A5051006135- Cancer-related molecular mechanisms research
- Genomics and Phylogenetic Studies
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Genetic diversity and population structure
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Developmental Biology and Gene Regulation
- Marine and coastal plant biology
- Pluripotent Stem Cells Research
- Chromosomal and Genetic Variations
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Evolution and Paleontology Studies
- Physiological and biochemical adaptations
- Marine Bivalve and Aquaculture Studies
- Echinoderm biology and ecology
- Animal Genetics and Reproduction
- Circular RNAs in diseases
- Gene expression and cancer classification
- Fish biology, ecology, and behavior
- Genetics, Aging, and Longevity in Model Organisms
- Adrenal and Paraganglionic Tumors
Tohoku University
2024-2025
RIKEN Center for Biosystems Dynamics Research
2018-2024
The University of Tokyo
2017-2019
Kyushu University
2002-2017
Kyoto University
2010-2015
Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and often assumed to be causally associated with organismal innovations radiations. The 2R hypothesis suggests two WGD events (1R 2R) occurred during early vertebrate evolution. However, the timing of relative divergence gnathostomes (jawed vertebrates) cyclostomes (jawless hagfishes lampreys) unresolved whether these underlie phenotypic diversification remains elusive. Here we present...
The majority of non-coding RNAs (ncRNAs) involved in mRNA metabolism mammals have been believed to downregulate the corresponding expression level a pre- or post-transcriptional manner by forming short long ncRNA-mRNA duplex structures. Information on non-duplex-forming ncRNAs is now also rapidly accumulating. To examine directional properties transcription at whole-genome level, we performed RNA-seq analysis mouse and chimpanzee tissue samples.We found that there only about 1% genome where...
Rett syndrome (RTT) is a neurodevelopmental disorder caused by MECP2 mutations. Although emerging evidence suggests that MeCP2 deficiency associated with dysregulation of mechanistic target rapamycin (mTOR), which functions as hub for various signaling pathways, the mechanism underlying this association and molecular pathophysiology RTT remain elusive. We show here promotes posttranscriptional processing particular microRNAs (miRNAs) component microprocessor Drosha complex. Among...
In mice, zygotic activation occurs for a wide variety of genes, mainly at the 2-cell stage. Long noncoding RNAs (lncRNAs) are increasingly being recognized as modulators gene expression. this study, directional RNA-seq MII oocytes and embryos identified more than 1000 divergently transcribed lncRNA/mRNA pairs. Expression these bidirectional promoter-associated (pancRNAs) was strongly associated with upregulation their cognate genes. Conversely, knockdown three abundant pancRNAs led to...
Abstract Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development this unique transformation remains to be clarified. Here we report newly sequenced genomes, developmental transcriptomes, proteomes diverse echinoderms including green sea urchin ( L. variegatus ), cucumber A. japonicus with particular emphasis on sister earliest-diverged echinoderms, feather star...
Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development caused by mutations in MECP2; however, the underlying mechanism remains elusive. We know from previous work that MeCP2 facilitates processing of specific microRNA, miR-199a, associating Drosha complex to regulate neuronal functions. Here, we show MeCP2/miR-199a axis regulates neural stem/precursor cell (NS/PC) differentiation. A shift occurs astrocytic differentiation MeCP2- and miR-199a-deficient NS/PCs...
Abstract Skeletal forms in vertebrates have been regarded as good models of morphological diversification. Fish fin are greatly diversified, and their bone structure is classified into soft rays spiny rays. In fish evolution, spiny-ray morphologies known to be sometimes extremely modified; however, it remains unknown how the developmental mechanisms spiny-rays contributed By using rainbowfish Melanotaenia praecox for examination extracellular matrix (ECM) cell dynamics development, we...
Whole genome duplications (WGDs) are major events that drastically reshape architecture and causally associated with organismal innovations radiations 1 . The 2R Hypothesis suggests two WGD (1R 2R) occurred during early vertebrate evolution 2, 3 However, the veracity timing of event relative to divergence gnathostomes (jawed vertebrates) cyclostomes (jawless hagfishes lampreys) is unresolved 4–6 whether these underlie phenotypic diversification remains elusive 7 Here we present inshore...
Understanding the general trends in developmental changes during animal evolution, which are often associated with morphological diversification, has long been a central issue evolutionary biology. Recent comparative transcriptomic studies revealed that gene expression profiles of mid-embryonic period tend to be more evolutionarily conserved than those earlier or later periods. While hourglass-like divergence processes demonstrated variety groups such as vertebrates, arthropods, and...
Abstract The relationship between development and evolution has been a central theme in evolutionary developmental biology. Across the vertebrates, most highly conserved gene expression profiles are found at mid-embryonic, organogenesis stages, whereas those earlier later stages more diverged. This hourglass-like pattern of divergence does not necessarily rule out possibility that evolutionarily derived appear development; however, no molecular-level evidence such phenomenon reported. To...
In this study, we comprehensively searched for fish-specific genes in gnathostomes that contribute to development of the fin, a trait. Many previous reports suggested animal group-specific are often important traits. Clarifying roles fin gnathostomes, example, can help elucidate mechanisms underlying formation We first identified 91 by comparing gene repertoire 16 fish and 35 tetrapod species. RNA-seq analysis narrowed down candidates 33 were expressed developing pectoral fin. analyzed...
Recent transcriptome analyses have shown that long non-coding RNAs (ncRNAs) play extensive roles in transcriptional regulation. In particular, we reported promoter-associated ncRNAs (pancRNAs) activate the partner gene expression via local epigenetic changes. Here, identify thousands of genes under pancRNA-mediated activation five mammalian species common. mouse, 1) pancRNA-partnered confined their pattern to certain tissues compared pancRNA-lacking genes, 2) pancRNAs was significantly...
Abstract Whole genome duplications (WGDs) are major events that drastically reshape architecture and causally associated with organismal innovations radiations 1 . The 2R Hypothesis suggests two WGD (1R 2R) occurred during early vertebrate evolution 2,3 However, the veracity timing of event relative to divergence gnathostomes (jawed vertebrates) cyclostomes (jawless hagfishes lampreys) is unresolved 4-6 whether these underlie phenotypic diversification remains elusive 7 Here we present...
Species retaining ancestral features, such as species called living fossils, are often regarded less derived than their sister groups, but discussions usually based on qualitative enumeration of conserved traits. This approach creates a major barrier, especially when quantifying the degree phenotypic evolution or derivedness, since it focuses only commonly shared traits, and newly acquired lost traits overlooked. To provide potential solution to this problem, for inter-species comparison...
During mammalian development, androgen circulates throughout the body and masculinizes several tissues through endocrinological pathways by binding receptor (AR).At onset of brain masculinization/defeminization, androgen-AR system functions in a region-specific manner and, even adulthood, this affects transcription certain set genes.The system, together with coregulators such as histone modifiers, epigenetically regulates many kinds genes to express phenotype cell according cell's own...
Masahiro Uesaka is a Guest Co-editor of this special issue on recapitulation. Website: https://www.researchgate.net/profile/Masahiro_Uesaka With whom and where did you study? After I finished my Bachelor Science in Biology at Kyoto University, joined Dr. Kiyokazu Agata's laboratory. For PhD, studied species-specific long noncoding RNAs their regulatory roles epigenetics, working with Drs. Takuya Imamura Kinichi Nakashima. completing PhD moved to the University Tokyo, worked EvoDevo research...