A5084183893- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Natural product bioactivities and synthesis
- Plant-based Medicinal Research
- Sesquiterpenes and Asteraceae Studies
- Essential Oils and Antimicrobial Activity
- Biological Activity of Diterpenoids and Biflavonoids
- Biological and pharmacological studies of plants
- Traditional and Medicinal Uses of Annonaceae
- Plant Toxicity and Pharmacological Properties
- Fungal Biology and Applications
- Phytochemical compounds biological activities
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Medicinal plant effects and applications
- Chemical synthesis and alkaloids
- Traditional Chinese Medicine Analysis
- Plant and animal studies
- Ginseng Biological Effects and Applications
- Bioactive Compounds and Antitumor Agents
- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Bioactive Compounds
- Plant chemical constituents analysis
University of Szeged
2015-2024
Hungarian Academy of Sciences
1998-2023
Yeditepe University
2020
Seascape Consultants (United Kingdom)
2020
Caterpillar (United States)
2020
Eötvös Loránd University
2018
Farmak (Czechia)
2018
Kaohsiung Medical University
2016
Tunis El Manar University
2015
University of Graz
2008
Bryophyllum pinnatum (Lank.) Oken (Crassulaceae) is a perennial succulent herb widely used in traditional medicine to treat many ailments. Its wide range of uses folk justifies its being called "life plant" or "resurrection plant", prompting researchers' interest. We describe here the isolation and structure elucidation antimicrobial and/or antioxidant components from EtOAc extract B. pinnatum.The methanol displayed both activities with minimum inhibitory concentration (MIC) values ranging...
Abstract The role of quorum sensing (QS) is well known in microbial pathogenicity and antibiotic resistance. QS responsible for motility, swarming, biofilm production based on the signal molecules, e.g., acylated homoserine lactones (AHLs) produced by micro‐organisms above certain population density. inhibition may reduce pathogenicity, resistance formation systemic local infections. other transmitters contribute to several bacteria; consequently signals reduces problem virulence. Due...
Abstract Diterpenes occurring in plants of the Euphorbiaceae family are considerable interest context natural product drug discovery programs because their wide range potentially valuable biological activities and broad structural diversity due to different polycyclic macrocyclic skeletons various aliphatic aromatic ester groups. Euphorbia species have provided many lead compounds (resiniferatoxin, prostratin, jatrophane pepluane esters) for development, some which currently involved...
Three alkaloids, lycorine, homolycorine and 2-O-acetyllycorine, were isolated from the bulbs of Leucojum vernum (Amaryllidaceae) identified by means NMR analysis. The alkaloids obtained L. other Amaryllidaceae species studied in vitro for HIV-1 replication inhibitory activity on MT4 cells. cytotoxicity compounds uninfected cells was evaluated using MTT assay [3 H]thymidine incorporation test. antiviral activities determined p24 antigen solid-phase reverse transcriptase testing. results...
Abstract The antiproliferative activities of n ‐hexane, chloroform, aqueous‐methanol and aqueous extracts the aerial parts Achillea millefolium aggregate on three human tumour cell lines were investigated by means MTT assays. chloroform‐soluble extract exerted high proliferation inhibitory HeLa MCF‐7 cells, a moderate effect A431 cells; accordingly, it was subjected to detailed bioactivity‐guided fractionation. As result multistep chromatographic purifications (VLC, CPC, PLC, gel...
Abstract From the n ‐hexane fraction of fruits Vitex agnus‐castus , two labdane‐type diterpenes, vitetrifolin B and C, were isolated by means multiple chromatographic separations, together with previously identified rotundifuran, vitexilactone sesquiterpene spathulenol. EtOAc fraction, eupatorin was for first time, besides known casticin, penduletin, vitexin orientin. The ‐hexane, MeOH–H 2 O fractions MeOH extract Agni‐casti fructus subjected to in vitro antioxidant assays. displayed a...
Origanum majorana L. is a widely used medicinal plant; its distilled oil and preparations are extensively utilised in the phytotherapy food industries. The objective of this study to evaluate extracts essential (EO) L, monoterpenes for antimicrobial, bacterial multidrug resistance reversing, biofilm formation inhibitory potency. composition EO n-hexane extract was characterized by GC-MS. In terpinen-4-ol (24.92%), trans-sabinene hydrate (25.18%), γ-terpinene (6.48%), cis-sabinene (5.44%),...
The increase in bacterial resistance to currently available medications, which increases mortality rates, treatment costs is a global problem, and highlights the need for novel classes of antibacterial agents or new molecules that interact synergistically with antimicrobials.
The effects of 15 jatrophane diterpene polyesters (1−3 and 5−16) isolated from lipophilic extracts Euphorbia serrulata, E. esula, salicifolia, peplus (Euphorbiaceae) on the reversion multidrug resistance mouse lymphoma cells were examined. structures five new compounds (1−5) elucidated by spectroscopic methods, including HRFABMS, ESIMS, 1H−1H homonuclear 1H−13C heteronuclear correlations, long-range correlation spectra, NOESY experiments. stereochemistry absolute configuration one compound...
Abstract The antiproliferative activities of aqueous and organic extracts prepared from 26 Hungarian species the tribes Cynereae Lactuceae (Asteraceae) were tested in vitro against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) MCF7 (breast adenocarcinoma) cells by using MTT assay. Of 200 different plant parts obtained with n ‐hexane, chloroform, 50% methanol water, 16 displayed noteworthy cell growth inhibitory activity (>50% inhibition at a concentration 10...