A5020382028- Neuroscience and Neuropharmacology Research
- Circadian rhythm and melatonin
- Neuroinflammation and Neurodegeneration Mechanisms
- Multiple Sclerosis Research Studies
- Gut microbiota and health
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Gastrointestinal motility and disorders
- Genomics, phytochemicals, and oxidative stress
- Neuroscience of respiration and sleep
- Biochemical Analysis and Sensing Techniques
- Heme Oxygenase-1 and Carbon Monoxide
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- Bee Products Chemical Analysis
- Paraquat toxicity studies and treatments
- Free Radicals and Antioxidants
- Probiotics and Fermented Foods
- Spectroscopy Techniques in Biomedical and Chemical Research
- Diet and metabolism studies
- Vitamin C and Antioxidants Research
- Advanced Chemical Sensor Technologies
- Pesticide Exposure and Toxicity
Mexican Social Security Institute
2013-2025
Universidad de Guadalajara
1999-2017
Centro de Investigación Biomédica en Red
2015
American University of Nigeria
2015
Universidad de Occidente
2007
Secretaría de Salud de Jalisco
2005
Consejo Superior de Investigaciones Científicas
2000
The University of Texas Health Science Center at San Antonio
1999
This paper highlights the relationship of inflammation and oxidative stress as damage mechanisms Multiple Sclerosis (MS), considered an inflammatory autoimmune disease. The concept has been defined by imbalance between oxidants antioxidants in favor oxidants. There is necessary to do physiological functions, like respiration chain, but certain conditions, production reactive species overpassed antioxidant systems, which could cause tissue damage. On other hand, it well established that a...
This paper highlights the relationship of inflammation and oxidative stress as damage mechanisms Multiple Sclerosis (MS), considered an inflammatory autoimmune disease. The concept has been defined by imbalance between oxidants antioxidants in favor oxidants. There is necessary to do physiological functions, like respiration chain, but certain conditions, production reactive species overpassed antioxidant systems, which could cause tissue damage. On other hand, it well established that a...
Abstract Pro‐inflammatory cytokines TNF‐α, IL‐1β and IL‐6 rises significantly during neuronal damage activate the signaling p38 MAPK pathway, which is involved in apoptotic (AP) death. Systemic administration of glutamate as monosodium salt (MSG) to newborn animals induces death, however whether neurons die by AP or necrosis through pathway activation it unknown. In this study, expression levels, death cellular type that produces TNF‐α was also identified cerebral cortex (CC) striatum (St)...
The present study was specifically designed to discern the possible existence of subgroups patients with relapsing-remitting form multiple sclerosis (RRMS) depending on their gender, age, disease stage (relapsing or remitting), time evolution and response different treatments.We analyzed samples from RRMS (50 females 32 males) healthy individuals (25 matched for age gender) determined serum concentrations IFN-γ, IL-10 IL-17A. We stratified by treatment time, subsequently correlated these...
Caustic ingestion is one of the most life-threatening events in pediatric age group, which requires immediate management and subsequent treatment its significant complication, i.e. alterations esophageal structure. We investigated whether melatonin could reduce burn damage induced by sodium hydroxide. It was assumed that be effective because function as a direct free radical scavenger, antioxidative actions ability to diminish tissue hydroxyproline (HP) levels. Esophageal burns were male...
The ultrastructure of the Atlantic Bottlenose dolphin Harderian gland (HG) has been described but some questions remain unanswered. purpose this work was to define gland's structure, and differences between cells (types I II) male using optic, fluorescence electron transmission microscopy. Three different were observed under optic microscopic examination, while only two cell types distinguished by Type (oval nuclear envelope) exhibited three populations type II (indented populations....
Progression to renal damage by ischemia-reperfusion injury (IRI) is the result of dysregulation various tissue repair mechanisms. Anesthetic preconditioning with opioids has been shown be beneficial in myocardial IRI models. Our main objective was analyze influence pharmacological function and expression molecules involved angiogenesis. Experimental protocol includes male rats 45 min ischemia occluding left hilum followed 24 h reperfusion or without 60 morphine/fentanyl. We analyzed serum...
Diabetes is associated with increased lipid peroxidation, quantified as the levels of thiobarbituric acid reactive substances (TBARS). In parallel, antioxidant defense system (ADS) reacts to diminish oxidative damage.To determine peroxidation and activity enzymes in obese type 2 diabetic (DM2) individuals compared non-obese DM2 individuals.Lipid was by measuring TBARS ADS response superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPx).Two groups 30 subjects were studied. The...
The purpose of this study was to compare the natural fluorescence in Harderian glands Syrian hamster, rat, mouse, Mongolian gerbil and guinea pig (both sexes). For each species, 10 animals (five males five females) were used. Histological autofluorescence studies performed using a microscope (450-490 nm filter). Two different types fluorescent cells observed both hamster (type AFI high intensity type AFII, low fluorescence) rat AFI, glands. basally located all mice cells, whereas it near...
The molecular epidemiology of subtypes and intersubtype recombinants (IRs) human immunodeficiency virus type 1 (HIV-1) in Mexico has not been characterized fully. Understanding its regional distribution, prevalence, adaptability, viral fitness, pathogenicity, immunogenicity is decisive for any design an effective HIV vaccine. aim this study was to describe the presence IRs types BG BF a Mexican population. Protease reverse transcriptase regions pol gene were sequenced using automated...
Bidirectional dependence exists between the immune and neuroendocrine systems, with common chemical messengers, such as melatonin (MLT), having immunoregulatory functions in some mechanisms of endotoxic shock. We used 10 – 12-week-old female Balb/c mice, an average weight 22 24 g, maintained under a 12 h light dark cycle. The LD100 lipopolysaccharide (LPS) was determined to be mg/kg (ip.) from dose response curve. Pretreatment MLT (10 ip.) increased survival by 60%, decreased plasma TNF-αε...
INTRODUCTION. The immune system and the peripheral central nervous are in constant communication by means of messengers signalling molecules released, such as cytokines, neuropeptides, neurohormones neurotransmitters, among others. Seizures defined transitory appearance signs symptoms that trigger an abnormally excessive neuronal activity brain. Following seizures generation a neuroinflammatory process has been observed to occur, with consequent release proinflammatory cytokines...