A5050185927- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune and Inflammatory Disorders
- Trace Elements in Health
- Pressure Ulcer Prevention and Management
- Oral Health Pathology and Treatment
- Immune responses and vaccinations
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Inflammasome and immune disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Psoriasis: Treatment and Pathogenesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Dermatology and Skin Diseases
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Skin Diseases and Diabetes
- Cancer Immunotherapy and Biomarkers
NYU Langone Health
2024-2025
Icahn School of Medicine at Mount Sinai
2024-2025
Yale University
2022-2024
Abstract Sarcoidosis is an idiopathic inflammatory disorder that commonly treated with glucocorticoids. An imprecise understanding of the immunologic changes underlying sarcoidosis has limited therapeutic progress. Here in this open-label trial (NCT03910543), 10 patients cutaneous are tofacitinib, a Janus kinase inhibitor. The primary outcome change activity and morphology instrument (CSAMI) score after 6 months treatment. Secondary outcomes included internal organ involvement, molecular...
Inflammation is a hallmark of remitting-relapsing dermatological diseases. While large emphasis has been placed on adaptive immune cells as mediators relapse, evidence in epithelial and innate biology suggests that disease memory widespread. Here we bring to fore the concept inflammatory or non-specific training long-lived skin, highlighting epigenetic other mechanisms propagate at cellular level. We place these findings context Psoriasis, prototypic flaring known have localized underscore...
Modulating mechanotransduction by inhibiting yes-associated protein (YAP) in mice yields wound regeneration without scarring. However, rodents are loose-skinned and fail to recapitulate key aspects of human repair. We sought elucidate the effects YAP inhibition red Duroc pig wounds, most human-like model show that one-time treatment with verteporfin, a inhibitor, immediately after wounding is sufficient prevent scarring drive pigs. By performing single-cell RNA sequencing (scRNA-seq) on...
Dear Editor, We used publicly available single-cell RNA sequencing data to identify conserved tissue macrophage populations in human organs. Among the subsets, we found a rare population of metallothionein-expressing macrophages that are present all vital organs analyzed. deeply phenotype this subset and determine their localization liver. In first phase, collected from 10 livers,1 21 kidneys2 60 lungs,3 selected myeloid-lineage cells using published annotations lineage markers: CD68, S100,...