A5080718813- Neuroscience and Neuropharmacology Research
- Cannabis and Cannabinoid Research
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Spinal Cord Injury Research
- Ion channel regulation and function
- Medicinal Plants and Neuroprotection
- Biochemical Analysis and Sensing Techniques
- Medicinal Plants and Bioactive Compounds
- Nicotinic Acetylcholine Receptors Study
- Mitochondrial Function and Pathology
- Anesthesia and Neurotoxicity Research
- Biochemical effects in animals
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience of respiration and sleep
- Hearing, Cochlea, Tinnitus, Genetics
- Botanical Research and Chemistry
- Genetic Neurodegenerative Diseases
- Pain Mechanisms and Treatments
- Barrier Structure and Function Studies
- High Altitude and Hypoxia
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
Mexican Social Security Institute
2016-2025
Universidad de Guadalajara
2008-2024
Madigan Army Medical Center
2018-2021
Secretaría de Salud de Jalisco
2009
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and characterized by loss dopaminergic neurons in substantia nigra (SN). Although causes PD are not understood, evidence suggests that its pathogenesis associated with oxidative stress inflammation. Recent studies have suggested a protective role cannabinoid signalling system PD. β-caryophyllene (BCP) natural bicyclic sesquiterpene an agonist type 2 receptor (CB2R). Previous BCP exerts prophylactic and/or curative...
Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders such as depression in diabetic patients, complicating the course of treatment. Drugs currently used to treat NP have undesirable side effects, so research on other natural sources has been required. β-caryophyllene (BCP), a sesquiterpene found some food condiments considered an agonist cannabinoid receptor type 2, could potential therapeutic effects conditions disorders. For this reason, we assessed...
Estimation of the neurological prognosis infants suffering from perinatal asphyxia and signs hypoxic-ischemic encephalopathy is great clinical importance; however, it remains difficult to satisfactorily assess these with current standard medical practices. Prognoses are typically based on data obtained examinations tests, such as electroencephalography (EEG) neuroimaging, but their sensitivities specificities far optimal, they do not always reliably predict future sequelae. In an attempt...
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide. Although precise pathogenesis of PD remains unclear, several studies demonstrate that oxidative stress, inflammation, low levels antioxidants, and presence biomolecules generate reactive oxygen species can disrupt blood-brain barrier (BBB) as an essential feature disease. This study aimed to test whether agonism cannabinoid receptor type 2 (CB2) through administration β-caryophyllene (BCP) could...
Guineensine is a dietary N-isobutylamide widely present in black and long pepper (Piper nigrum Piper longum) previously shown to inhibit cellular endocannabinoid uptake. Given the role of endocannabinoids inflammation pain reduction, here we evaluated guineensine mouse models acute inflammatory endotoxemia. Significant dose-dependent anti-inflammatory effects (95.6 ± 3.1% inhibition at 2.5 mg/kg ip 50.0 15.9% edema formation 5 ip) analgesia (66.1 28.1% 5.0 were observed. Moreover, inhibited...
It has recently been shown that the administration of probiotics can modulate microbiota-gut-brain axis and may have favorable effects in models Parkinson's disease. In this study, we used a hemiparkinsonism model induced by neurotoxin 6-OHDA to evaluate efficacy four-week mixture containing microorganisms Lactobacillus fermentum LH01, reuteri LH03, plantarum LH05. The an increase rotations apomorphine test, along with decrease latency time fall rotarod test on days 14 21 after surgery,...
Abstract Pro‐inflammatory cytokines TNF‐α, IL‐1β and IL‐6 rises significantly during neuronal damage activate the signaling p38 MAPK pathway, which is involved in apoptotic (AP) death. Systemic administration of glutamate as monosodium salt (MSG) to newborn animals induces death, however whether neurons die by AP or necrosis through pathway activation it unknown. In this study, expression levels, death cellular type that produces TNF‐α was also identified cerebral cortex (CC) striatum (St)...
Purpose . The aim of this study was to assess the effect melatonin in proliferation neural progenitors, concentration, and antiapoptotic proteins hippocampus adult mice exposed 96 h REM sleep deprivation (REMSD) prophylactic administration for 14 days. Material Methods Five groups Balb/C were used: (1) control, (2) REMSD, (3) (10 mg/kg) plus (4) intraperitoneal luzindole (once a day at 5 (5) REMSD. To measure content hippocampal tissue we used HPLC. Bcl‐2 Bcl‐xL measured by Western Blot...
Aging is associated with detrimental cellular and cognitive changes, making it an important public health concern; yet, many of these changes may be influenced by nutritional interventions. The natural sesquiterpene β-caryophyllene (BCP) has anti-inflammatory antioxidant effects that are mediated cannabinoid type-2 receptor activation, actions promote neuroprotection in different animal models involve a damage. Consequently, whether chronic administration BCP might prevent the age-related...
BackgroundCardiorenal syndrome (CRS) type 4 is prevalent among the chronic kidney disease (CKD) population, with many patients dying from cardiovascular complications. However, limited data regarding cardiac transcriptional changes induced early by CKD available.MethodsWe used a murine unilateral ureteral obstruction (UUO) model to evaluate renal damage, remodeling, and regulation at 21 days post-surgery through histological analysis, RT-qPCR, RNA-seq, bioinformatics.ResultsUUO leads...
Melatonin is a pleiotropic molecule that, after short-term sleep deprivation, promotes the proliferation of neural stem cells in adult hippocampus. However, this effect has not been observed long-term deprivation. The precise mechanism exerted by melatonin on modulation entirely elucidated, but evidence indicates that epigenetic regulators may be involved process. In study, we investigated treatment during 96-hour deprivation and analyzed expression modulators predicted computational text...
Parkinson's disease is a neurodegenerative disorder characterised by balance problems, muscle rigidity, and slow movement due to low dopamine levels loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The endocannabinoid system known modulate nigrostriatal pathway through endogenous ligands such as anandamide (AEA), which hydrolysed fatty acid amide hydrolase (FAAH). purpose this study was increase AEA using FAAH inhibitor URB597 evaluate modulatory effect on neuronal...