A5011128606- Genetic and phenotypic traits in livestock
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Meat and Animal Product Quality
- Animal Nutrition and Physiology
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- Animal Genetics and Reproduction
- Genetic Mapping and Diversity in Plants and Animals
- Muscle activation and electromyography studies
- Reproductive Physiology in Livestock
- X-ray Diffraction in Crystallography
- Microbial infections and disease research
- Crystallization and Solubility Studies
- Axon Guidance and Neuronal Signaling
- Molten salt chemistry and electrochemical processes
- Neurobiology and Insect Physiology Research
- Genetics and Neurodevelopmental Disorders
- Effects of Environmental Stressors on Livestock
- Retinal Development and Disorders
- Metal and Thin Film Mechanics
- CRISPR and Genetic Engineering
- Intermetallics and Advanced Alloy Properties
- Blood groups and transfusion
- Motor Control and Adaptation
Kyoto University
2014-2025
Kanazawa Medical University
2025
Kanazawa University
2025
Japan Science and Technology Agency
2005-2023
Japan Agency for Medical Research and Development
2022
Institute of Primate Research
2002-2019
National Institute of Advanced Industrial Science and Technology
2002-2015
Tokyo University of Agriculture
1979-2012
University of Tsukuba
2009
National Livestock Breeding Center
2007
The question of how intensive motor training restores function after brain damage or stroke remains unresolved. Here we show that the ipsilesional ventral premotor cortex (PMv) and perilesional primary (M1) rhesus macaque monkeys are involved in recovery manual dexterity a lesion M1. A focal hand digit area M1 was made by means ibotenic acid injection. This initially caused flaccid paralysis contralateral but followed functional movements, including precision grip, during course daily...
Molecular maps of the human brain alone do not inform us features unique to humans. Yet, identification these is important for understanding both evolution and nature cognition. Here, we approached this question by analyzing gene expression H3K27ac chromatin modification data collected in eight regions humans, chimpanzees, gorillas, a gibbon, macaques. An analysis spatial transcriptome trajectories across four primate species revealed 1851 genes showing human-specific differences one or...
1. The role of intracortical GABAergic inhibition in the performance hand movements was studied macaque monkeys while they performed two behavioral tasks: a raisin pick-up test and visual reaction-time task. A gamma-aminobutyric acid (GABA) agonist, muscimol (MUS; 1-5 microgram), an antagonist, bicuculline methiodide (BMI, 1-10 micrograms), were injected at various sites precentral motor cortex (MC), which single-unit activity related to manual aspects 2. Manual dexterity task severely...
To investigate the effects of postlesion training on motor recovery, we compared recovery macaque monkeys that had received intensive with those no after a lesion primary cortex (M1). An ibotenic acid in M1 digit area resulted impairment hand function, complete loss movement. In undergone daily (1 h/day, 5 days/wk) lesion, behavioral indexes used to evaluate manual dexterity recovered same level as prelesion period 1 or 2 mo period. Relatively independent movements, including precision grip...
An experiment was carried out to investigate whether thick albumen is essential for the normal development of chick embryo. Fertilized ova recovered from oviducts hens were cultured in vitro and transferred recipient eggshells with (method A) or without B) replacement by thin albumen. Embryos freshly laid eggs C) E) diluted solution salts D). then incubated until hatching. The rates hatching embryos 34.4%, 16.2%, 50.0%, 6.9-26.7%, 47.5% methods A, B, C, D, E, respectively. Thus rate...
By using the developing monkey brain as a model for human development, we investigated expression pattern of FOXP2 gene, member FOX family transcription factors in brain, and compared its with PBX3, MEIS2, FOXP1. We observed mRNA several structures, including striatum, islands Calleja other basal forebrain regions, cerebral cortex, thalamus. was preferentially expressed striosomal compartments during striatal development. The transient developmentally down-regulated topographical order....
Dexterous hand movements can be restored with motor rehabilitative training after a lesion of the lateral corticospinal tract (l-CST) in macaque monkeys. To maximize effectiveness, optimal time to commence such must determined. We conducted behavioral analyses and compared recovery dexterous between monkeys which was initiated immediately l-CST (early-trained monkeys) those 1 mo (late-trained monkeys). The performance evaluated by food retrieval tasks. In early-trained monkeys, success rate...
Abstract Background Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disorder (LSD) caused by recessive mutations in the α-L-iduronidase ( IDUA ) gene. Enzyme replacement therapy (ERT) utilizing terminal mannose-6-phosphate (M6P)-carrying N -glycans attached to therapeutic enzymes produced mammalian cell lines has been clinically applied several LSDs. Recent studies suggested unidentified delivery pathway mediated sialic acid-containing -glycans. However, more...
To investigate the neural basis for functional recovery of cerebral cortex following spinal cord injury, we measured expression growth-associated protein 43 (GAP-43), which is involved in process synaptic sprouting. We determined GAP-43 mRNA levels sensorimotor cortical areas macaque monkeys with a unilateral lesion lateral corticospinal tract (l-CST) at C4/C5 level cervical and compared them corresponding regions intact monkeys. Lesioned recovered finger dexterity during first months after...
The long history of neuroscience has accumulated information about numerous types neurons in the brain various organisms. Because such have been reported diverse publications without controlled format, it is not easy to keep track all known a particular nervous system. To address this issue we constructed an online database called Flybrain Neuron Database (Flybrain NDB), which serves as platform collect and provide published so far Drosophila melanogaster. Projection patterns identified...
Abstract In embryogenesis, avian primordial germ cells (PGCs) circulate temporarily in the blood vessels at stages 10–15 (Hamburger and Hamilton, 1951), before reaching gonads. an attempt to transfer cloned genes into PGCs, liposome consisting of reporter plasmid DNA N‐[1‐(2,3‐Dioleoyloxy)propyl]‐N, N, N‐trimethyl‐ammoniummethylsulfate was injected marginal veins embryos 11‐‐15. As plasmids, pRSVZ pAcZ harboring Escherichia coli lacZ gene driven, respectively, by Rous sarcoma virus (RSV)...
Abstract 1. Quail‐chick chimaeras were produced by injecting dissociated quail blastoderm cells into chick embryos. 2. Quail blastoderms removed from the yolk and dispersed trypsin treatment or pipetting. The cell suspension (1 to 5 μl) was injected subgerminal cavity of unincubated embryos then cultured in recipient eggshells. 3. adhered embryonic cells. rates hatching 8.6% (38 chicks 441 eggs) 40.3% (48 119 when volumes 3 μl 1 μl, respectively. 4. Seven out 86 hatched birds clearly...
Abstract The configuration of the supralaryngeal vocal tract depends on nonuniform growth oral and pharyngeal portion. human pharynx develops to form a unique configuration, with epiglottis losing contact velum. This from great descent larynx relative palate, which is accomplished through both laryngeal skeleton hyoid palate. Chimpanzees show processes descent, as in humans, but evolutionary path before divergence chimpanzee lineages unclear. development six living Japanese macaque monkeys,...
Recent transcriptome analyses have shown that long non-coding RNAs (ncRNAs) play extensive roles in transcriptional regulation. In particular, we reported promoter-associated ncRNAs (pancRNAs) activate the partner gene expression via local epigenetic changes. Here, identify thousands of genes under pancRNA-mediated activation five mammalian species common. mouse, 1) pancRNA-partnered confined their pattern to certain tissues compared pancRNA-lacking genes, 2) pancRNAs was significantly...
Abstract The cellular distribution of SPP1 , which we recently identified as a gene with greater expression in the macaque primary motor cortex than premotor or prefrontal cortices, was examined rhesus macaque, common marmoset, and rat brains. In situ hybridization histochemistry revealed that mRNA expressed specifically pyramidal neurons layer V sensorimotor macaque. These mRNA‐positive were most abundant area, followed by Brodmann area 5 supplementary accordance corticospinal neurons....