A5091870067- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Bacteriophages and microbial interactions
- Bacterial Identification and Susceptibility Testing
- Genomics and Phylogenetic Studies
- Viral gastroenteritis research and epidemiology
- Endoplasmic Reticulum Stress and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral Infections and Immunology Research
- Zeolite Catalysis and Synthesis
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Infections and bacterial resistance
- Cancer, Hypoxia, and Metabolism
- Mycobacterium research and diagnosis
- Plant Pathogenic Bacteria Studies
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Antibiotic Resistance in Bacteria
- Animal Virus Infections Studies
- Antimicrobial Resistance in Staphylococcus
National Health Research Institutes
2016-2025
Chinese Academy of Sciences
2025
University of Science and Technology of China
2025
Shanghai Ninth People's Hospital
2019-2025
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
Fudan University
2025
Zhejiang Provincial People's Hospital
2024
Xiamen University
2024
Beijing University of Posts and Telecommunications
2024
Abstract Ferroelectric (FE) synapses are promising for neuromorphic computing toward enhanced artificial intelligence systems. Nonetheless, there is a significant gap in understanding how to effectively tailor self‐polarization and its implications on synaptic device performance. Here, an approach using interfacial element accumulation reported the states of BaTiO 3 (BTO)/La 0.67 Sr 0.33 MnO (LSMO) FE heterostructure into single domain state. This configuration results demonstrated gradient...
Naturally occurring mutants with a deletion in the pre-S2 region of large surface protein (ΔS2-LHBs) are prevalent serum and livers patients chronic hepatitis B virus (HBV) infection associated cirrhosis. The ΔS2-LHBs is retained endoplasmic reticulum (ER) may induce ER stress. One interesting observation consistently clustered distribution hepatocytes expressing ΔS2-LHBs. In this study, complementary DNA microarray analysis identified cyclin A several groups genes as being significantly...
Ground glass hepatocytes (GGH) in chronic hepatitis B virus (HBV) infection harbor HBV pre-S deletion mutants endoplasmic reticulum (ER) and exhibit complex biologic features such as ER stress, DNA damage, growth advantage. The presence of serum has been shown to predict the development hepatocellular carcinoma (HCC) carriers. GGHs hence represent a potentially preneoplastic lesion. Whether specific factor is overexpressed activated remains be clarified. In this study, factor(s) up-regulated...
Ground glass hepatocytes (GGHs) harboring hepatitis B virus (HBV) pre-S mutants have been recognized as precursor lesions of hepatocellular carcinoma (HCC). Previously, we observed the activation mammalian target rapamycin (mTOR) in GGHs and HCCs, together with a decreased expression HBV surface antigen (HBsAg) HCC tissues. It is, therefore, hypothesized that mTOR during tumorigenesis may potentially down-regulate HBsAg expression. In this study, verified an inverse relationship between...
Abstract BACKGROUND: The recurrence of hepatocellular carcinoma (HCC) after hepatectomy is a serious event. It has been demonstrated that different ground‐glass hepatocyte (GGH) patterns harbor specific hepatitis B virus (HBV) pre‐S deletion mutants and represent preneoplastic lesions in chronic HBV infection. In the current study, authors investigated whether GGH pattern nontumorous liver tissues was associated with HBV‐related HCC surgery. METHODS: Clinicopathologic data from 82 patients...
Hepatitis B virus (HBV) pre-S2 mutant can induce hepatocellular carcinoma (HCC) via the induction of endoplasmic reticulum stress to activate mammalian target rapamycin (MTOR) signaling. The association metabolic syndrome with HBV-related HCC raises possibility that mutant-induced MTOR activation may drive development disorders promote tumorigenesis in chronic HBV infection. To address this issue, glucose metabolism and gene expression profiles were analyzed transgenic mice livers harboring...
Abstract Chronic hepatitis B virus (HBV) infection is a major risk factor for the development of hepatocellular carcinoma (HCC), leading cause cancer mortality worldwide. Hepatitis X protein (HBx) and pre-S2 mutant have been proposed as two most important HBV oncoproteins that play key roles in HCC pathogenesis. Curcumin botanical constituent displaying potent anti-inflammatory anti-cancer properties without toxic side effects. Phytosomal formulation curcumin has shown to exhibit enhanced...
ABSTRACT The development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) has been found to be associated with disturbed lipid metabolism. To elucidate the role metabolism in HBV tumorigenesis, we investigated dynamic pattern pre-S2 mutant-induced tumorigenesis. Lipid and gene expression profiles were analyzed an vitro culture system transgenic mouse livers harboring mutant. mutant showed a biphasic accumulation, starting from mild fatty change early (1 month) livers, which...
Rapid detection of drug resistance in Mycobacterium tuberculosis (Mtb) from clinical samples facilitates the timely provision optimal treatment regimens for (TB) patients. In November, 2023, WHO released its second catalogue resistance-conferring mutations Mtb. Utilizing this information, we developed a single 17-plex PCR assay covering 16 key genes and modified thermo-protection buffer to amplify 30 kbp DNA directly sputum nanopore sequencing. We implemented our protocol using rapid...
Background: Cell therapy demonstrates promising potential as a substitute therapeutic approach for liver cirrhosis. We have developed strategy to effectively expand murine and human hepatocyte-derived progenitor-like cells (HepLPCs) in vitro. The primary objective of the present study was apply HepLPCs treatment cirrhosis elucidate underlying mechanisms responsible their efficacy. Methods: effects allogeneic or xenogeneic HepLPC transplantation were investigated rat model Liver tissues...
Lithium plating on the surface of anode electrodes poses significant hazards to cell performance. deposition not only leads thickness growth and swelling but also promotes formation lithium dendrites, which can penetrate cell's separator. However, changes serve as an accurate indicator for detecting in cells. This study aims precisely monitor state by tracking changes. An experimental situ with a resolution 0.1 μm is developed detect without requiring disassembly during normal operation. A...
Recent advances in whole-genome sequencing (WGS) have increased the accessibility of this tool, offering substantial potential for pathogen surveillance, outbreak response, and diagnostics. However, routine clinical adoption WGS is hindered by factors such as high costs, technical complexity, requirement bioinformatics expertise data analysis. To address these challenges, we propose RapidONT, a workflow designed cost-effective accessible WGS-based RapidONT employs mechanical shearing–based...
The emergence of Rocahepevirus ratti genotype 1 (rat hepatitis E virus; rat HEV) in humans presents an unprecedented threat; however, the risk HEV transmission to is not well understood. Here, we report "Distinguishing Antibody Response Elicitation (DARE)" method, which distinguishes exposure HEV. We use four study sets from China for large-scale population analysis: set (hospital visit) and 3 (ALT abnormality) Yunnan province, a biodiversity hotspot, 2 (received physical examination) 4...
Although many studies on the risk factors and their carcinogenesis in adult hepatocellular carcinoma (HCC) have been reported, they remain poorly understood childhood HCC. A retrospective study of 42 HCC cases Asian children was conducted. Hepatitis B virus (HBV)-DNA tissues detected 36 (86%) tested, while no hepatitis C (HCV)-RNA detectable any HCCs. Twenty (56%) were accompanied by cirrhosis. Surprisingly, very high prevalence HBV pre-S deletion mutant recognized 27 30 (90%) HCCs examined....
The Oxford Nanopore MinION is an affordable and portable DNA sequencer that can produce very long reads (tens of kilobase pairs), which enable de novo bacterial genome assembly. Although many algorithms tools have been developed for base calling, read mapping, assembly, polishing, automated pipeline not available one-stop analysis circular reconstruction. In this paper, we present the CCBGpipe completing genomes. Raw current signals are demultiplexed called to generate sequencing data....
Multilocus sequence typing (MLST) is one of the most commonly used methods for studying microbial lineage worldwide. However, traditional MLST process using Sanger sequencing time-consuming and expensive. We have designed a workflow that simultaneously sequenced seven full-length housekeeping genes 96 meticillin-resistant Staphylococcus aureus isolates with dual-barcode multiplexing just single flow cell an Oxford Nanopore Technologies MinION system, then we performed bioinformatic analysis...
Abstract Corneal neovascularization (CNV) is one of the common blinding factors worldwide, leading to reduced vision or even blindness. However, current treatments such as surgical intervention and anti-VEGF agent therapy still have some shortcomings evoke adverse effects. Recently, SU6668, an inhibitor targeting angiogenic tyrosine kinases, has demonstrated growth inhibition neovascularization. But hydrophobicity low ocular bioavailability limit its application in cornea. Hereby, we...
Abstract Background Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S 1 and -S 2 mutant large HBV surface antigen (LHBS), in which the regions LHBS gene are partially deleted, highly associated with HBV-related HCC. Methods region two hundred one HBV-positive serum samples was PCR-amplified sequenced. A oligonucleotide chip developed to efficiently detect deletions chronic carriers. Twenty from carriers were analyzed using...
Chronic hepatitis B virus (HBV) infection is the major cause of hepatocellular carcinoma (HCC). The pre-S 2 mutant large HBV surface antigen (LHBS) in type II ground glass hepatocytes (GGHs) has been recognized as an emerging viral oncoprotein; it directly interacts with c-Jun activation domain-binding protein 1 (JAB1) and subsequently causes hyperphosphorylation tumor-suppressor retinoblastoma and, consequently, leads to disturbed cell cycle progression. interaction LHBS JAB1 could provide...
Objective: Enterovirus 71-induced brainstem encephalitis with pulmonary edema and/or neurogenic shock (stage 3B) is associated rapid mortality in children. In a small pilot study, we found that milrinone reduced early compared historical controls. This prospective, randomized control trial was designed to provide more definitive evidence of the ability reduce 1-week stage 3B enterovirus 71 infections. Design: Prospective, unicenter, open-label, randomized, controlled study. Setting:...