Sleep deprivation (SD) affects spatial memory and proliferation in the dentate gyrus. It is unknown whether these deleterious effects persist long run. The aim of this study was to evaluate proliferation, differentiation maturation neural progenitors as well 21 days after suffering sleep deprivation. Sixty-day old male Balb/C mice were exposed 72-h REM-SD. Spatial memory, cell fate, apoptosis expression levels insulin-like growth factor 1 receptor (IGF-1R) evaluated hippocampus at 0, 14 SD...

Abstract OBJECTIVE The trans-supraorbital approach has the advantage of combining keyhole principle with cranial base surgery. anatomic fields that can be visualized use this procedure have been demonstrated in cadavers, and advantages potential surgical applications are described report. This article is first to describe a group intracranial supratentorial aneurysms. METHODS We used 22 cases In technique, an incision made through eyebrow, then 3.5-cm craniotomy performed en bloc extension...

The advent and growth of technological advances have led to new routes knowledge. Thereby, we currently face challenges. We just started get a glimpse the structural functional role neural stem cells in differentiation migration processes, origin synaptic networks, subsequent readjustments specific circuits. A whole range treatment possibilities originates from this knowledge that potentially can be used for different neurological diseases humans. Although is an encouraging scenario, it...

Anxiety and depressive symptoms are generated after paradoxical sleep deprivation (PSD). However, it is not clear whether PSD produces differential effects between females males. The aim of this study was to assess the effect on anxiety- depressive-like behaviors sexes. Male female BALB/c mice were divided in three groups: control group, 48-h group 96-h group. Immediately protocols, forced swimming open field test applied. Sucrose consumption used evaluate middle-term PSD. We found that...

Background: Breast cancer is a malignant disease that represents an important public health burden. The description of new molecular markers can be to diagnosis, classification, and treatment. Transient receptor potential vanilloid 1 (TRPV1) polymodal channel expressed in different neoplastic tissues cell lines breast associated with the regulation tumor growth, neurogenesis, pain, progression cancer. In primary metastatic tumors, TRPV1 during transformation, invasive behavior, resistance...

In this experiment, we evaluated the long-term effects of noise by assessing both astrocyte changes in medial prefrontal cortex (mPFC) and mPFC-related alternation/discrimination tasks. Twenty-one-day-old male rats were exposed during a period 15 days to standardized rats' audiogram-fitted adaptation human noisy environment. We measured serum corticosterone (CORT) levels at end exposure periodically registered body weight gain. order evaluate exposure, assessed performance on T-maze...

Study Design: Experimental study with an animal model.Purpose: To evaluate the role of a chitosan and hydroxyapatite composite for spinal fusion in lumbar experimental model based on regenerative tissue engineering principles.Overview Literature: Chitosan represent alternative biodegradable implant material regeneration. The combination 20:80 ratio could potentiate their individual properties as implantable laminectomy.Methods: Phase I: design synthesis porous scaffold composed...

The Mongolian gerbil is one of the main animal species used for study global ischemia, due to its specific Circle Willis. Because their anatomic variations, a large number animals needed. On account vulnerability hippocampus, striatum and neocortex, it possible evaluate severity ischemic damage through an analysis locomotor activity. tests support sensitvity experimental sample compensate interanimal variability.The pattern 30 male gerbils was recorded before they were subjected bilateral...

Introduction: Despite improvements in sanitation, diagnosis and treatment, neurocysticercosis is still a public health problem many countries. In symptomatic patients, there broad spectrum of clinical manifestations. When cysticerci are lodged the ventricles or subarachnoid space, flow cerebrospinal fluid can be obstructed lead to hydrocephalus intracranial hypertension. The endoscopic view may useful as diagnostic tool.

A microsurgical anterior cervical approach with discectomy and fusion (MACDF) is one of the most widely used procedures for treating radicular disorders. This highly successful; however, it not free from complications. These can be associated soft tissue injuries.The recognition risks these complications should identified timely prevention safe treatment.Retrospective case control study. study includes a retrospective series 37 patients, paying special attention to immediate related use...

<b>Introduction</b> The decompressive craniectomy is a surgical strategy widely used with specific criteria to control the refractory intracranial pressure (ICP). However, it important warn about presence of postcraniectomy syndrome and analyze risk-benefit on long term. <b>Case Report</b> A 72-year-old male patient diagnosed subarachnoid hemorrhage secondary rupture an anterior circulation aneurysm that develops vasospasm, ischemia, edema signs herniation required first step. Afterwards,...

The trans-supraorbital approach represents the advantage of combining keyhole principle and skull base surgery. In cadaveric work author shows anatomic fields visualized with this procedure, advantages potential surgical applications. experimental procedure was performed on 8 adult skulls 3 cadavers intact cerebral structures. First, a 2 cm supraorbital for endoscopic exploration used. basic landmarks corresponding dimensions microsurgical field were recorded then compared those from...

Basic research provides the results necessary to pursue translational work, where basic and approaches used in conjunction can allow for an increased impact solving public health problems. Biomaterials draws from both are today many surgical specialty areas, such as tissue regeneration regenerative medicine. These materials be replacements tissue, scaffolds regeneration, substrates cell growth, drug-releasing or bioactive molecule-releasing vehicles, several other medical devices....

Endoscopic endonasal transsphenoidal surgery (EETS) is a standard technique used to approach sellar tumors. It relatively safe, minimally invasive and carries low risk of complications. However, one the common complications reported with this CSF leakage which causes morbidity, an increase in recovery time hospital costs. This complication usually occurs from violation diaphragma sellae defect structures floor or incomplete repair. In article we report first case use novel bilaminar chitosan...

The peripheral hallmarks of neurofibromatosis type 1 (NF1) are Café au lait and solid nodular neurofibromas. morphological behavior these lesions could be susceptible to modification during pregnancy. present case report describes a cystic transformation neurofibroma, with progressive growth mass effect in the anterior cervical region, which was surgically resolved without any complications.A 33-year-old female patient known personal history NF1, annual control neurofibromas cerebral spinal...

Background. Education in the formation of human capital health constantly presents challenges. New tools emerging contexts may strengthen empathic attitudes. We developed an educational intervention that included a senescence simulator and assessed its impact on perception attitudes healthcare students. Methods. A cross-sectional comparative study was conducted acquired knowledge self-perception using semistructured survey administered before after demonstration reported experience through...