A5102519666- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Herpesvirus Infections and Treatments
- Animal Disease Management and Epidemiology
- Diphtheria, Corynebacterium, and Tetanus
- Botulinum Toxin and Related Neurological Disorders
- Clostridium difficile and Clostridium perfringens research
Kyoto University
2023-2025
Abstract Background Spontaneous remission once a retroviral infection has been established does not occur and persists lifelong. Methods Stored blood samples obtained from simian T-cell leukemia virus type 1 (STLV-1)-infected Japanese macaque (JM; Macaca fuscata) mothers their offspring during long-term follow-up as well periodic health checkups were analyzed for proviral DNA levels, anti-STLV-1 antibody titer, sequence, viral transcription, clonality in peripheral mononuclear cells. Results...
Primate T-cell leukemia virus type 1 (PTLV-1) is classified into a genus Deltaretrovirus that persists in infected primates and can lead to adult T cell inflammatory diseases. Unlike hepatitis viruses, it remains unclear whether PTLV-1 could cause occult infection, rare latent infection status characterized by detectable provirus without accompanying antibody responses. A longitudinal study was conducted characterize mother-to-child transmission of simian (STLV-1) Japanese monkeys (JMs)....
A tetanus outbreak occurred during 2014-2015 in the rhesus macaques reared an open enclosure our facility. As soil of facility was suspected to be contaminated with Clostridium tetani spores, there a risk further occurring among macaques. To protect them from tetanus, toxoid vaccination recommended; however, vaccinated elderly animals might not effectively protected due insufficient humoral immune responses. Hence, we evaluated dynamics antibody responses all age groups two-dose at 1-year...