A5007992042- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Mitochondrial Function and Pathology
- Research on Leishmaniasis Studies
- Tissue Engineering and Regenerative Medicine
- DNA Repair Mechanisms
- Malaria Research and Control
- Photosynthetic Processes and Mechanisms
- Toxoplasma gondii Research Studies
- Mosquito-borne diseases and control
- Microtubule and mitosis dynamics
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Trypanosoma species research and implications
- Paraquat toxicity studies and treatments
- vaccines and immunoinformatics approaches
- Autophagy in Disease and Therapy
- Cloud Computing and Resource Management
- Calcium signaling and nucleotide metabolism
- Multicomponent Synthesis of Heterocycles
- Ferroelectric and Negative Capacitance Devices
- Pituitary Gland Disorders and Treatments
- Effects of Radiation Exposure
- Microbial Community Ecology and Physiology
- Curcumin's Biomedical Applications
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2025
Indian Institute of Toxicology Research
2025
Academy of Scientific and Innovative Research
2025
Jawaharlal Nehru University
2021-2024
Integral University
2024
Dr. Ram Manohar Lohia Institute of Medical Sciences
2024
The Sanskrit College and University
2023
UNSW Sydney
2019-2022
Cancer Institute of New South Wales
2021
University of Alberta
2019-2020
Rotenone, a widely used insecticide, has been shown to inhibit mammalian cell proliferation and depolymerize cellular microtubules. In the present study, effects of rotenone on assembly microtubules in relation its ability mitosis were analyzed. We found that inhibited HeLa MCF‐7 cells with half maximal inhibitory concentrations 0.2 ± 0.1 µ m 0.4 , respectively. At effective concentration range, depolymerized spindle both types. However, it had much stronger effect interphase compared cells....
Background. To eliminate malaria, surveillance for submicroscopic infections is needed. Molecular methods can detect but have not hitherto been amenable to implementation in programs. A portable loop-mediated isothermal amplification assay called RealAmp was assessed 2 areas of low malaria transmission.
The mitochondria-associated degradation pathway (MAD) mediates ubiquitination and of mitochondrial outer membrane (MOM) proteins by the proteasome. We find that MAD, but not other quality-control pathways including macroautophagy, mitophagy, or chaperones proteases, is critical for yeast cellular fitness under conditions paraquat (PQ)-induced oxidative stress in mitochondria. Specifically, inhibition MAD increases PQ-induced defects growth quality decreases chronological lifespan. use mass...
Charcot-Leyden crystals (CLCs) are hexagonal, colorless, bipyramidal structures derived from the aggregation of materials formed by disintegrating eosinophils. Necrotic cell debris and CLCs serve as indirect indicators parasitic infestation. Here, we highlight a case 49-year-old male patient who presented with high-grade fever right upper quadrant abdominal pain. Radiological findings showed hypodense liver lesion consistent an abscess. Fine-needle aspiration cytology (FNAC) demonstrated...
The purpose of this study was to prepare and characterize the complexes between curcumin (CU) phosphatidylcholine (PC) hydrogenated soya (HSPC) evaluate their anticancer activity. These CU-PC CU-HSPC (CU-PC-C CU-HSPC-C) were evaluated for various physical parameters like Fourier transform infrared spectroscopy, melting point, solubility, scanning electron microscopy in vitro drug release study. data confirmed formation phospholipids complexes. hemolysis showed that complex non-hemolytic....
The Chk2-mediated deoxyribonucleic acid (DNA) damage checkpoint pathway is important for mitochondrial DNA (mtDNA) maintenance. We show in this paper that mtDNA itself affects cell cycle progression. Saccharomyces cerevisiae rho0 cells, which lack mtDNA, were defective G1- to S-phase Deletion of subunit Va cytochrome c oxidase, inhibition F1F0 adenosine triphosphatase, or replacement all mtDNA-encoded genes with noncoding did not affect Thus, the progression defect cells caused by loss...
High linear energy transfer (LET) radiation or heavy ion such as carbon is used a method for advanced radiotherapy in the treatment of cancer. It has many advantages over conventional photon based using Co-60 gamma high X-rays from Linear Accelerator. However, charged particle therapy very costly. One way to reduce cost well irradiation effects on normal cells dose by enhancing sensitivity through use radiomodulator. PNKP (polynucleotide kinase/phosphatase) an enzyme which plays important...
Gastrulation is a stage in embryo development where three germ layers arise to dictate the human body plan. In vitro models of gastrulation have been demonstrated by treating pluripotent stem cells with soluble morphogens trigger differentiation. However, vivo multistage process coordinated through feedback between gradients and biophysical forces, multipotent epiblast transforming primitive streak followed layer segregation. Here, authors show how constraining hydrogel islands triggers...
Abstract Hijacking of host metabolic status by a pathogen for its regulated dissemination from the is prerequisite propagation infection. M. tuberculosis secretes an NAD + -glycohydrolase, TNT, to induce necroptosis hydrolyzing Nicotinamide adenine dinucleotide (NAD ). Herein, we expressed TNT in macrophages and erythrocytes; cells malaria parasite respectively, found that it reduced levels thereby induced eryptosis resulting premature pathogen. Targeting or interferes with reduction...
Mesenchymal stem cell therapy has suffered from wide variability in clinical efficacy, largely due to heterogeneous starting populations and large-scale death during after implantation. Optimizing the manufacturing process led reproducible that can be cryopreserved for applications. Nevertheless, ensuring a state persists cryopreservation remains significant challenge, is necessary ensure outcomes. Here we demonstrate how matrix-conjugated hydrogel culture materials normalize population of...
SUMOylation is one of the post-translational modifications that have recently been described as a key regulator various cellular, nuclear, metabolic, and immunological processes. The process involves modification or more lysine residues target proteins by conjugation ubiquitin-like, small polypeptide known SUMO for their degradation, stability, transcriptional regulation, cellular localization, transport. Herein, first time, we report involvement host pathway in infection Leishmania donovani...
Human adipocytes are a source of tissue-regenerative multipotent stem cells.
The role of social media (SM) in the travel process cannot be ignored. With a steady growth Indian industry, we find an upsurge number Indians travelling to outbound destinations. This research aims explore behaviour and usage SM for purposes by leisure travellers during their entire process. It adopts qualitative approach. Semi structured interviews were conducted with 30 respondents, who had travelled internationally over past one year from period study. A thematic analysis was identify...
Palmitoylation is an essential post-translational modification in Leishmania donovani, catalyzed by enzymes called palmitoyl acyl transferases (PATs) and has role virulence. Due to the toxicity promiscuity of known PAT inhibitors, identification new molecules needed. Herein, we identified a specific novel de novo peptide inhibitor, PS1, against PAT6 donovani transferase (LdPAT6). To demonstrate inhibition LdPAT6 employed bacterial orthologue system metabolic labeling-coupled click chemistry...
Background: Button mushrooms have long been esteemed for their significant contribution to addressing various human ailments. Their delectable taste, rich flavor and enticing aroma render them a coveted centerpiece on every dining table. However, inherent susceptibility decay, owing rapid transpiration rate thin epidermis, typically results in spoilage within mere two days post-harvest. Methods: The current experiments was done at Banaras Hindu University investigate the effect of different...
Paraganglioma are rare tumor derived from either parasympathetic or sympathetic paraganglia. These tumors have wide spectrum of clinical presentation, and variable anatomic distribution, however their location in the neck skull base is common but a sporadic rare. We presenting case 32 yr female with history severe systemic hypertension mid occipital soft tissue swelling. Her radio-imaging study revealed an extra-dural mass lesion minimal bony erosion. Peroperative course was associated...
The interplay between host and parasite determines burden disease outcome. Parasite exploits signaling pathways like p38-MAPK for its survival pathogenesis. NR-7h, a proteolysis-targeting chimera (PROTAC) targeting human was used to assess p38-MAPK's role in Leishmania donovani Plasmodium falciparum infection their respective hosts. NR-7h degraded time- dose-dependent manner. Degradation of by reduced load cells dose-dependently, implicating the survival. modulation cytokine profiling...
The mitochondria-associated degradation (MAD) pathway mediates ubiquitination and removal of mitochondrial outer membrane (MOM) proteins, targets them for by the proteasome. We find that MAD, but not other control pathways including macroautophagy, mitophagy, or chaperones proteases, is critical yeast cellular fitness under conditions paraquat (PQ) induced chronic, low-level oxidative stress in mitochondria. Specifically, inhibition MAD results increased PQ-induced defects growth quality,...
ABSTRACT The rapid emergence of P. falciparum-resistant strains raises an urgent need to find new antimalarial drug candidates. This study reports the rational repositioning anti-Hepatitis C Virus drug, Alisporivir, a non-immunosuppressive analog cyclosporin A (CsA) against multiple, drug-resistant falciparum . Alisporivir being non-hemolytic has been proven be better than CsA. Indeed, our also demonstrated same. inhibited chloroquine-sensitive parasite growth with IC 50 196.6nM....