David García

ORCID: 0000-0002-0862-6070
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About
Contact & Profiles
Research Areas
  • Organ Transplantation Techniques and Outcomes
  • Anesthesia and Neurotoxicity Research
  • Liver Disease Diagnosis and Treatment
  • Cardiac Ischemia and Reperfusion
  • Pediatric Pain Management Techniques
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Gastrointestinal disorders and treatments
  • Chronic Kidney Disease and Diabetes
  • Nitric Oxide and Endothelin Effects
  • Acute Kidney Injury Research
  • Liver Disease and Transplantation
  • Stress Responses and Cortisol
  • Gastrointestinal Tumor Research and Treatment
  • Genomics and Chromatin Dynamics
  • Intensive Care Unit Cognitive Disorders
  • Single-cell and spatial transcriptomics
  • Wireless Body Area Networks
  • Telomeres, Telomerase, and Senescence
  • Cardiac electrophysiology and arrhythmias
  • Receptor Mechanisms and Signaling
  • Botulinum Toxin and Related Neurological Disorders
  • Body Composition Measurement Techniques
  • Pain Mechanisms and Treatments
  • Pain Management and Placebo Effect

Mexican Social Security Institute
2017-2024

Consejo Nacional de Humanidades, Ciencias y Tecnologías
2020

Hospital de León
2017

Alexander T. Augusta Military Medical Center
2014

Valencia Catholic University Saint Vincent Martyr
2013

BACKGROUND: Renal transplant surgical proceedings are known to elicit periods of hypoxia and consequent blood flow reestablishment triggering ischemia-reperfusion (I-R) injury. Kidney damage induced by I-R injury associates with a higher risk graft dysfunction rejection. Anesthetic preconditioning exerts beneficial effect on reducing oxidative stress, inflammation apoptosis. However, the degree renoprotection stimulated commonly used anesthetics, as well their mechanisms action, largely...

10.23736/s0393-2249.19.03361-7 article EN Minerva Urologica e Nefrologica 2020-04-01

The targeting of transforming growth factor β (TGF-β) has been shown to reduce complications related ischemia-reperfusion injury (IRI) post-surgically. Pirfenidone (PFD) specifically inhibits TGF-β expression and demonstrated provide protection from IRI in short-term allograft models, though not yet long-term models. A chronic unilateral model was established using male Wistar rats. animals were divided into two groups: one with a pre-treatment PFD (0.5 mg/kg) followed by 0.5 mg/kg/day...

10.3390/ddc2010009 article EN cc-by Drugs and Drug Candidates 2023-03-13

Liver cancer is the fourth leading cause of cancer-related death worldwide. In Mexico, there a high burden liver mortality in rural states, which affects both women and men equally. Thus, we aimed to describe demographic clinical characteristics hepatocellular (HCC) by sex Mexico. Demographic information were extracted retrospectively from medical records patients with HCC initially treated (2015-2022) at participating institutions national survey across country. The male-to-female ratio was...

10.20944/preprints202405.1998.v1 preprint EN 2024-05-30

Progression to renal damage by ischemia-reperfusion injury (IRI) is the result of dysregulation various tissue repair mechanisms. Anesthetic preconditioning with opioids has been shown be beneficial in myocardial IRI models. Our main objective was analyze influence pharmacological function and expression molecules involved angiogenesis. Experimental protocol includes male rats 45 min ischemia occluding left hilum followed 24 h reperfusion or without 60 morphine/fentanyl. We analyzed serum...

10.3390/ph13110387 article EN cc-by Pharmaceuticals 2020-11-14

Several studies have reported an increase in breast cancer (BC) risk when patients are carriers of the CYP19 TTA polymorphism with ≥10 repeats; moreover, it has been that telomere length is associated a higher susceptibility developing cancer.The objective this study was to understand relationship between TTTA repetition and its effects on serum estradiol, estrone follicle-stimulating hormone (FSH).A total 180 postmenopausal healthy 70 BC-diagnosed women were included. Telomere determined...

10.2147/bctt.s125431 article EN cc-by-nc Breast Cancer Targets and Therapy 2017-01-01

Abstract Background Some evidence has been found that malignant breast tumors have lower electrical impedance than surrounding normal tissues. Electrical could be used as an indicator for cancer detection. Methods Is a prospective, cross-sectional epidemiological observational study of serial screening. The women were invited to participate and signed their consent letter. purpose our was analyze the sensitivity specificity mammography (EIM) its implementation differential diagnosis...

10.21203/rs.2.12298/v1 preprint EN cc-by Research Square (Research Square) 2019-08-02
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