A5066957906- Cannabis and Cannabinoid Research
- Herbal Medicine Research Studies
- Forensic Toxicology and Drug Analysis
- Neuroscience and Neuropharmacology Research
- Natural Compound Pharmacology Studies
- Cholinesterase and Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Pancreatic function and diabetes
- Toxin Mechanisms and Immunotoxins
- Pharmacogenetics and Drug Metabolism
- GABA and Rice Research
- Psychedelics and Drug Studies
- Medicinal Plant Extracts Effects
- Pharmacological Effects of Natural Compounds
- Chemical Reactions and Isotopes
- Acne and Rosacea Treatments and Effects
- Receptor Mechanisms and Signaling
- Complementary and Alternative Medicine Studies
- Pharmaceutical studies and practices
- Transgenic Plants and Applications
- Biochemical Analysis and Sensing Techniques
- Phytochemistry and biological activity of medicinal plants
- Polyamine Metabolism and Applications
- Neuroscience of respiration and sleep
- Piperaceae Chemical and Biological Studies
University of Bern
2012-2022
Max Zeller Söhne (Switzerland)
2017-2020
Despite extensive research on the trafficking of anandamide (AEA) across cell membranes, little is known about membrane transport other endocannabinoids, such as 2-arachidonoylglycerol (2-AG). Previous studies have provided data both in favor and against a carrier-mediated using different methodological approaches. Because AEA 2-AG undergo rapid almost complete intracellular hydrolysis, we employed combination radioligand assays absolute quantification cellular extracellular endocannabinoid...
Significance Suitable chemical tools have been instrumental in the discovery and characterization of endocannabinoid system. However, lack potent selective inhibitors for transport has prevented molecular this process. Current uptake are poorly bioavailable to central nervous system (CNS) weakly because they also inhibit fatty acid amide hydrolase (FAAH), major anandamide-degrading enzyme. Few studies addressed inhibition 2-arachidonoyl glycerol (2-AG), which is endocannabinoid. Here, we...
The discovery of the interaction plant-derived N-alkylamides (NAAs) and mammalian endocannabinoid system (ECS) existence a plant endogenous N-acylethanolamine signaling have led to re-evaluation this group compounds. Herein, isolation seven NAAs assessment their effects on major protein targets in ECS network are reported. Four NAAs, octadeca-2E,4E,8E,10Z,14Z-pentaene-12-ynoic acid isobutylamide (1), 2′-methylbutylamide (2), hexadeca-2E,4E,9Z-triene-12,14-diynoic (3),...
Hypericum perforatum L . (St. John's wort) is used to treat mild‐to‐moderate depression. Its potential safety risks are pharmacokinetic drug interactions via cytochrome P450 (CYP) enzymes and P‐glycoprotein, presumably caused by hyperforin. In a phase I, open‐label, nonrandomized, single‐sequence study, the low‐hyperforin extract Ze 117 was investigated using cocktail in 20 healthy volunteers. No of were observed for CYP 1A2, 2B6, 2C9, 2C19, 3A4, P‐glycoprotein. Area under curve ( AUC ) peak...
Stress is an increasing problem that can result in various psychiatric and somatoform symptoms. Among others, benzodiazepines valerian preparations are used to treat stress The aim of this study was investigate whether the prescription a fixed herbal extract combination valerian, lemon balm, passionflower, butterbur (Ze 185) changes pattern hospitalized patients. In retrospective case‐control study, anonymized medical record data from 3,252 in‐house patients were analysed over 3.5‐year...
WOBE437 ((2E,4E)-N-(3,4-dimethoxyphenethyl)dodeca-2,4-dienamide, 1) is a natural product-derived, highly potent inhibitor of endocannabinoid reuptake. In this study, we synthesized almost 80 analogues 1 with different types modifications in the dodecadienoyl domain as well dimethoxyphenylethyl head group, and investigated their effects on anandamide uptake into U937 cells. Intriguingly, none these was more than (1). At same time, number variants exhibited potencies sub-100 nM range, high...
Guineensine ((2E,4E,12E)-13-(benzo[d][1,3]dioxol-5-yl)-N-isobutyltrideca-2,4,12-trienamide) is a plant-derived natural product that inhibits reuptake of the endocannabinoid anandamide with sub-micromolar potency. We have established highly efficient total synthesis guineensine, which provided in only five steps from commercially available 3-nonyn-1-ol 17 % overall yield, relying on attachment benzodioxolyl moiety to unsaturated fatty acid chain by means Suzuki coupling as key step....
Echinacea purpurea broadly inhibits coronaviruses and SARS-CoV-2 in vitro [1]. This review discusses the available evidence from human studies. A literature search on PubMed EMBASE yielded two RCTs with results coronavirus infections during prevention purpurea. Incidence viral loads were measured by reversed transcriptase polymerase chain reaction (RT-PCR). Jawad (2012) collected nasopharyngeal swabs N=755 adults over 4 months of prevention. Overall, 24 47 enveloped virus occurred, including...
Background Hypericum perforatum L. (St. John’s wort) is used to treat mild-to-moderate depression. Its potential safety risks are pharmacokinetic drug interactions via cytochrome P450 enzymes and P-glycoprotein, presumably caused by hyperforin.
Stress is an increasing problem that can result in various psychiatric and somatoform symptoms. Among others, benzodiazepines valerian preparations are used to treat stress
Abstract Echinacea purpurea was shown to broadly inhibit coronaviruses and SARS-CoV-2 in vitro. This review discusses the available clinical evidence from randomized, blinded controlled human studies. Two RCTs with results on enveloped viruses, respectively coronavirus infections during prevention treatment were detected. Incidence and/or viral loads measured by RT-PCR symptom severity recorded. Jawad et al. (2012) collected nasopharyngeal swabs adults (N=755) over 4 months of continuous...