A5031377508- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Atrial Fibrillation Management and Outcomes
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiovascular and Diving-Related Complications
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Arrhythmias and Treatments
- Neurological and metabolic disorders
- Cardiovascular Health and Disease Prevention
- Cardiac tumors and thrombi
- Peripheral Artery Disease Management
- Moyamoya disease diagnosis and treatment
- Neurological Disorders and Treatments
- Thyroid Disorders and Treatments
- Congenital Heart Disease Studies
- Neurological Complications and Syndromes
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Ophthalmology and Eye Disorders
- Aortic Thrombus and Embolism
- Chronic Kidney Disease and Diabetes
- Coronary Artery Anomalies
NTT Medical Center
2018-2024
Nippon Medical School
2011-2024
Nippon Medical School Hospital
2012-2024
Higashi Nippon International University
2021
University of Pennsylvania
2018
Neurological Surgery
2017
Kasumigaura Medical Center
2006
Tokyo Medical University
2006
Tokyo Metropolitan Geriatric Hospital
2003-2005
Kanazawa Medical University
2004
<h3>Importance</h3> Whether intravenous thrombolysis is needed in combination with mechanical thrombectomy patients acute large vessel occlusion stroke unclear. <h3>Objective</h3> To examine whether alone noninferior to combined plus for favorable poststroke outcome. <h3>Design, Setting, and Participants</h3> Investigator-initiated, multicenter, randomized, open-label, noninferiority clinical trial 204 ischemic due enrolled at 23 hospital networks Japan from January 1, 2017, July 31, 2019,...
Rationale Bridging therapy with endovascular (EVT) and intravenous thrombolysis (IVT) has been reported to improve outcomes for acute stroke patients large-vessel occlusion in the anterior circulation. While IVT may increase reperfusion rate, risk of hemorrhagic complications increases. Whether EVT without (direct EVT) is equally effective as bridging remains unclear. Aim This randomized study versus tissue plasminogen activator ICA M1 aims clarify efficacy safety direct compared therapy....
<b><i>Background:</i></b> Epidemiological and clinical trials have shown that n-3 polyunsaturated fatty acids (PUFAs) reduce the incidence of coronary heart disease or stroke. However, association between PUFAs acute-phase stroke has not yet been thoroughly studied. We investigated impact serum on early neurological deterioration (END) in patients with acute ischemic <b><i>Methods:</i></b> In this retrospective study, we enrolled 281 Japanese...
Background and purpose Anticoagulant treatment with a vitamin K antagonist ( VKA ) has been reported to reduce stroke severity when patients atrial fibrillation (AF) suffer acute ischaemic AIS ). Direct oral anticoagulant DOAC therapy also the potential initial of . However, effect on is not well known. The aim present study was investigate s in non‐valvular AF. Methods From March 2011 July 2016, consecutive having AF were recruited. effects prior assessed by multivariate logistic regression...
Background The aims of the present study were to investigate relationships between prior direct oral anticoagulant ( DOAC ) therapy and infarct volume site arterial occlusion in patients with acute ischemic stroke non-valvular atrial fibrillation. Methods Results From March 2011 through November 2016, consecutive middle cerebral artery territory fibrillation recruited. was assessed semi-automatically using initial diffusion-weighted imaging, evaluated on magnetic resonance angiography....
Heat-shock proteins (hsp) are chaperon molecules important in protein folding and assembly. Furthermore, they may have functions immunoregulatory processes, like T-cell stimulation antigen presentation, which not yet fully understood. It has been shown that several hsp of various species family derivations modulate macrophage immunity by directly increasing cytokine production. In the present study we showed 60,000 MW Legionella pneumophila (Lp-hsp 60) increased cellular steady-state levels...
We investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke.The subjects were 105 consecutive without diabetes who hospitalized due to non-cardioembolic stroke. The was evaluated by homeostasis model assessment (HOMA-IR). degrees periventricular hyperintensity (PVH) deep subcortical (DSWMH) brain MRI. HOMA-IR values >or=2.5 indicative resistance.The presence PVH DSWMH 86.7 83.8%,...
Infection of macrophages with Legionella pneumophila induces formation interleukin 1 beta (IL-1 beta), but the molecular basis this is not understood. Binding bacteria to macrophage surfaces first step in an infection process. Therefore, we examined whether was sufficient increase cellular level mRNAs for IL-1 and other cytokines. To assess effect binding L. on steady-state levels cytokine mRNAs, cultures thioglycolate-elicited from pneumophila-susceptible A/J mice were treated cytochalasin...
Limb-shaking associated with steno-occlusion of the internal carotid artery (ICA) was first reported by Miller Fisher1 in 1962, and is characterized brief, jerky, coarse, involuntary movements involving an arm or leg. TIA under-recognized manifestation intracranial extracranial occlusion severe stenosis. Although hemodynamic compromise has been suggested to be shaking movements, pathogenic nature this symptom remains unclear. Neurophysiologic evaluation movement disorder would useful, but...
Background: Antithrombotic therapy (AT) should generally be avoided within 24 hours after recombinant tissue-plasminogen activator (rt-PA) treatment but considered in patients with large-artery atherosclerosis (LAA) who undergo concomitant emergent endovascular (EVT). The aim of the present study was to assess safety AT rt-PA hyperacute ischemic stroke due LAA received EVT. Methods: From January 2013 through July 2019, consecutive acute cerebrovascular disease were admitted 6 from symptom...
A 35-year-old man presented with simultaneous occurrence of subarachnoid hemorrhage (SAH) and cerebral infarction (CI) caused by anterior artery (ACA) dissection. He complained sudden onset left frontal headache his symptoms progressed to consciousness disturbance right hemiparesis. Computed tomography magnetic resonance imaging demonstrated SAH localized in the interhemispheric fissure CI territory ACA. Right carotid angiography a long double lumen sign at A2 A4 segment ACA, leading...
We herein report the case of a 75-year-old woman with paradoxical cerebral air embolism (CAE). She developed bilateral visual disturbance at time needle puncture during computed tomography (CT)-guided percutaneous lung biopsy in face down position. The density within descending aorta on chest CT suggested presence embolism. Brain MRI demonstrated increased signal intensity occipital lobes diffusion-weighted images. Usually, CAE occurs predominantly right hemisphere for anatomical reasons....
Intra-arterial transplantation of bone marrow mononuclear cells (BMMCs) effectively improves neuronal function and limits the infarct size. We monitored fate BMMCs labeled with super paramagnetic iron oxide (SPIO) until 7 days after using high-field magnetic resonance imaging (MRI).Male Sprague-Dawley rats were subjected to 90-minute focal ischemia intraluminal suture technique followed by 1 × 10(7) or vehicle only via ipsilateral carotid artery immediately reperfusion. Autologous SPIO...