A5013051386- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Nonmelanoma Skin Cancer Studies
- AI in cancer detection
- Global Cancer Incidence and Screening
- Cutaneous Melanoma Detection and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Testicular diseases and treatments
- Childhood Cancer Survivors' Quality of Life
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Family Support in Illness
- Trauma and Emergency Care Studies
- Dialysis and Renal Disease Management
- Thyroid Cancer Diagnosis and Treatment
- Cancer and Skin Lesions
- Gastric Cancer Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Multiple and Secondary Primary Cancers
- Chronic Kidney Disease and Diabetes
- Cancer Diagnosis and Treatment
- Acute Kidney Injury Research
- BRCA gene mutations in cancer
- Ear and Head Tumors
- Genetic factors in colorectal cancer
Otto-von-Guericke University Magdeburg
2023-2025
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2016-2023
Essen University Hospital
2022-2023
University of Duisburg-Essen
2019-2021
Ruhrlandklinik
2021
West German Heart and Vascular Center Essen
2021
Klinik und Poliklinik für Urologie, Kinderurologie und Andrologie
2021
University Hospital Münster
2021
Charité - Universitätsmedizin Berlin
2021
Martin Luther University Halle-Wittenberg
2007-2016
There is little information on breast cancer (BC) survival in Ethiopia and other parts of sub-Saharan Africa. Our study estimated cumulative probabilities distant metastasis-free (MFS) patients at Addis Ababa (AA) University Radiotherapy Center, the only public oncologic institution Ethiopia. We analyzed 1,070 females with BC stage 1–3 seen 2005–2010. Patients underwent regular follow-up; estrogen receptor-positive -unknown received free endocrine treatment (an independent project funded by...
Background: The prevalence of non-end stage renal failure among adults in Germany is unknown.Accurate figures would enable us to estimate the overall need for kidney replacement therapies and unexploited potential disease prevention.Renal also an important cardiovascular risk factor.Until now, American have often been applied despite dissimilarities between two populations.Methods: We analyzed data on function from nationwide German Health Interview Examination Survey Adults, 2008-2011...
Abstract Background. Almost 500,000 women are newly diagnosed with cervical cancer (CC) every year, the majority from developing countries. There is little information on survival of these patients. Our primary objective was to evaluate consecutive CC patients presenting over 4 years at only radiotherapy center in Ethiopia. Methods. All September 2008 2012 who received and/or surgery were included (without brachytherapy). Vital status obtained through telephone contact or patient cards....
Zusammenfassung Im Projekt VersKiK sollen durch Verlinkung von Daten des Deutschen Kinderkrebsregisters mit Routinedaten gesetzlicher Krankenkassen die Art und Häufigkeit Spätfolgen medizinische Versorgung Langzeitüberlebenden nach Krebs im Kindes-oder Jugendalter untersucht werden. Das Deutsche Kinderkrebsregister definierte eine Grundgesamtheit ca. 50 000 Personen Krebserkrankung Kindes- oder der Diagnosejahre 1991–2021 (Überleben bis mindestens 1.1.2017). Die Identifizierung...
Mucoepidermoid carcinoma (MEC) is the most common of salivary glands. Here, we have used two large patient cohorts with MECs comprising 551 tumors to study clinical, histological, and molecular predictors survival. One cohort (n = 167), known CRCT1/3-MAML2 fusion status, was derived from Hamburg Reference Centre (HRC; graded AFIP Brandwein systems) other 384) population-based Cancer Registry North Rhine-Westphalia (LKR-NRW; system). The reliability both grading systems excellent 155)....
In contrast with breast cancers (BCs) in other parts of the world, most previous studies reported that majority BCs sub-Saharan Africa are estrogen-receptor (ER) negative. However, a recent study using US SEER database showed proportion ER-negative BC is comparable between US-born blacks and West-African born but substantially lower East African-born blacks, over 74% patients Ethiopians or Eritreans. this paper, we provide first report on Ethiopia, relation to progesterone-receptor (PgR)...
Background: Even though traumatic brain injury (TBI) is a major cause of morbidity and mortality in children around the globe, population-based nation-wide data to assess burden TBI scarce. Methods: Based on diagnosis related groups from hospital data, we extracted all TBI-related hospitalizations <18 years Germany between 2014 2018. We calculated crude, age-specific standardized incidence rates for hospitalizations, imaging, intracranial injury, neurosurgery, mortality. Results: Out...
Testicular cancer survival rates improved dramatically after cisplatin-based therapy was introduced in the 1970s. However, chemotherapy and radiation are potentially carcinogenic. The purpose of this study to estimate risk developing second primary cancers including associated with histologic type (seminoma non-seminoma) among testicular survivors Germany. We identified 16 990 1401 cases population-based registries East Germany (1961-1989 1996-2008) Saarland (a federal state West Germany;...
Estimating equations are recommended by clinical guidelines as the preferred method for assessment of glomerular filtration rate (GFR). The aim study was to compare population-based prevalence estimates decreased kidney function in Germany defined an estimated GFR (eGFR) <60 ml/min/1.73m2 using different equations. included 7001 participants German Health Interview and Examination Survey Adults 2008–2011 (DEGS1) whom Modification Diet Renal Disease equation (MDRD), revised Lund-Malmö (LM),...
In 2012 the age-standardized acute myocardial infarction (AMI) mortality rate was in federal state Saxony-Anhalt 67 deaths per 100.000 whereas Germany AMI-rate 47 100.000. The therefore 43 % above national average. Many factors may explain this above-average AMI rate: First, prevalence of cardiovascular risk (e.g. arterial hypertension, diabetes mellitus, smoking) is highest among all Federal States Germany. Second, structural health care for patients with potentially deficient insufficient...
This cohort study concerns the effect of skin cancer screening (SCS) on medical treatment intensity in patients with cancer.Routine data from persons aged 35 to 99 who were insured by AOK health insurance company used identify received a diagnosis malignant melanoma or non-melanocytic 2014 2015, either through without screening. These included studies. The routine contained no information tumor stages grading. Tumor-associated rates hospital admission, contact physicians outpatient practice,...
The planned nationwide implementation of mammography screening 2007 in Germany will increase the occurrence mammographically detected breast abnormalities. These abnormalities are normally evaluated by minimal invasive core biopsy. To minimize false positive and negative histological findings, quality assurance pathological evaluation biopsies is essential. Various guidelines for cancer diagnosis recommend applying B-classification histopathological categorization. However, to date there...
Stang A, Trocchi P, Ruschke K, Schmidt‐Pokrzywniak Holzhausen H‐J, Löning T, Buchmann J, Thomssen C, Lantzsch Hauptmann S, Böcker W & Kluttig A (2011) Histopathology 59 , 939–949 Factors influencing the agreement on histopathological assessments of breast biopsies among pathologists Aims: It has been recommended that histopathology results core are categorized according to B‐categorization scheme. We measured interobserver variability breast. Methods and results: Core were taken 765...
Abstract Background Routine skin cancer screening (SCS) is covered by the German statutory health insurance (SHI) since 2008. The objective of this study was to compare direct healthcare costs between patients in whom detected routine SCS and not SCS. Methods A retrospective observational administrative claims data from a large SHI performed. Patients with diagnosis malignant melanoma (MM) or non-melanoma (NMSC) diagnosed 2014 2015 were included. Costs obtained for one year before after...
Abstract Background and Objectives Until now mortality trends of melanoma nonmelanoma skin cancer (NMSC) in Germany have been studied only West Germany. We were interested comparing NMSC East before after the post‐communist transition. By analyses health care utilization data Germany, we explored potential reasons for differences between these regions. Methods analyzed (1980–2005). calculated sex‐specific age‐standardized rates using World Standard Population. age‐specific (20–39, 40–59,...
The shift from child-centered to adult-focused healthcare presents social and psychological challenges for adolescents young adults with chronic conditions, which can affect their participation in follow-up care. This study aims investigate the factors that influence patient-driven motivations adhering recommendations, while also exploring barriers supports impact transition process pediatric cancer survivors.
As high percentage of mammographic densities complicates the assessment imaging findings, density may influence histopathological evaluation core-biopsies breast. We measured on inter-observer variability findings breast biopsies. Histological slides 695 women who underwent core biopsies at University Halle between 2006 and 2008 were evaluated in a blinded fashion by two pathologists using five levels B-categorization scheme (B1-B5). To quantify density, we used computer-based threshold...
580 Background: There is little information on breast cancer (BC) patients (pts) receiving standardized treatment in Sub-Saharan Africa. This study evaluates pts presenting 2005-10 at the University Radiotherapy Center Addis Ababa, only institution country offering radiotherapy, systemic therapy and free endocrine (ET) during that time. Methods: All with histologically verified BC were included. Ethical approval was obtained. Axios/AstraZenaca provided ET. Therefore, majority of underwent...
Abstract Background & objectives The comparison of the incidence gonadal germ cell tumors among males and females can provide insights that cannot be gained by separately studying these tumors. Material methods Incidence data on male female were drawn from cancer registries North Rhine‐Westphalia, Germany, United States Surveillance, Epidemiology End Results program, for non‐Hispanic White persons only, years 2008–2016. We estimated age‐standardized age‐, histology‐specific rates....
Abstract Direct comparisons of the incidence and survival cutaneous vs mucocutaneous genital squamous cell carcinomas (SCCs) are lacking even though they may bring important insights. We aimed to compare rates SCCs head‐to‐head, using same source population, cancer registry methodology statistical methods in a population predominantly white Caucasian descent. Using data (2007‐2015) from population‐based North Rhine‐Westphalia, (population 18 million people), we estimated age‐specific...
The number of performed core biopsies the breast as diagnostic workup is increasing in many European countries. We measured intraobserver variability pathological assessment biopsies. Furthermore, we studied potential modifiers agreement between assessments. Two hundred and fifty-six were evaluated twice a blinded fashion by two pathologists. calculated observed chance-corrected (weighted) (kappa) using B-categorization scheme (B1: normal or not interpretable, B2: benign, B3: benign but...