays complex roles both tumor biology clinical outcomes that are not yet fully understood. Using hematoxylin eosin (H&E), a routine histological stain utilized existing workflows, we quantified ECM 85 patient samples assess...
In this study, polysulfone (PSf) nanocomposite membranes (NCM) have been fabricated by reinforcement with silica-modified zeolite (SiO 2 -MZ) and polyimide (PI)-SiO -MZ as inorganic (NC) fillers. To evaluate the improvement in structural, mechanical, thermal properties of PSf matrix, these nanofillers were incorporated systematically from 1 wt% to 10 wt%. Morphological analysis using transmission electron microscopy scanning shows better compatibility between PI-SiO nanofiller polymer matrix...
The increase in consumer demand for high-quality food products has led to growth the use of new technologies and ingredients. Resistant starch (RS) is a recently recognised source fibre received much attention its potential health benefits functional properties. However, knowledge about fate RS modulating complex intestinal communities, microbial members involved degradation, enhancement metabolites, role body physiology still limited. For this purpose, current study was designed ratify...
Background: Melasma is a significant cosmetic concern globally, affecting individuals across various ethnic backgrounds, particularly in South Asian populations. The condition's etiology complex, involving genetic, hormonal, and environmental factors such as sun exposure. Despite numerous treatment options, melasma remains challenging to manage effectively. Recent studies have explored the efficacy of tranexamic acid azelaic acid, both which target melanin synthesis pathway but through...
Abstract Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare with sparse tumor B-cells and favorable prognosis. Variant growth patterns of NLPHL, however, often show advanced stage, progression to T-cell/histiocyte-rich large B-cell (THRLBCL) worse We studied the microenvironment (TME) NLPHL THRLBCL using highplex imaging spatial profiling at single cell level. Our findings distinct differences in TME composition configuration that differ among typical variant THRLBCL. Typical...