A5103933415- Microbial Community Ecology and Physiology
- Genetic Mapping and Diversity in Plants and Animals
- Pancreatic function and diabetes
- Vestibular and auditory disorders
- Microplastics and Plastic Pollution
- Amphibian and Reptile Biology
- Genetic and phenotypic traits in livestock
- Marine and coastal ecosystems
- Hearing, Cochlea, Tinnitus, Genetics
- Marine and coastal plant biology
- Marine Biology and Ecology Research
- Adipose Tissue and Metabolism
- Animal Behavior and Reproduction
- Effects and risks of endocrine disrupting chemicals
- Wastewater Treatment and Nitrogen Removal
- Vibrio bacteria research studies
- Neuroscience and Neuropharmacology Research
- Drug Transport and Resistance Mechanisms
- Cardiomyopathy and Myosin Studies
- Methane Hydrates and Related Phenomena
- Cellular transport and secretion
- Animal Genetics and Reproduction
- Ion channel regulation and function
- Lipid metabolism and biosynthesis
- Diabetes and associated disorders
University of the Ryukyus
2009-2025
Sphere Institute
2012-2024
The University of Tokyo
2008-2024
International Research Center for Japanese Studies
2022
University of the Ryukyus University Hospital
2017-2021
Industrial Research Institute
2021
Nagoya University
2002-2012
University of Hyogo
2012
Osaka University
1970-2010
Kochi Medical School Hospital
2008-2010
The BIO14.6 hamster is a widely used model for autosomal recessive cardiomyopathy. These animals die prematurely from progressive myocardial necrosis and heart failure. primary genetic defect leading to the cardiomyopathy still unknown. Recently, linkage map localized locus on chromosome 9qa2.1-b1, excluding several candidate genes. We now demonstrate that results mutation in delta-sarcoglycan gene maps disease locus. This was completely coincident with backcross F2 pedigrees. constitutes...
実験動物育種の立場から糖尿病マウス系統の育成を目標とし, 既存の11系統の中から, 尿糖, 非絶食時血糖, 糖負荷試験による適応試験によって目標に沿う系統を探し, 更に重症の糖尿病マウスを得るための育種操作を行なった。KK系の糖尿病症状及びAy遺伝子の糖尿病効果を確認すると共に, 適応試験によりカスカベ及びニシキネズミグループに糖尿病傾向が広く認あられた。すなわちKSB系が雌において尿糖陽性, 両性においてKKと同じく高血糖, 糖処理能力劣弱を示し, またNC, NB, NBC, DDK系も糖処理能力劣弱を示した。次に, Ay遺伝子をKK系に導入することにより, Congenicstrain, KK-CAyを育成し, 発症率の高い, 激しい持続的尿糖と高血糖及び糖処理能力劣弱を呈する重症の糖尿病系統を得ることができた。一方, KK系とKSB系の交雑から重症化へのSele-ctionを行ない, F3世代において既に有意義な糖処理能力劣弱への選抜効果を認めた。しかし著しい繁殖力減退を伴ったため系統として固定するには至らなかった。
Depth‐related changes in whole‐community structure were evaluated a coastal marine sediment using molecular fingerprinting method, terminal restriction fragment length polymorphism (T‐RFLP) analysis, and chemotaxonomic technique (quinone profiling). Dendrograms derived from both T‐RFLP analysis quinone profiling indicated significant variation microbial community between the 0–2 cm layer deeper layers. This corresponded to dramatic change redox potential, acid‐volatile sulphide‐sulphur...
Syndecan-4 is a transmembrane heparan sulfate proteoglycan belonging to the syndecan family. Following intraperitoneal injection of lipopolysaccharide (LPS), syndecan-4-deficient mice exhibited high mortality compared with wild-type controls. Severe endotoxin shock was observed in deficient mice: systolic blood pressure and left ventricular fractional shortening were lower than controls 9 h after LPS injection. Although histological examinations revealed no apparent differences between two...
Abstract Objective. Effective rehabilitation for upper limb paralysis in patients with intracerebral hemorrhage mediated by hemiplegia has not yet been established. We evaluated the effectiveness of functional training using a wearable-type exoskeleton driven bio-electric signals motor function scores and tractography corticospinal tract (CST). Approach. Nine putamen seven thalamus were trained hybrid assistive (HAL) wearable exoskeleton. Among participants, 12 individuals severe hemiplegic,...
The beige rat is an animal model of the Chédiak-Higashi syndrome. Since mast cells can be easily purified from peritoneal cavity rats, we investigated function with giant granules by using quantitative methods. Beige and normal were sensitized anti-dinitrophenol (DNP) IgE antibodies stimulated DNP conjugated human serum albumin. proportion histamine released to total was significantly greater in than cells. supernormal release observed after treatment 12-O-tetradecanoylphorbol 13-acetate,...
Zostera marina (eelgrass) is classified as one of the marine angiosperms and widely distributed throughout much Northern Hemisphere. The present study investigated microbial community structure diversity Z. growing in Futtsu bathing water, Chiba prefecture, Japan. purpose this was to provide new insight into colonization eelgrass leaves by communities based on leaf age compare these root-rhizome , surrounding microenvironments (suspended particles, seawater, sediment). composition each...
Seagrass meadows produce organic carbon and deposit it on the seabed through decaying process. Microbial activity is closely related to process of eelgrass death collapse. We investigated microbial community structure during decomposition by using a microcosm containing raw seawater excised leaves collected from Zostera marina bed in Futtsu, Chiba Prefecture, Japan. The fast-growing microbes (i.e., Alphaproteobacteria, Gammaproteobacteria, Flavobacteriia) rapidly adhered leaf surface...
Journal Article Effect of W and Wυ alleles on production tissue mast cells in mice Get access SOEI GO, GO postdoctoral fellow Institute for Cancer Research, Medical School, Osaka UniversityKita-ku, 530 Japan Search other works by this author on: Oxford Academic PubMed Google Scholar YUKIHIKO KITAMURA, KITAMURA associate professor MASAHIKO NISHIMURA lecturer Laboratory Animal Center, Wakayama CollegeWakayama City, 640 Heredity, Volume 71, Issue 1, January 1980, Pages 41–44,...
Onboard microcosm experiments were conducted to assess how bacterial growth pattern and community structure changed by the addition of labile organic compound during KH-14-2 cruise R/V Hakuho Maru (Atmosphere Ocean Research Institute, University Tokyo JAMSTEC) in May-June 2014. Seawater samples collected from three diversified oceanic environments, Kuroshio Current, North Pacific Sub-polar Gyre (SPG), Sub-tropical (STG) western Ocean, filtered, supplemented with glucose, incubated at 23 ± 1...
Conclusion. Since many water channels and pumps, such as aquaporin (AQP) 1–4, AQP6–9, vasopressin type 2 receptor (V2-R), Na+-K+-Cl– cotransporter (NKCC) 1, NKCC2 were expressed in the rat endolymphatic sac, it should play an important role physiological function of acid-based metabolism balance fluid homeostasis. Objective: To evaluate expression immunolocalization AQP1–9, V2-R, NKCC1, sac. Materials methods. Wistar rats used. Expression mRNA sac was investigated using reverse...
A specific RIA for somatostatin (SRIF) was used to determine the SRIF content of pancreas and hypothalamus in spontaneously diabetic C57BL/KsJ dbdb C57BL/6J dbob mice. In addition, SRIF- glucagon-containing cells were examined pancreatic islets with an immunohistochemical technique. mice, immunoassayable increased, as number or cells. obob also but no increase noted The hypothalamic either strain not different from that controls. These results regarding accord some all previous reports....
In the SMXA recombinant inbred (RI) strains, we measured body weight, blood insulin and lipid (triglyceride, total cholesterol phospholipid) levels in each strain. five traits, mean values of substrains varied remarkably showed a continuous spectrum distribution, suggesting control by multiple genes at distinct loci for trait. We also screened quantitative trait (QTLs) involved traits. Suggestive QTLs weight (Chromosomes 1 6), 1, 3, 10 17), triglyceride 4 11) phospholipid (Chromosome 18)...