A5061984117- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Geometric and Algebraic Topology
- Tensor decomposition and applications
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Neurobiology and Insect Physiology Research
- Mathematics and Applications
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Congenital Heart Disease Studies
- Advanced Combinatorial Mathematics
- Advanced Neuroimaging Techniques and Applications
- Computational Physics and Python Applications
- Computational Geometry and Mesh Generation
- Homotopy and Cohomology in Algebraic Topology
- Diet and metabolism studies
- Algebraic structures and combinatorial models
- Advanced Operator Algebra Research
- stochastic dynamics and bifurcation
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Diaphragmatic Hernia Studies
- Cardiac and Coronary Surgery Techniques
National Institute of Technology, Kumamoto College
1986-2024
Tottori University
2012-2023
Hokkaido University
2000-2022
Navita (Brazil)
2022
Kyushu University
1989-2022
Waseda University
2002-2022
Dokkyo University
2022
Toyama University Hospital
2022
Yokohama City University Hospital
2022
Yokohama City University
2022
The sequence data (H. Okamoto et al., Hepatol. Res. 10:1-16, 1998) of a newly discovered single-stranded DNA virus, TT virus (TTV), showed that it did not have the terminal structure typical parvovirus. Elucidation complete genome was necessary to understand nature TTV. We obtained 1.0-kb amplified product from serum samples four TTV carriers by an inverted, nested long PCR targeted for nucleotides (nt) 3025 3739 and 1 216 clone sample TA278 compared with those registered in GenBank....
Intrahepatic lymphoid follicle (ILF) formation is one of the most characteristic and commonly observed histological features in patients with chronic hepatitis C. However, little known regarding whether follicles liver belong to functional tissues, where B cells are activated, differentiated, proliferated, or if lymphocytes merely infiltrated after recruitment from secondary organs. To ascertain this possibility, we examined expression markers for B-cell activation, differentiation,...
Of 21,791 pregnant women screened in Tottori Prefecture, Japan, 127 (0.58%) were positive for anti-hepatitis C virus (HCV) antibody and 84 (0.39%) HCV RNA. children followed up at least 6 months, 7 (8%) infected. All of them born to 26 mothers with a high load (HVL; >/=2.5x106 RNA copies/mL [27%]), compared 0 58 non-HVL (P<.001). Because all the infected vaginally delivered, infection rate among 16 delivered HVL was as 44%. The prevalence anti-NS4 an infectious significantly lower than that...
The pond snail Lymnaea stagnalis is capable of learning taste aversion and consolidating this into long-term memory (LTM) that called conditioned (CTA). Previous studies showed some molluscan insulin-related peptides (MIPs) were upregulated in snails exhibiting CTA. We thus hypothesized MIPs play an important role neurons underlying the CTA–LTM consolidation process. To examine hypothesis, we first observed distribution MIP II, a major peptide MIPs, receptor determined amounts their mRNAs...
Abstract Background Hepatocerebral mitochondrial DNA depletion syndrome (MTDPS) is a disease caused by defects in maintenance and leads to liver failure neurological complications during infancy. Liver transplantation (LT) remains controversial due poor outcomes associated with extrahepatic symptoms. The purposes of this study were clarify the current clinical molecular features hepatocerebral MTDPS evaluate LT patients Japan. Results We retrospectively assessed genetic findings, as well...
Abstract R. M. Kashaev conjectured that the asymptotic behavior of link invariant he introduced [Kashaev 951, which equals colored Jones polynomial evaluated at a root unity, determines hyperbolic volume any complement. We observe numerically for knots 63, 89 and 820 Whitehead link, polynomials are related to volumes Chern-Simons invariants propose complexification Kashaev's conjecture. Keywords: Volume conjectureKashaev's conjecturecolored polynomialChern-Simons invariantvolume
Abstract The pond snail Lymnaea stagnalis is an excellent model system in which to study the neuronal and molecular substrates of associative learning its consolidation into long‐term memory. Until now, presence cyclic AMP (cAMP)‐responsive element binding protein (CREB), believed be a necessary component process learned behavior that consolidated memory, has only been assumed neurons. We therefore cloned analyzed cDNA sequences homologues CREB1 CREB2 determined these mRNAs identifiable...
Abstract Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA) mediate various kinds of biological activities play an important role in cellular signal transduction. We analyzed serum phospholipids obtained from 16 multiple myeloma (MM) patients observed that LPA level was significantly higher MM (5.3±0.5 nmol/mL) than normal controls (1.7±0.3 nmol/mL). LPC also controls, it correlated with the concentration ( r =0.678, P <0.01). In patients, palmitic acid/linoleic ratios...
We investigated the safety and feasibility of sorafenib in patients with end-stage renal disease undergoing hemodialysis by examining influence pharmacokinetic parameters to their benefit also occurrence drug-related adverse events sorafenib.Ten metastatic cell carcinoma received sorafenib. Initial dose was 200 mg once daily, increased up maintenance twice daily. The study performed after a steady state reached daily six patients.Complete response occurred one patient, partial three, stable...
Mother-to-child transmission (MTCT) is the major pathway of hepatitis C virus (HCV) in children. However, its risk factors remain unsettled for introduction putative intervention. Pregnant women screened HCV and MTCT children born to antibody-positive mothers were prospectively studied Tottori, Japan. Among 41 856 women, 188 (0.45%) antibody-positive, whom 61% had detectable RNA. While 10 34 (29%) high viral load (HVL: ≥6.0 × 10(5) IU/mL) infected, none RNA-detectable but non-HVL infected (P...
We construct a vertex type state model in Turaev's sense for the multi-variable (non-reduced) Alexander polynomial.Our is colored version of 6-vertex free fermion model.To show correspondence our and polynomial, we introduce braid groups their Magnus representations.By using this model, new set axioms polynomial obtained.
Summary Insulin's action in the brain can directly alter cognitive functioning. We have recently shown that molluscan insulin-related peptides are up-regulated following a conditioned taste aversion (CTA) training procedure. In addition, when mammalian insulin is superfused over isolated Lymnaea central nervous system, it elicits long-term synaptic enhancement at monosynaptic connection between cerebral giant cell (CGC) and buccal 1 (B1) motor neuron. This thought to be neural correlate of...
Let G=GLn(C) be the group of linear transformations w-dimensional C-vector space FM. V* dual Vn and let Vi ':=Vf® (F?) Θ M (AT, M)-mixed tensor power Vn. We denote representation G on Vψ' by φ(>K The decomposition φ(* ) into a sum irreducible representations is given in [8] [13]. This result also indicates structure centralizer algebra Φ'(G). On other hand, Jimbo [5, 6] showed that natural quantum Uq(gl(n, C)) Q) isomorphic to Iwahori Hecke if n>N q^C generic. In present paper we introduce...
Abstract At present in Japan, only high‐risk infants born to chronic hepatitis B virus (HBV)‐infected mothers are given HBV vaccine. However, children can contract the from other HBV‐infected family members, including fathers. The aim of this study is substantial and unequivocal evidence father‐to‐child transmission infection using techniques homology analysis phylogenetic analysis. Thirteen members five families that included eight their respective fathers were enrolled study. Homology...
Few studies of zinc monotherapy for presymptomatic Wilson disease have focused on young children. We therefore evaluated long-term efficacy and safety such children established benchmarks maintenance therapy.We retrospectively prospectively examined under 10 years old with who received from time diagnosis at 12 participating pediatric centers in Japan.Twenty-four patients met entry criteria. Aspartate aminotransferase alanine decreased significantly beginning 1 month after initiation...
Abstract We have isolated and characterized the cDNAs for nitric oxide synthase (NOS) soluble guanylyl cyclase (sGC) from terrestrial slug Limax marginatus , examined presence distribution of their mRNAs in central nervous system using histological techniques a reverse transcription‐polymerase chain reaction method. Our results showed that both bursting nonbursting neurons procerebral lobes contain NOS sGC. further found oscillation frequency electrical activity increases with increasing...
Abstract Physicians often need to make prognostic judgments. In the present study, accuracy was explored of survival estimates for patients in Medical Intensive Care Unit (MICU). Estimates were made by physicians and nurses several times during each patient’s stay MICU compared those APACHE II scale, a widely used quantitative index critically ill patients. ROC curve calibration analyses performed assess these estimates. Results revealed that personnel fairly accurate discriminators who...