A5062222687- Trace Elements in Health
- RNA regulation and disease
- Metabolism and Genetic Disorders
- Heavy Metal Exposure and Toxicity
- Iron Metabolism and Disorders
- Aluminum toxicity and tolerance in plants and animals
- Amino Acid Enzymes and Metabolism
- Drug Transport and Resistance Mechanisms
- Infectious Encephalopathies and Encephalitis
- Neonatal Health and Biochemistry
- Diet and metabolism studies
- Folate and B Vitamins Research
- Infant Nutrition and Health
- Pharmacological Effects and Toxicity Studies
- Electrochemical Analysis and Applications
- Growth Hormone and Insulin-like Growth Factors
- Mitochondrial Function and Pathology
- RNA and protein synthesis mechanisms
- Breastfeeding Practices and Influences
- Migraine and Headache Studies
- Viral Infections and Immunology Research
- Alcoholism and Thiamine Deficiency
- Cancer, Hypoxia, and Metabolism
- Diabetes and associated disorders
- Biochemical and Molecular Research
Teikyo University
2015-2025
Japan Advanced Institute of Science and Technology
2024
Teikyo Heisei University
2012-2024
Japan Pediatric Society
2020
Juntendo University Nerima Hospital
2017
In-Q-Tel
2008
Tokushima University
2008
Ibaraki University
2003
Nagoya University
2001
Teikyo University Hospital
2000
Recent studies have demonstrated that gut microbiota development influences infants' health and subsequent host physiology. However, the factors shaping of remain poorly understood, mechanisms through which these affect metabolite profiles not been extensively investigated. Here we analyse 27 infants during first month life. We find three distinct clusters transition towards Bifidobacteriaceae-dominant microbiota. observe considerable differences in human milk oligosaccharide utilization...
Zinc concentrations in breast milk are considerably higher than those of the maternal serum, to meet infant's requirements for normal growth and development. Thus, effective mechanisms ensuring secretion large amounts zinc into operate mammary epithelial cells during lactation. ZnT2 was recently found play an essential role milk. Heterozygous mutations human (hZnT2), including H54R G87R, mothers result low (>75% reduction) milk, infants fed on develop transient neonatal deficiency. We...
Cox17p is essential for the assembly of functional cytochrome c oxidase (CCO) and delivery copper ions to mitochondrion insertion into enzyme in yeast. Although this small protein has already been cloned or purified from humans, mice, pigs, function mammalian system not yet elucidated. In vitro biochemical data indicate that binds sequence -KPCCAC-. mouse embryos homozygous COX17 disruption die between embryonic days E8.5 E10, they develop normally until E6.5. This phenotype strikingly...
In this review, we discuss genetic disorders involving altered coppermetabolism, particularly in relation to Menkes disease (MD), occipital horn syndrome (OHS), and Wilson's (WD). The responsible genes for MD WD are ATP7A ATP7B, respectively. Both proteins encoded by these transporting copper from the cytosol Golgi apparatus. However, pathology of is completely different that WD, is, characterized a deficiency while caused toxic excess copper. reason difference related particular cell types...
Background and objective Cyclic vomiting syndrome (CVS) is associated with migraine. This study aimed to evaluate the efficacy of sumatriptan in treating CVS. Methods Twelve patients were enrolled this trial. Sumatriptan was administered either subcutaneously [(age × 4 + 20)/100×3mg] or by nasal spray (NS; 20 mg). Response treatment classified as complete, effective, noneffective. Results Eleven patients, who presented 35 attacks, treated subcutaneous injection sumatriptan. The responsive 19...
The objective of the study was to investigate whether an infant formula supplemented with galacto-oligosaccharides (GOS; OM55N) able stimulate growth indigenous bifidobacteria and establish microbiota similar that breastfed infants. A randomised, double-blind, placebo-controlled trial performed using 35 healthy term infants (31-54 days age; 42±6 days) determine 0.3 g/dl GOS (OM55N) stimulated in infants’ guts. At onset 2 weeks after, faecal samples were examined for composition (bacterial...
RNA editing is a significant mechanism underlying genetic variation and protein molecule alteration; C-to-U editing, specifically, important in the regulation of mammalian diversity. The ability to define limit accesses enzymatic machinery avoid modification unintended targets key success editing. Identification core component apoB holoenzyme, APOBEC, investigation into new candidate genes encoding other elements complex could reveal further details regarding APOBEC-mediated mRNA Menkes...
Genomic DNA of 17 unrelated Japanese males with Menkes disease and 2 occipital horn syndrome were studied for mutations in the ATP7A gene. Using SSCP analysis direct sequencing exons 5′-upstream region gene amplified by PCR, we identified 16 disease, including 4 deletions, insertions, 6 nonsense mutations, missence splice-site mutations. All these those that affect function Of two syndrome, one had a mutation intron led to normal-size smaller-size transcripts. The amount transcripts his...
Wilson's disease (WD), an autosomal recessive copper transport disorder, usually presents with symptoms involving the liver or central nervous system. The is caused by a large number of mutations in ATP7B gene comprising 21 expressed exons. Some appear to be population specific, whereas others are found probands from variety different ethnic backgrounds. This paper results screening means direct sequencing all exons 39 Han and one Hui Chinese patients. Nineteen novel were revealed along nine...
Menkes disease (MD) is an X-linked recessive disorder caused by mutations in ATP7A. Patients with MD exhibit severe neurological and connective tissue disorders due to copper deficiency typically die before 3 years of age. Early treatment injections during the neonatal period, occurrence symptoms, can alleviate disturbances some degree. We investigated whether early symptoms help diagnosis MD. Abnormal hair growth, prolonged jaundice, feeding difficulties were observed period 20 69, 16 67,...
Prostaglandin F2 alpha (PGF2 alpha) stimulates proliferation of clonal osteoblastic MC3T3-E1 cells mainly via the stimulation phospholipase C. These constitutively produced and secreted insulin-like growth factor I (IGF-I). In addition, a neutralizing anti-IGF-I antibody completely abolished DNA synthesis stimulated by PGF2 in cells, suggesting that IGF-I indeed mediates effect. However, decreased expression mRNA secretion immunoreactive into medium, whereas progression activity conditioned...