A5080551664- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Digital Radiography and Breast Imaging
- Data-Driven Disease Surveillance
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Health and Medical Studies
- Data Quality and Management
- AI in cancer detection
- Breast Lesions and Carcinomas
- Ethics in Clinical Research
- Diabetes Treatment and Management
- Epigenetics and DNA Methylation
- Privacy-Preserving Technologies in Data
- Metabolism, Diabetes, and Cancer
- Cancer Genomics and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Colorectal Cancer Treatments and Studies
- Diabetes Management and Research
- Clinical practice guidelines implementation
- Privacy, Security, and Data Protection
- Health disparities and outcomes
- Cervical Cancer and HPV Research
University Hospital Münster
2018
St. Franziskus Hospital
2018
University of Münster
2018
National Cancer Registry
2018
Breast Center
2018
Landeszentrum Gesundheit Nordrhein-Westfalen
2018
Krebsregister Saarland
2012-2016
Krebsgesellschaft Nordrhein-Westfalen
2012-2015
Background: Cancer screening programs must meet high standards for quality and effectiveness, because many healthy persons need to be screened detect relatively few cases of cancer.In this study, we use the rate interval cancers as an important surrogate indicator evaluating German mammography program (MSP).Methods: All first-time participants in MSP federal state North Rhine-Westphalia over period 2005-2008 whose mammogram had been read negative were followed next 24 months potential...
Mammography screening programs (MSPs) aim to detect early-stage breast cancers in order decrease the incidence of advanced-stage and reduce cancer mortality. We analyzed time trends rates target population before after implementation MSP a region northwestern Germany.The Münster district started October 2005. A total 13,874 women with an incident invasive (BC) was identified by population-based epidemiological registry between 2000 2013 group 50-69 years. Multiple imputation methods were...
To determine the relationship between overall detection rates of ductal carcinoma in situ (DCIS) and specific low-, intermediate-, high-grade DCIS at start a digital mammography screening program.The study was approved by local ethics board did not require informed consent. Data were included first round examinations, performed 17 units women aged 50-69 years from 2005 to 2008. Grading provided cancer registry for 1018 cases. The association rate (cases per 100 screened) separate invasive...
Monitoring spatial disease risk (e.g. identifying areas) is of great relevance in public health research, especially cancer epidemiology. A common strategy uses case-control studies and estimates a relative function (sRRF) via kernel density estimation (KDE). This study was set up to evaluate the sRRF methods, comparing fixed with adaptive bandwidth-based KDE, how they were able detect 'risk areas' case data from population-based registry. The estimated within defined area, using locational...
Program sensitivity (PS), i.e., the ratio of screen-detected cancers divided by sum plus interval cancers, is a major outcome in population-based mammography screening programs (MSP). This study evaluated PS within digital MSP Germany focussing on impact age and histological subtype.Data 838,579 first-time participants aged 50-69 years who were screened 2005-2008 linked with cancer registry data from Germany's most populous state, North Rhine-Westphalia. Invasive breast ductal carcinomas...
Introduction Development of digital breast tomosynthesis (DBT) provides a technology that generates three-dimensional data sets, thus reducing the pitfalls overlapping tissue. Observational studies suggest combination two-dimensional (2D) mammography and DBT increases diagnostic accuracy. However, because duplicate exposure, this comes at cost an augmented radiation dose. This undesired adverse impact can be avoided by using synthesised 2D images reconstructed from (s2D). We designed...
The European Guidelines for breast cancer screening suggest that the impact of population-based mammography programmes (MSP) may be assessed using relative reduction in incidence advanced (ABC, is, stage UICC II and higher) as a surrogate indicator effectiveness.
The decline in advanced breast cancer stages is presumably the most relevant surrogate parameter mammography screening. It represents last step causal cascade that expected to affect cancer-related mortality. To assess effectiveness of population-based screening, we analyzed 2-year incidence rates cancers between women participating initial and first subsequent round.The study included data from 19,563 18,034 examinations one digital screening unit (2008 - 2010). Data on tumor stages,...
<b>Purpose:</b> The decline in advanced breast cancer stages is presumably the most relevant surrogate parameter mammography screening. It represents last step causal cascade that expected to affect cancer-related mortality. To assess effectiveness of population-based screening, we analyzed 2-year incidence rates cancers between women participating initial and first subsequent round. <b>Materials methods:</b> study included data from 19 563 18 034 examinations one digital screening unit...
To investigate the association between age at screening and detection rates for ductal carcinoma in situ (DCIS) separately different nuclear grades after introduction of a population-based digital mammography program.The retrospective study was approved by ethics board did not require informed consent. In 733 905 women aged 50-69 years who participated program first time 2005-2008 (baseline examinations were performed with mammography), DCIS determined 5-year groups (detection per 1000...
Purpose To compare detection rates of ductal carcinoma in situ (DCIS), classified according to nuclear grade, between the prevalence round (baseline screening) and two subsequent screening rounds a population-based digital mammography program, assess differences over time. Materials Methods The cancer registry provided data for 1970 graded pure DCIS cases from 16 regions screening, 2005 2008), first round, second round; interval all was 22-30 months. Age-adjusted logistic regression analysis...
The goal of the German Mammography Screening Program (MSP) is to enable early detection and less intensive treatment breast cancer. We compared tumor characteristics prognostic markers in cancers that were detected by screening MSP, interval after a negative screening, or among non-participants screening.This retrospective series includes all 1531 cases invasive situ cancer (DCIS, ductal carcinoma situ) newly diagnosed two certified care centers Münster period 2006-2012 women MSP target...
<b>Hintergrund:</b> Die Umwandlung von Adressdaten in geografische Koordinaten (Geokodierung) nimmt einen immer größeren Stellenwert der epidemiologischen Forschung als auch im öffentlichen Gesundheitssektor ein. Verzerrungen Geokodierung können zu einem nicht unerheblichen Bias diesen Studien führen und wurden bisher nur unzureichend untersucht. Ziel dieser Studie war es, die kostenfreien Geokodierungsdienste Google OpenStreetMap (OSM) hinsichtlich ihrer Vollständigkeit referenzierenden...
We present a framework for data management processes in population-based medical registries. Existing guidelines lack the concreteness we deem necessary them to be of practical use, especially concerning establishment new Therefore, propose adjustments and concretisations with regard quality, privacy, security registry purposes.First, separately elaborate on issues included into proposals their improvements. Thereafter, provide registries based quasi-standard-operation procedures.The main...
There is a rising public and political demand for prospective cancer cluster monitoring. But there little empirical evidence on the performance of established detection tests under conditions small heterogeneous sample sizes varying spatial scales, such as are case most existing population-based registries. Therefore this simulation study aims to evaluate different methods, implemented in open soure environment R, their ability identify clusters lung using real-life data from an...
The population-based mammography screening program (MSP) was implemented by the end of 2005 in Germany, and all women between 50 69 years are actively invited to a free biennial examination. However, despite expected benefits, overall participation rates range only 55%. There is also increasing evidence that belonging vulnerable population, such as ethnic minorities or low income groups, associated with decreased likelihood participating programs. This study aimed analyze more detail...
Die personenidentifizierenden Daten aller neu an Krebs Erkrankten werden im Epidemiologischen Krebsregister NRW (EKR NRW) ausschließlich in verschlüsselter Form gespeichert. Abgleiche mit Kohorten aus Sekundärdatenbeständen müssen daher anhand eines Record Linkage auf der Basis von Kryptogrammen Personendaten (sog. Kontrollnummern) durchgeführt werden. In dieser Pilotstudie wurden einem Disease-Management-Programm für Patienten Diabetes mellitus Typ 2 (DMP-DM2) dem Datenbestand des EKR...