A5077373479- Chronic Obstructive Pulmonary Disease (COPD) Research
- Corneal Surgery and Treatments
- Sepsis Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Ferroptosis and cancer prognosis
- Iron Metabolism and Disorders
- Sulfur Compounds in Biology
- Ocular Surface and Contact Lens
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and Mental Health
- Respiratory Support and Mechanisms
- COVID-19 and healthcare impacts
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Video Surveillance and Tracking Methods
- Advanced Nanomaterials in Catalysis
- Hydrogen's biological and therapeutic effects
- Human Motion and Animation
- Autophagy in Disease and Therapy
- Visual Attention and Saliency Detection
- Indoor Air Quality and Microbial Exposure
- Nanoparticle-Based Drug Delivery
- Olfactory and Sensory Function Studies
- Medical and Biological Ozone Research
- Heme Oxygenase-1 and Carbon Monoxide
Zhongshan Hospital
2020-2025
Fudan University
2020-2025
Xiamen University
2023-2025
Eye Center
2025
The First Affiliated Hospital, Sun Yat-sen University
2020-2023
Sun Yat-sen University
2020-2023
Beijing Forestry University
2023
Zhejiang University of Technology
2022-2023
Baystate Medical Center
2020
University of Massachusetts Chan Medical School
2020
Abstract Importance Heart injury can be easily induced by viral infection such as adenovirus and enterovirus. However, whether coronavirus disease 2019 (COVID-19) causes heart hereby impacts mortality has not yet been fully evaluated. Objective To explore occurs in COVID-19 on admission aggravates later. Design, Setting, Participants A single-center retrospective cohort study including 188 patients admitted from December 25, to January 27, 2020 Wuhan Jinyintan Hospital, China; follow up was...
Triple-negative breast cancer (TNBC) is a subtype of with poor outcome and lacks approved targeted therapy. Overexpression epidermal growth factor receptor (EGFR) found in more than 50% TNBC suggested as driving force progression TNBC; however, targeting EGFR using antibodies to prevent its dimerization activation shows no significant benefits for patients. Here we report that monomer may activate signal transducer activator transcription-3 (STAT3) the absence transmembrane protein TMEM25,...
To determine the prevalence of dry eye syndrome, analyze relationship between symptoms and signs, identify associated risk factors for syndrome in an elderly Tibetan population at high altitude.A population-based survey was conducted from October 2006 to December 2006. A stratified, clustered, random sampling procedure used select 2632 native people >or=40 years age. Symptoms were assessed by using a 6-item validated questionnaire. Dry diagnosed those subjects having 1 or more often all...
Dear editor, In late December 2019, a novel contagious pneumonia named coronavirus disease 2019 (COVID-19) has broken out in Wuhan, China.1 On January 30, 2020, World Health Organization (WHO) declared COVID-19 as Public Emergency of International Concern. March 11, WHO characterized pandemic.2, 3 Much research work been done for hospitalized patients, mainly clinical characteristics.4 However, few studies have reported the post-discharge follow-up status, especially mental health status...
Since the theory of free radical-induced aging was proposed in 1956, it has been constantly proven that reactive oxygen species (ROS) produced by oxidative stress play a vital role occurrence and progression eye diseases. However, inherent limitations traditional drug therapy hindered development ophthalmic disease treatment. In recent years, great achievements have made research nanomedicine, which promotes rapid safe theranostics ophthalmology. this review, we focus on applications...
A bstract Purpose: To describe the prevalence and to identify associated risk factors for pterygium in a Tibetan population at high altitude Zeku County, China. Methods: prospective population‐based survey was conducted from October December 2006. stratified, clustered, randomized sampling procedure used select 2632 people aged 40 years older. Pterygium diagnosed graded clinically as grade 1 (transparent), 2 (intermediate) 3 (opaque). Risks with were evaluated logistic regression models....
Abstract Corneal neovascularization (CNV) is one of the common blinding factors worldwide, leading to reduced vision or even blindness. However, current treatments such as surgical intervention and anti-VEGF agent therapy still have some shortcomings evoke adverse effects. Recently, SU6668, an inhibitor targeting angiogenic tyrosine kinases, has demonstrated growth inhibition neovascularization. But hydrophobicity low ocular bioavailability limit its application in cornea. Hereby, we...
ABSTRACT Corneal neovascularization (CNV) is a debilitating ocular surface disease that severely compromises visual function and carries significant risk of vision loss. Despite its clinical impact, the development effective safe pharmacological treatments for CNV remains an unmet medical need. The pathogenesis largely driven by inflammation excessive oxidative stress. In this study, we introduce novel nanotherapeutic strategy utilizing vanadium carbide quantum dots (V 2 C QDs) with...
<title>Abstract</title> Sonodynamic therapy (SDT) has demonstrated significant clinical potential in malignant tumor treatment due to its deep tissue penetration and spatiotemporal controllability. Its core mechanism relies on ultrasound-activated sonosensitizers generate reactive oxygen species (ROS), thereby inducing cell apoptosis. However, conventional face limitations ROS yield tumor-targeting efficiency. In this study, we innovatively designed a multifunctional metal-organic nanosheet...
There were few studies on the mortality of severe community-acquired pneumonia (SCAP) in elderly people. Early prediction 28-day hospitalized patients will help clinical management (age ≥65 years) with SCAP, but a model that is reliable and valid still lacking.The 292 SCAP met criteria defined by American Thoracic Society from 33 hospitals China. Clinical parameters analyzed use univariable multivariable logistic regression analysis. A nomogram to predict was constructed evaluated using area...
Eosinophilic inflammation is related to the progression and outcomes of acute exacerbation chronic obstructive pulmonary disease (AECOPD). Till now, few studies have focused on low EOS in AECOPD.To reveal clinical characteristics, therapeutic responses prognosis patients hospitalized AECOPD with EOS.The electronic database Zhongshan Hospital, Fudan University was used. Cohort 1 included 608 AECOPD. Study population 2 consisted 166 admission at least twice. Impact NIMV treatment, length...
Background: Inpatients with coronavirus disease 2019 (COVID-19) have been well depicted in clinical characteristics. However, few studies reported post-discharge conditions, especially mental health status, for survivors following COVID-19. In this study, we aimed to first report status COVID-19 and explore relevant influence factors. Methods: descriptive case series, enrolled a population of 370 Wuhan Jinyintan Hospital, China. Survivors were discharged during Jan 4 Feb 12, 2020. Telephone...
Smoke-induced acute lung injury (ALI) is a grievous disease with high mortality. Despite advances in medical intervention, no drug has yet been approved by the Food and Drug Administration (FDA) for ALI. In this study, we reported that pretreatment high-molecular-weight hyaluronan (1600 kDa, HA1600) alleviated pulmonary inflammation mice exposed to smoke also upregulated long non-coding RNA (lncRNA) metastasis-associated adenocarcinoma transcript 1 (MALAT1), as well suppressor of cytokine...
Cigarette smoke (CS)-induced accelerated senescence and insufficient autophagy has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). Peroxiredoxin (PRDX) 6 is a protein with prevalent antioxidant capacity. Previous studies indicate that PRDX6 could activate alleviate other diseases. The present study investigated whether PRDX6-regulated was involved regulation CS extract (CSE)-induced BEAS-2B cell via knockdown expression. Furthermore, evaluated mRNA levels...
Airflow obstruction is a critical element of chronic airway diseases. This study aimed to evaluate the impact preoperative airflow on prognosis patients following surgery for esophageal carcinoma.A total 821 cancer were included and classified into two groups based whether or not they had obstruction. was defined as forced expiration volume in first second (FEV1)/forced vital capacity (FVC) ratio below lower limit normal (LLN). A retrospective analysis survival with carcinoma undergoing...