A5051568985- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Urban Transport and Accessibility
- Noise Effects and Management
- Air Quality Monitoring and Forecasting
- Health, Environment, Cognitive Aging
- Ethics in Clinical Research
- Chronic Disease Management Strategies
- Vehicle emissions and performance
- Health and Medical Studies
- Autopsy Techniques and Outcomes
- Data Quality and Management
- Childhood Cancer Survivors' Quality of Life
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenetic and Muscular Disorders Research
- Adolescent and Pediatric Healthcare
- Meta-analysis and systematic reviews
- Cutaneous Melanoma Detection and Management
- Clinical practice guidelines implementation
- Biomedical Ethics and Regulation
- Health Promotion and Cardiovascular Prevention
- Electronic Health Records Systems
- Medical Coding and Health Information
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2006-2024
Essen University Hospital
2008-2024
Medizinische Hochschule Hannover
2024
University of Duisburg-Essen
2008-2019
Agenzia Regionale Prevenzione e Ambiente della Regione Emilia-Romagna
2012
Zimmer Biomet (Germany)
2012
Land Use Regression (LUR) models have been used increasingly for modeling small-scale spatial variation in air pollution concentrations and estimating individual exposure participants of cohort studies. Within the ESCAPE project, PM(2.5), PM(2.5) absorbance, PM(10), PM(coarse) were measured 20 European study areas at sites per area. GIS-derived predictor variables (e.g., traffic intensity, population, land-use) evaluated to model annual average each The median explained variance (R(2)) was...
Studies investigating the link between long-term exposure to air pollution and incidence of diabetes are still scarce results inconsistent, possibly due different compositions particle mixture. We investigate effect traffic-specific total particulate matter (PM) road proximity on cumulative mellitus (mainly type 2) in a large German cohort. followed prospectively 3607 individuals without at baseline (2000–2003) from Heinz Nixdorf Recall Study Germany (mean follow-up time 5.1 years). Mean...
Recent studies have shown an association of short-term exposure to fine particulate matter (PM) with transient increases in blood pressure (BP), but it is unclear whether long-term has effect on arterial BP and hypertension.
<h3>Background</h3> In several studies, exposure to fine particulate matter (PM) has been associated with inflammation, inconsistent results. We used repeated measurements examine the association of long-term and ultrafine particle blood markers inflammation coagulation. <h3>Methods</h3> baseline (2000–2003) follow-up (2006–2008) data from Heinz Nixdorf Recall Study, a German population-based prospective cohort 4814 participants. A chemistry transport model was applied daily surface...
Abstract Background Nusinersen is an intrathecally administered antisense oligonucleotide (ASO) that improves motor function in patients with spinal muscular atrophy (SMA). In addition to efficacy, the safety of a therapy decisive factor for success treatment. For some ASOs, various organ toxicities have been described, such as thrombocytopenia, renal and liver impairment, or coagulation abnormalities. However, systematic data on laboratory parameters under treatment nusinersen are mainly...
The purpose of this study was: (1) to determine the combination risk factors which best predicts developing pressure ulcers among inpatients in an acute care university hospital; (2) appropriate weight for each factor; and (3) derive a concise easy-to-use assessment tool daily use by nursing staff.Efficient application preventive measures against requires identification patients at risk. Adequate tools are still needed because predictive value existing is sometimes unsatisfactory.Survey.A...
We analysed the effect of different body features on contact area, interface pressure and distribution three mattresses. Thirty-eight volunteers (age ranged from 17 to 73 years, 23 females) were asked lie mattresses in a random order: I, standard hospital foam mattresses; II, higher specification (Viscorelax Sure®); III, constant low devices (CareMedx®, AirSystems). Measurements performed supine position 90° left- right-sided position, respectively, using full-body mat (pressure mapping...
The 'Positron emission tomography-guided therapy of aggressive non-Hodgkin lymphomas' trial (PETAL; ClinicalTrials.gov NCT00554164) investigated whether treatment intensification after two cycles cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP; plus rituximab [R] for CD20-positive lymphomas) improved survival in lymphoma. A total 754 patients (87.5%) had a negative 108 (12.5%) positive interim PET scan. Interim PET-positive were randomly assigned to receive another 6...
With the optimization of medical care structures and rapid progress in development new therapeutic methods, an increase life expectancy is observed patients with neuromuscular diseases. This leads to expansion phenotypic spectrum, whereby or previously less relevant disease manifestations different organ systems gain more importance. The adolescents young adults diseases, therefore, requires increasingly close interdisciplinary collaboration within centers.How can transition process from...
Abstract Background Routine skin cancer screening (SCS) is covered by the German statutory health insurance (SHI) since 2008. The objective of this study was to compare direct healthcare costs between patients in whom detected routine SCS and not SCS. Methods A retrospective observational administrative claims data from a large SHI performed. Patients with diagnosis malignant melanoma (MM) or non-melanoma (NMSC) diagnosed 2014 2015 were included. Costs obtained for one year before after...
Abstract Objective Our study aimed to identify the superior predictor of mortality from International Classification Diseases 10 (ICD-10) codes among pediatric trauma patients in German hospital database (GHD), a nationwide comprising all hospitalizations country. Study design and setting Hospital admissions aged < 18 years with injury-related ICD-10 were selected. The maximum abbreviated injury scale (MAIS) severity score (ISS) calculated using ICD-AIS map provided by Association for...
Data quality significantly impacts the reliability and validity of empirical medical research. Specific measures can be used to check data during operation a research project like register. Furthermore these indicators allow an assessment independently from institution responsible for recording. A previously developed set 24 was compared with three projects, each representing specific view on topic. The structure confirmed, being able capture most projects' under headings plausibility,...
Abstract The impact of treatment in a non-pediatric department on mortality and outcomes children with traumatic brain injury (TBI) is unknown. This study aimed to quantify the treating (pediatric (PD) or adult (AD)) in-hospital case fatality functional short-term serious TBI who survived initial 12 hours after hospital admission. A Nationwide retrospective cohort was conducted from dataset that comprises all discharges German hospitals 2016 2021. Disease procedural codes were used retrieve...
Introduction: Decompressive craniectomy (DC) is a last tier to control refractory intracranial pressure elevation in children with severe traumatic brain injury (sTBI), but the optimal timing unknown. This study aimed describe association between of DC and in-hospital mortality sTBI Germany. Methods: A retrospective cohort German national hospital discharge database (2016-2022) was conducted for cases < 18 years. Children undergoing following were extracted. Time from admission calculated...