A5100783316- Autoimmune and Inflammatory Disorders
- Multiple Myeloma Research and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Chronic Myeloid Leukemia Treatments
- Skin Diseases and Diabetes
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Cell Adhesion Molecules Research
- Skin Protection and Aging
- Oral Health Pathology and Treatment
- Cutaneous lymphoproliferative disorders research
- Advanced Biosensing Techniques and Applications
- HIV/AIDS Research and Interventions
- Food Allergy and Anaphylaxis Research
- COVID-19 Clinical Research Studies
- Parvovirus B19 Infection Studies
- Advanced biosensing and bioanalysis techniques
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Yale University
2020-2024
Stony Brook University
2022-2023
Memorial Sloan Kettering Cancer Center
2023
Riverside University Health System - Medical Center
2022
Neurological Surgery
2022
Edward Via College of Osteopathic Medicine
2022
Cleveland Clinic
2022
Arrowhead Regional Medical Center
2022
Stony Brook School
2022
BD Biosciences (United States)
2015-2018
Abstract Sarcoidosis is an idiopathic inflammatory disorder that commonly treated with glucocorticoids. An imprecise understanding of the immunologic changes underlying sarcoidosis has limited therapeutic progress. Here in this open-label trial (NCT03910543), 10 patients cutaneous are tofacitinib, a Janus kinase inhibitor. The primary outcome change activity and morphology instrument (CSAMI) score after 6 months treatment. Secondary outcomes included internal organ involvement, molecular...
Cellular immune dysfunctions, which are common in intensive care patients, predict a number of significant complications. In order to effectively target treatments, clinically applicable measures need be developed detect dysfunction. The objective was confirm the ability cellular markers associated with dysfunction stratify risk secondary infection critically ill patients.Multi-centre, prospective observational cohort study patients four UK units. Serial blood samples were taken, and three...
Teclistamab, a B-cell maturation antigen (BCMA)- and CD3-targeting bispecific antibody, is an effective novel treatment for relapsed/refractory multiple myeloma (R/RMM), but efficacy in patients exposed to BCMA-directed therapies mechanisms of resistance have yet be fully delineated. We conducted real-world retrospective study commercial teclistamab, capturing both clinical outcomes immune correlates response cohort (n = 52) with advanced R/RMM. Teclistamab was highly overall rate (ORR) 64%,...
Skin keratinocytes are major mediators of host immune responses. The skin is also a target for immunologically based inflammation in many pathological states. Activation protein kinase C (PKC) can induce cutaneous inflammation, but the precise role each six PKC isoforms (alpha, delta, epsilon, eta, zeta, mu) that regulate normal homeostasis or contribute to pathology has not been clarified. We generated transgenic mice overexpress PKCalpha basal layer epidermis and outer root sheath hair...
Detection of individual cytokines in routine biopsies from patients with inflammatory skin diseases has the potential to personalize diagnosis and treatment selection, but this approach been limited by technical feasibility. We evaluate whether a chromogen-based RNA situ hybridization can be used detect druggable psoriasis atopic dermatitis. A series (n = 20) dermatitis 26) were stained using for IL4, IL12B (IL-12/23 p40), IL13, IL17A, IL17F, IL22, IL23A (IL-23 p19), IL31, TNF (TNF-α). NOS2...
Persistent erythema multiforme (PEM) is poorly understood and lacks effective therapies other than glucocorticoids.To report outcomes following treatment of PEM with Janus kinase (JAK) inhibition to elucidate cytokine drivers (EM).This was a retrospective case series 4 patients treated tofacitinib and/or upadacitinib in 2015 2021 at the dermatology clinics 2 major tertiary referral centers. Four consecutive refractory multiple approaches were treated. In 1 patient, skin biopsy specimens...
Sarcoidosis is an inflammatory disease characterized by the formation of granulomas in affected tissues. can occur nearly any organ; approximately one third patients have skin involvement, which occasionally only site disease.1 Cutaneous sarcoidosis commonly affects face and lead to significant morbidity. Angiolupoid a clinical variant, favors central face, especially nasal bridge, prominent telangiectasia overlying lesions.
Acral dermatoses, including hyperkeratotic palmoplantar eczema (HPE), psoriasis (PP), and mycosis fungoides palmaris et plantaris (MFPP), can be challenging to diagnose clinically histopathologically. In this setting, cytokine biomarkers may able help provide diagnostic clarity. We therefore evaluated interleukin (IL)-17A, interferon gamma (IFN-γ), IL-13 expression in PP, HPE, MFPP compared their profiles non-acral sites. utilized biopsy specimens from the Yale Dermatopathology database,...
A subset of patients with SARS-CoV-2 infection develop a cytokine release syndrome (CRS). Strategies to mitigate SARS-CoV-2-induced CRS are urgently needed. Many cytokines that play role in signal via the Janus kinase (JAK) and transducer activator transcription (STAT) pathway thus inhibited by JAK inhibitors. Compared IL-6 inhibitors, which currently being used for CRS, inhibitors offer potential advantage simultaneously suppressing activity plus other implicated including G-CSF, GM-CSF,...
Abstract In cell analysis, separate functional assays are often utilized to monitor multiple states. To simultaneously interrogate states, we have optimized simple flow cytometric panels that use up four parameters. As a result, more detailed biological correlations between distinct cellular functions can be obtained from single sample. this study, multiparameter were used analyze breast cancer lines MDA-MB-231 and MDA-MB-468 for differences in proliferation, apoptosis, DNA damage response...
Abstract Background The introduction of dolutegravir (DTG) in treating HIV has shown enhanced efficacy and tolerability. This study examined changes weight gain body mass index (BMI) at 6- 12-months after post-initiating antiretroviral therapy (ART), comparing people living with (PLHIV) on DTG-based regimens those non-DTG-based Malawi. Methods Retrospective cohort data from 40 public health facilities Malawi were used, including adult ART patients (aged ≥ 15 years) January 2017 to March...
Leukoderma, or hypomelanosis of the skin, can occur in response to various chemical and pharmacologic substances ranging from topical medications optic preparations systemic medications. In this case report, we present a 78-year-old man with history restless leg syndrome (RLS) who had been using rotigotine transdermal patches once daily for 1 year developed leukoderma on bilateral anterior shoulders area patch application. Histopathologic examination showed an absence melanocytes at...