A5039761622- Sperm and Testicular Function
- SARS-CoV-2 and COVID-19 Research
- Multiple Myeloma Research and Treatments
- Reproductive Biology and Fertility
- COVID-19 Clinical Research Studies
- Microbial infections and disease research
- Cancer Immunotherapy and Biomarkers
- Hematopoietic Stem Cell Transplantation
- Ovarian function and disorders
- Mitochondrial Function and Pathology
- CAR-T cell therapy research
- Mycobacterium research and diagnosis
- Immunodeficiency and Autoimmune Disorders
- Heat shock proteins research
- T-cell and B-cell Immunology
- Paraquat toxicity studies and treatments
- Tuberculosis Research and Epidemiology
- COVID-19 and healthcare impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Diabetes and associated disorders
- Selenium in Biological Systems
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pancreatic function and diabetes
Memorial Sloan Kettering Cancer Center
2023-2025
Kettering University
2023-2025
Columbia University
2019-2020
Barnard College
2020
Universidad de Zaragoza
2011-2016
Teclistamab, a B-cell maturation antigen (BCMA)- and CD3-targeting bispecific antibody, is an effective novel treatment for relapsed/refractory multiple myeloma (R/RMM), but efficacy in patients exposed to BCMA-directed therapies mechanisms of resistance have yet be fully delineated. We conducted real-world retrospective study commercial teclistamab, capturing both clinical outcomes immune correlates response cohort (n = 52) with advanced R/RMM. Teclistamab was highly overall rate (ORR) 64%,...
The mitochondria-associated degradation pathway (MAD) mediates ubiquitination and of mitochondrial outer membrane (MOM) proteins by the proteasome. We find that MAD, but not other quality-control pathways including macroautophagy, mitophagy, or chaperones proteases, is critical for yeast cellular fitness under conditions paraquat (PQ)-induced oxidative stress in mitochondria. Specifically, inhibition MAD increases PQ-induced defects growth quality decreases chronological lifespan. use mass...
Abstract Background: Multiple myeloma (MM), the second most common hematologic malignancy in US, has seen improved survival with therapeutic advancements. This presents an opportunity to enhance outcomes through diet and lifestyle. Poor dietary habits obesity are linked adverse MM its precursors—monoclonal gammopathy of undetermined significance (MGUS) smoldering multiple (SMM)—potentially mediated by intestinal dysbiosis which affects immune microenvironment. High Healthy Eating Index (HEI)...
Seminal plasma (SP) proteins support the survival of spermatozoa acting not only at membrane but also by inhibition capacitation, resulting in higher fertilizing ability. Among SP proteins, BSP (binder sperm) are most studied, since they may be useful for improvement semen diluents, storage and subsequent fertilization results. However, an updated detailed phylogenetic analysis protein superfamily has been carried out with all sequences described main databases. The update view shows first...
An enzyme-linked immunosorbent assay (ELISA) was performed for diagnosis of paratuberculosis in goats, using as antigen a protoplasmic extract (PPA-3). The test developed on the basis results obtained with two serum reference pools, positive and negative respectively. To avoid day-to-day variations, dilutions pool were included each plate to obtain an arbitrary system, transforming absorbance into immunoglobulin (Ig) G anti-Mycobacterium units. ELISA used sera groups animals. One group...
The mitochondria-associated degradation (MAD) pathway mediates ubiquitination and removal of mitochondrial outer membrane (MOM) proteins, targets them for by the proteasome. We find that MAD, but not other control pathways including macroautophagy, mitophagy, or chaperones proteases, is critical yeast cellular fitness under conditions paraquat (PQ) induced chronic, low-level oxidative stress in mitochondria. Specifically, inhibition MAD results increased PQ-induced defects growth quality,...
<div>Abstract<p>Coronavirus disease-19 (COVID-19) vaccine response data for patients with hematologic malignancy, who carry high risk severe COVID-19 illness, are incomplete. In a study of 551 malignancy leukemia, lymphoma, and multiple myeloma, anti–SARS-CoV-2 spike IgG titers neutralizing activity were measured at 1 3 months from initial vaccination. Compared healthy controls, had attenuated antibody months. Furthermore, markedly diminished capacity 26.3% month 43.6% months,...
<div>Abstract<p>Coronavirus disease-19 (COVID-19) vaccine response data for patients with hematologic malignancy, who carry high risk severe COVID-19 illness, are incomplete. In a study of 551 malignancy leukemia, lymphoma, and multiple myeloma, anti–SARS-CoV-2 spike IgG titers neutralizing activity were measured at 1 3 months from initial vaccination. Compared healthy controls, had attenuated antibody months. Furthermore, markedly diminished capacity 26.3% month 43.6% months,...