A5088424354- AI in cancer detection
- Infrared Thermography in Medicine
- Radiomics and Machine Learning in Medical Imaging
- Telomeres, Telomerase, and Senescence
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Sleep and Wakefulness Research
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Digital Radiography and Breast Imaging
- Cardiovascular Disease and Adiposity
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Artificial Intelligence in Healthcare
- Extracellular vesicles in disease
- Orthopaedic implants and arthroplasty
- Anesthesia and Neurotoxicity Research
- Inflammasome and immune disorders
- Cell Image Analysis Techniques
- Digital Imaging for Blood Diseases
- Ultrasound Imaging and Elastography
- Multiple Sclerosis Research Studies
- Pharmacovigilance and Adverse Drug Reactions
Centro de Investigación y Proyectos en Ambiente y Desarrollo
2016
Universidad de Guadalajara
2016
Mexican Social Security Institute
2009-2012
Amyloid-beta (Aβ) pathology is related to mitochondrial dysfunction accompanied by energy reduction and an elevated production of reactive oxygen species (ROS). Monomers oligomers Aβ have been found inside mitochondria where they accumulate in a time-dependent manner as demonstrated transgenic mice Alzheimer's disease (AD) brain. We hypothesize that the internalization extracellular aggregates major cause damage here we report following injection fibrillar into hippocampus, there severe...
Sleep deprivation (SD) affects spatial memory and proliferation in the dentate gyrus. It is unknown whether these deleterious effects persist long run. The aim of this study was to evaluate proliferation, differentiation maturation neural progenitors as well 21 days after suffering sleep deprivation. Sixty-day old male Balb/C mice were exposed 72-h REM-SD. Spatial memory, cell fate, apoptosis expression levels insulin-like growth factor 1 receptor (IGF-1R) evaluated hippocampus at 0, 14 SD...
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease that affects the nervous system. Peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) are potential biomarkers of neurological disability neural damage. Our objective was to assess LTL mtDNA-CN in relapsing-remitting MS (RRMS). We included 10 healthy controls, 75 patients with RRMS, 50 whom had an Expanded Disability Status Scale (EDSS) from 0 3 (mild moderate disability), 25 EDSS...
Purpose . The aim of this study was to assess the effect melatonin in proliferation neural progenitors, concentration, and antiapoptotic proteins hippocampus adult mice exposed 96 h REM sleep deprivation (REMSD) prophylactic administration for 14 days. Material Methods Five groups Balb/C were used: (1) control, (2) REMSD, (3) (10 mg/kg) plus (4) intraperitoneal luzindole (once a day at 5 (5) REMSD. To measure content hippocampal tissue we used HPLC. Bcl‐2 Bcl‐xL measured by Western Blot...
To evaluate new circulating markers related to macrovascular complications (MVC) in type 2 diabetes mellitus (T2DM), we recruited 30 controls (CG), 34 patients with T2DM (DG), and 28 vascular (DG+C), among them, 22 presented MVC. Pe-ripheral blood was used determine redox status (superoxide dismutase, SOD; catalase, CAT; glutathione reductase, GRd; peroxidase, GPx; glucose-6-phosphate dehydrogenase, G6PD) of oxidative damage (advanced oxidation protein products, AOPP; lipid pe-roxidation,...
Alzheimer pathogenesis involves mitochondrial dysfunction, which is closely related to amyloid- ß (A ) generation, abnormal tau phosphorylation, oxidative stress, and apoptosis. Alterations in membranal components, including cholesterol fatty acids, their characteristics, disposition, distribution along the membranes, have been studied as evidence of cell membrane alterations AD brain. The majority these studies focused on cytoplasmic membrane; meanwhile membranes less explored. In this...
The development of type 2 diabetes mellitus (T2DM) vascular complications (VCs) is associated with oxidative stress and chronic inflammation can result in endothelial dysfunctions. Circulating microRNAs play an important role epigenetic regulation the etiology T2DM. We studied 30 healthy volunteers, 26 T2DM patients no complications, VCs, to look for new biomarkers indicating a risk developing VCs patients. Peripheral blood samples were used determine redox state, by measuring endogenous...
Breast cancer (BC) diagnosis is made by a pathologist who analyzes portion of the breast tissue under microscope and performs histological evaluation. This evaluation aims to determine grade cellular differentiation aggressiveness tumor Nottingham Grade Classification System (NGS). Nowadays, digital pathology an innovative tool for pathologists in acquiring new learning. However, recurring problem health services excessive workload all medical services. For this reason, it required develop...
Breast cancer (BC) affects millions of women worldwide, causing over 500,000 deaths annually. It is the leading cause mortality in women, with 70% occurring developing countries. Elastography, which evaluates tissue stiffness, a promising real-time minimally invasive technique for BC diagnosis. This study assessed strain elastography (SE) and fat-to-lesion (F/L) index prospective included 216 who underwent SE, ultrasound, mammography, breast biopsy (108 malignant, 108 benign). Three expert...
Effective communication is crucial in daily life, and for people with hearing disabilities, sign language no exception, serving as their primary means of interaction. Various technologies, such cochlear implants mobile translation applications, have been explored to enhance improve the quality life deaf community. This article presents a new, innovative method that uses real-time machine learning (ML) accurately identify Mexican (MSL) adaptable any language. Our based on analyzing six...
To assay new circulating markers related to macrovascular complications (MVC) in type 2 diabetes mellitus (T2DM), we carried out a descriptive cross-sectional study. We recruited 30 controls (CG), 34 patients with T2DM (DG), and 28 vascular (DG+C); among them, 22 presented MVC. Peripheral blood was used determine redox status (superoxide dismutase, SOD; catalase, CAT; glutathione reductase, GRd; peroxidase, GPx; glucose-6-phosphate dehydrogenase, G6PD) of oxidative damage (advanced oxidation...
Identifying breast masses is relevant in early cancer detection. Automatic identification using computational methods helps assist medical experts with this task. Although high values have been reported mass classification from digital mammograms, most results focused on a general benign/malignant classification. According to the BI-RADS standard, are associated risk by grade depending their specific shape, margin, and density characteristics. This work presents methodology of testing...
Bone fractures are a worldwide public health concern. Therefore, improving understanding of the bone healing process at molecular level, which could lead to discovery potential therapeutic targets, is important. In present study, model open tibial with hematoma disruption, periosteal rupture and internal fixation in 6-month-old male Wistar rats was established, order identify expression patterns key genes their protein products throughout process. A shaft fracture produced using three‑point...
Reduced or null expression of E-cadherin protein is a frequent cause diffuse gastric cancer (DGC). More than 50% patients with DGC present somatic variants in CDH1 gene.The objectives this study were to and identify the gene tumors DGC.We studied 18 Mexican who attended hospital Social Security Institute; was determined by immunohistochemistry, identified Sanger sequencing promoter coding regions. Predictive analysis performed using PolyPhen-2 HOPE software.We found that 56% showed reduced...
Breast cancer (BC) affects millions of women; it is the leading cause death by neoplasia in wom-en worldwide, with at least 500 thousand deaths each year, 70% which occur developing countries. Elastography evaluates tissue stiffness, making this a promising non-invasive real-time technique. BI-RADS recognized as standard and helpful technique for establishing BC risk. This study aimed to determine, strain elastography (SE), fat-to-lesion index (F/L index), sen-sitivity, specificity, optimal...
With the use of computer-aided diagnostic systems, automatic detection and segmentation cell nuclei have become essential in pathology due to cellular counting nuclear pleomorphism analysis are critical for classification grading breast cancer histopathology. This work describes a methodology histopathology images obtained from BreakHis database, Standford tissue microarray Breast Cancer Cell Segmentation database. The proposed scheme is based on characterization Hematoxylin Eosin (H&E)...
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease that affects the nervous system. Peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) are potential biomarkers of disability neurological damage. The present work evaluated LTL mtDNA-CN in 75 relapsing-remittent MS (RRMS) patients 50 whom had an Expanded Disability Status Scale (EDSS) 0 to 3 (mild-moderate disability), 25 EDSS 3.5 7 (severe disability). Absolute absolute were...
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease that affects the nervous system. Peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) are potential biomarkers of disability neurological damage. The present work evaluated LTL mtDNA-CN in 75 relapsing-remittent MS (RRMS) patients 50 whom had an Expanded Disability Status Scale (EDSS) 0 to 3 (mild-moderate disability), 25 EDSS 3.5 7 (severe disability). Absolute absolute were...