A5008720237- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Anesthesia and Pain Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac, Anesthesia and Surgical Outcomes
- Intensive Care Unit Cognitive Disorders
- Spinal Fractures and Fixation Techniques
- Meningioma and schwannoma management
- Optical Imaging and Spectroscopy Techniques
- Pain Management and Placebo Effect
- Transcranial Magnetic Stimulation Studies
- Acute Ischemic Stroke Management
- Cancer, Stress, Anesthesia, and Immune Response
- Nausea and vomiting management
- Veterinary Pharmacology and Anesthesia
- Neurosurgical Procedures and Complications
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Trauma and Emergency Care Studies
- Injury Epidemiology and Prevention
- Airway Management and Intubation Techniques
- Scoliosis diagnosis and treatment
- Empathy and Medical Education
- Neurological Complications and Syndromes
University Medical Center Groningen
2013-2024
University of Groningen
2009-2023
Dialyse Centrum Groningen
2022
The Composite Variability Index (CVI), derived from the electroencephalogram, was developed to assess antinociception-nociception balance, whereas Bispectral (BIS) hypnotic state during anesthesia. We studied relationships between these indices, level of hypnosis (BIS level), and antinociception (predicted remifentanil effect-site concentrations, CeREMI) before after stimulation. Also, we measured their association with movement in response a noxious stimulus.We randomized 120 patients one...
Muscle-recorded transcranial electrical stimulation motor-evoked potentials (mTc-MEPs) are used to assess the spinal cord integrity. They commonly recorded with subcutaneous needle or surface electrodes, but different characteristics of mTc-MEP signals two types electrodes have not been formally compared yet. In this study, mTc-MEPs were simultaneously from tibialis anterior (TA) muscles using and in 242 consecutive patients. Elicitability, motor thresholds, amplitude, area under curve...
In the NERFACE study part I, characteristics of muscle transcranial electrical stimulation motor evoked potentials (mTc-MEPs) recorded from tibialis anterior (TA) muscles with surface and subcutaneous needle electrodes were compared. The aim this (NERFACE II) was to investigate whether use non-inferior in detecting mTc-MEP warnings during spinal cord monitoring. mTc-MEPs simultaneously TA electrodes. Monitoring outcomes (no warning, reversible irreversible complete loss amplitude)...
Current electroencephalogram (EEG)-derived measures provide information on cortical activity and hypnosis but are less accurate regarding subcortical activity, which is expected to vary with the degree of antinociception. Recently, neurophysiologically based EEG input (CI) state (CS) have been shown be prospective indicators analgesia/antinociception hypnosis, respectively. In this study, we compared CI an alternate measure CS, composite (CCS), Bispectral Index (BIS) another recently...
The effect of anesthetic management (general anesthesia [GA], conscious sedation, or local anesthesia) on functional outcome and the role blood pressure during endovascular treatment (EVT) for acute ischemic stroke is under debate. We aimed to determine whether hypotension EVT GA associated with at 90 days.We retrospectively collected data from patients a proximal intracranial occlusion anterior circulation treated GA. primary was distribution modified Rankin Scale days. Hypotension defined...
The aim of endovascular treatment (EVT) for acute ischaemic stroke is to relieve the cerebral tissue hypoxia in area supplied by occluded artery. Near-infrared spectroscopy (NIRS) monitoring developed assess regional oxygen haemoglobin saturation (rSO2). We aimed investigate whether NIRS can detect inter- and intra-hemispheric rSO2 differences during EVT.In this prospective, observational study, patients undergoing EVT a proximal intracranial occlusion anterior circulation between May 2019...
For high-risk spinal surgeries, intraoperative neurophysiological monitoring (IONM) is used to detect and prevent neurological injury. The motor tracts are monitored by recording analyzing muscle transcranial electrical stimulation evoked potentials (mTc-MEPs). A mTc-MEP amplitude decrease of 50-80% the most common warning criterion for possible However, these criteria often result in false positive warnings. False positives may be caused inadequate depth anesthesia blood pressure on...
BACKGROUND: Clinicians can optimize propofol titration by using 2 sources of pharmacodynamic (PD) information: the predicted effect-site concentration for (Ce prop ) and electroencephalographically (EEG) measured drug effect. Relation between these should be time independent, that is, perfectly synchronized. In reality, various issues corrupt independency, leading to asynchrony or, in other words, hysteresis. This lead conflicting information, making effective dosing challenging. this study,...
Objective It is challenging for rescuers to perform cardiopulmonary resuscitation (CPR) onboard lifeboats, particularly during rough weather. A mechanical chest compression device (MCD) may provide better quality compressions. The aim of this study was compare the compressions performed by lifeboat-crewmembers with those a MCD rough-sea conditions. Methods Lifeboat-crewmembers were scheduled compression-only CPR on resuscitation-mannequin two sets five 6-min epochs lifeboat at sea in...
Introduction: Crewmembers of the “Royal Netherlands Sea Rescue Institution” (KNRM) lifeboats must wear heavy survival suits with integrated lifejackets. This and challenging environment onboard (boat movements, limited space) might influence Basic Life Support (BLS) performance. The primary objective this study was to assess impact protective gear on single-rescuer BLS-quality. Material Methods: Sixty-five active KNRM crewmembers who had recently undergone a BLS-refresher course were...
The aim was to investigate the feasibility and optimal stimulation parameters for supramaximal of muscle recorded transcranial electrical motor evoked potentials (mTc-MEP).Forty-seven consecutive patients that underwent scoliosis surgery were included. First, assessed two settings (setting 1: pulse duration 0.075ms, interstimulus interval (ISI) 1.5ms; setting 2: 0.300ms, ISI 3ms). Thereafter, three mTc-MEP considered both settings; (1) elicitability, (2) amplitude, (3) if achieved with ≥ 20...