A5090895186- Primate Behavior and Ecology
- Veterinary Pharmacology and Anesthesia
- Anesthesia and Sedative Agents
- Olfactory and Sensory Function Studies
- Antibiotics Pharmacokinetics and Efficacy
- Advanced Neuroimaging Techniques and Applications
- Stress Responses and Cortisol
- Animal Behavior and Welfare Studies
- Memory and Neural Mechanisms
- Human-Animal Interaction Studies
- HIV Research and Treatment
- Streptococcal Infections and Treatments
- Genomics and Phylogenetic Studies
- Neonatal and fetal brain pathology
- Functional Brain Connectivity Studies
- Marine animal studies overview
- Alzheimer's disease research and treatments
- Glioma Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
- Neuroblastoma Research and Treatments
- Animal Nutrition and Physiology
- Advanced Chemical Sensor Technologies
- Animal Disease Management and Epidemiology
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
Kyoto University
2016-2025
Institute of Primate Research
2010-2024
Saitama University
2021
Aichi University
2012
Facial expressions are subtle cues, central for communication and conveying emotions in mammals. Traditionally, facial have been classified as a whole (e.g. happy, angry, bared-teeth), due to automatic face processing the human brain, i.e., humans categorise globally, but not aware of or isolated cues such an eyebrow raise. Moreover, same configuration lip corners pulled backwards exposing teeth) can convey widely different information depending on species humans: happiness; chimpanzees:...
Developmental prolongation is thought to contribute the remarkable brain enlargement observed in modern humans ( Homo sapiens ). However, developmental trajectories of cerebral tissues have not been explored chimpanzees Pan troglodytes ), even though they are our closest living relatives. To address this lack information, development was tracked growing during infancy and juvenile stage, using three-dimensional magnetic resonance imaging compared with that rhesus macaques Macaca mulatta...
The Facial Action Coding System (FACS) is an objective observation tool for measuring human facial behaviour. It avoids subjective attributions of meaning by objectively independent movements linked to muscles, called Units (AUs). FACS has been adapted 11 other taxa, including most apes, macaques and domestic animals, but not yet gorillas. To carry out cross species studies expressions within beyond gorillas need be included in such studies. Hence, we developed the GorillaFACS Gorilla spp ....
ABSTRACT Background Common marmosets ( Callithrix jacchus ) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) effective predicted plasma injectable (propofol) were measured for optimization in marmosets. Methods The concentrations (MACs) several stimulations (nociceptive stimulation, endotracheal intubation, non‐painful direct stimulation),...
Abstract Background Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disorder (LSD) caused by recessive mutations in the α-L-iduronidase ( IDUA ) gene. Enzyme replacement therapy (ERT) utilizing terminal mannose-6-phosphate (M6P)-carrying N -glycans attached to therapeutic enzymes produced mammalian cell lines has been clinically applied several LSDs. Recent studies suggested unidentified delivery pathway mediated sialic acid-containing -glycans. However, more...
How brains develop during early life is one of the most important topics in neuroscience because it underpins neuronal functions that mature this period. A comparison neurodevelopmental patterns among humans and nonhuman primates essential to infer evolutional changes neuroanatomy account for higher-order brain functions, especially those specific humans. The corpus callosum (CC) major white matter bundle connects cerebral hemispheres, therefore, relates a wide variety functions. In humans,...
We are flat-faced hominins with an external nose that protrudes from the face. This feature was derived in genus Homo, along facial flattening and reorientation to form a high nasal cavity. The passage conditions inhaled air terms of temperature humidity match required lung, its anatomical variation is believed be evolutionarily sensitive ambient atmospheric given habitat. In this study, we used computational fluid dynamics (CFD) three-dimensional topology models under same simulation...
Facial expressions are complex and subtle signals, central for communication emotion in social mammals. Traditionally, facial have been classified as a whole, disregarding small but relevant differences displays. Even with the same morphological configuration different information can be conveyed depending on species. Due to hardwired processing of faces human brain, humans quick attribute emotion, difficulty registering movement units. The well-known FACS (Facial Action Coding System) is...
Miyabe‐Nishiwaki, T., Masui, K., Kaneko, A., Nishiwaki, Nishio, Kanazawa, H. Evaluation of the predictive performance a pharmacokinetic model for propofol in Japanese macaques ( Macaca fuscata ). J. vet. Pharmacol. Therap. 36 , 169–173. Propofol is short‐acting intravenous anesthetic used induction/maintenance anesthesia. The objective this study was to assess population (PPK) during step‐down infusion propofol. Five male were immobilized with ketamine (10 mg/kg) and atropine (0.02 mg/kg). A...
Six strains, TKU 25, 28, 30, 31(T), 33 and 34, were isolated from the oral cavity of a chimpanzee (Pan troglodytes). Colonies strains grown on Mitis-Salivarius agar similar in morphology to that Streptococcus mutans. The novel Gram-stain-positive, facultatively anaerobic cocci lacked catalase activity. Analysis partial 16S rRNA gene sequences these isolates showed most closely related strain was type S. mutans (96.4 %). next devriesei (94.5 %) downei (93.9 These could be distinguished by...
Abstract We discovered a lethal hemorrhagic syndrome arising from severe thrombocytopenia in Japanese macaques kept at the Primate Research Institute, Kyoto University. Extensive investigation identified that simian retrovirus type 4 (SRV-4) was causative agent of disease. SRV-4 had previously been isolated only cynomolgus which it is usually asymptomatic. consider crossed so-called species barrier between and macaques, leading to extremely acute symptoms latter. Infectious agents cross...
Rationale Estimation of the stable isotopic offsets between tissue and diet is important for dietary reconstructions. Although studies chimpanzees ( Pan troglodytes ) are increasing, in have never been studied. In this study, carbon nitrogen offset values hair feces were measured 13 captive first time. Methods All consumed food items quantities recorded each individual 1 week. Food samples typically collected three times, was 3 weeks after experimental week, ad libitum during The isotope...
Abstract Helicobacter pylori cagA -positive strains are critically involved in the development of gastric cancer. Upon delivery into epithelial cells via type IV secretion, -encoded CagA interacts with and thereby perturbs pro-oncogenic phosphatase SHP2 polarity-regulating kinase PAR1b tyrosine-phosphorylated EPIYA-C/D segment CM sequence, respectively. Importantly, sequences spanning these binding regions exhibit variations among proteins, which influence pathobiological/oncogenic potential...
Abstract Common marmosets are promising laboratory animals for the study of higher brain functions. Although there many opportunities to use sedatives and anesthetics in resting function measurements marmosets, their effects on resting-state network remain unclear. In this study, or such as midazolam, dexmedetomidine, co-administration isoflurane propofol, alfaxalone, isoflurane, sevoflurane common were evaluated using independent component analysis, dual regression graph-theoretic analysis;...
Three strains TKU9, TKU49 and TKU50(T) , were isolated from the oral cavities of chimpanzees (Pan troglodytes). The isolates all gram-positive, facultative anaerobic cocci that lacked catalase activity. Analysis partial 16S rRNA gene sequences showed most closely related species was Streptococcus infantis (96.7%). next to S. rubneri, mitis, peroris australis (96.6 96.4%). Based on rpoB gyrB sequences, clustered with other member mitis group. Enzyme activity sugar fermentation patterns...
Human fetuses at term are large relative to the dimensions of maternal birth canal, implying that their can be associated with difficulties. The tight passage through human canal lead devastating outcomes if becomes obstructed, including and fetal death. Although macaques have accommodate similarly fetuses, canals, it was not known whether macaque mothers face difficulties similar humans. Based on 27 y demographic data from a semi-free-ranging, closely monitored population Japanese ( Macaca...