A5041865783- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Nutrition and Health in Aging
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Alzheimer's disease research and treatments
- Health, Medicine and Society
- Health Systems, Economic Evaluations, Quality of Life
- Aging, Elder Care, and Social Issues
- COVID-19 Clinical Research Studies
- Healthcare Systems and Practices
- Chronic Disease Management Strategies
- Geriatric Care and Nursing Homes
- Neurological Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Palliative Care and End-of-Life Issues
- Cerebrovascular and genetic disorders
- Neurological Disease Mechanisms and Treatments
- COVID-19 and healthcare impacts
- Functional Brain Connectivity Studies
- Telomeres, Telomerase, and Senescence
- Advanced MRI Techniques and Applications
- Healthcare Decision-Making and Restraints
- Pneumonia and Respiratory Infections
University of Geneva
2015-2024
University Hospital of Geneva
2014-2024
Hôpital Beau-Séjour
2012-2024
Geneva College
2001-2022
Institution Genevoise de Maintien à Domicile
2020-2021
Foundation for laboratory medicine
2020
Swiss Academy of Medical Sciences
2012
Sorbonne Université
2002-2008
Pitié-Salpêtrière Hospital
2004-2008
Harvard University
2008
Background: demented patients have been reported to be healthier than other old people of the same age. Objectives: assess comorbid conditions, functional and nutritional status in medically ill hospitalised with normal cognition or affected by dementia various causes severities, mild cognitive impairment (MCI). Design Setting: a prospective study was carried out, between January December 2004, Rehabilitation Geriatric Hospital (HOGER). Methods: activities daily living (ADL), instrumental...
ObjectiveTo determine predictors of in-hospital mortality related to COVID-19 in older patients.DesignRetrospective cohort study.Setting and ParticipantsPatients aged 65 years hospitalized for a diagnosis COVID-19.MethodsData from hospital admission were collected the electronic medical records. Logistic regression Cox proportional hazard models used predict mortality, our primary outcome. Variables at categorized according following domains: demographics, clinical history, comorbidities,...
To explore whether arterial spin labeling (ASL) imaging in cognitively intact elderly individuals may be used to predict subsequent early neuropsychological decline.The local ethics committee approved this prospective study, and written informed consent was obtained from all participants. A total of 148 consecutive control subjects were included, 75 whom had stable cognitive function (sCON) (mean age, 75.9 years ± 3.4 [standard deviation]; 43 female) 73 deteriorated (dCON) at 18-month...
Background Patients with dementia have poorer oral health and fewer teeth than their peers without cognitive impairment. Objective The hypothesis of this study is that the number natural chewing efficiency are associated functioning. Methods This cross‐sectional included 29 patients diagnosed aged 75 years or older 22 controls who were either cognitively normal ( n = 19) mild impairment 3). Neuropsychological, nutritional dental assessments performed. was evaluated a two‐colour mixing test....
Dementia is often considered a predictor of adverse hospitalization outcomes. However, the relative contributions dementia and other risk factors remain unclear.To assess, in prospective study, value for predicting outcomes, taking into account comorbidity, functional nutritional status 435 inpatients (age 85.3 +/- 6.7; 207 cognitively normal, 48 with mild cognitive impairment 180 demented) from acute rehabilitation geriatric hospital Geneva. Hospitalization outcomes (death hospital, length...
We investigated the use of Alzheimer's disease (AD) biomarkers in European Disease Consortium centers and assessed their perceived usefulness for etiologic diagnosis mild cognitive impairment (MCI). surveyed availability, frequency use, confidence diagnostic markers brain amyloidosis (amyloid positron emission tomography [PET], cerebrospinal fluid [CSF] Aβ42) neurodegeneration (medial temporal atrophy [MTA] on MR, fluorodeoxyglucose [FDG-PET], CSF tau). The most frequently used biomarker is...
Abstract Background Delirium prevalence increases with age and is associated poor outcomes. We aimed to investigate the risk factors for delirium in older patients hospitalized COVID-19, as well its association length of stay mortality. Method This was a retrospective study aged 65 years COVID-19. Data were collected from computerized medical records all had assessment at admission. Risk outcomes mentioned above studied by 2-group comparison, logistic regression, Cox proportional hazard...
Post-COVID condition is prevalent in 10-35% of cases outpatient settings, however a stratification the duration and severity symptoms still lacking, adding to complexity heterogeneity definition post-COVID its oucomes. In addition, potential impacts longer disease are not yet clear, along with which risk factors associated chronification beyond initial 12 weeks. this study, follow-up was conducted at 7 15 months after testing SARS-CoV-2 center Geneva University Hospitals. The defined as...
Persistent symptoms of SARS-CoV-2 are prevalent weeks to months following the infection. To date, it is difficult disentangle direct from indirect effects SARS-CoV-2, including lockdown, social, and economic factors.The study aims characterize prevalence symptoms, functional capacity, quality life at 12 in outpatient symptomatic individuals tested positive for compared negative.From 23 April 27 July 2021, Geneva University Hospitals were followed up after their test date.At months, out 1447...
Post-coronovirus disease (COVID) symptoms can persist several months after severe acute respiratory syndrome coronavirus 2 infection. Little is known, however, about the prevalence of post-COVID condition following infections from Omicron variants and how this varies according to vaccination status. This study evaluates functional impairment 12 weeks an infection by (BA.1 BA.2) compared with negative controls tested during same period.Outpatient individuals who positive or for COVID-19...
<b><i>Background:</i></b> The global number of centenarians is still strongly growing and information about the health healthcare needs this segment population needed. This study aimed to estimate prevalence frailty among included in a multinational investigate associated factors. <b><i>Methods:</i></b> 5-COOP cross-sectional survey including 1,253 5 countries (Japan, France, Switzerland, Denmark, Sweden). Data were collected using standardized...
The clinical progression of Alzheimer disease (AD) was studied in European subjects under treatment with AChE inhibitors (AChE-I) relation to geographical location over a 2-years period. One thousand three hundred and six from 11 countries were clustered into 3 regions (North, South, West) investigated biannual follow-up 2 years. Primary outcomes cognitive, functional behavioral measures. Caregiver burden, hospital admission nursing home also recorded. Participant cognitive function declined...
Background & aimsTo investigate the association of nutritional risk at admission with length hospital stay (LOS) and mortality in older patients COVID-19.MethodsRetrospective monocentric study an acute geriatric hospital. Data were collected after extensive review medical records was assessed according to Nutritional Risk Screening (NRS). Univariate multivariate (adjusted for age, sex comorbidity burden) Cox proportional-hazard linear regression models used above-mentioned outcomes.ResultsOf...