A5031576433- Circadian rhythm and melatonin
- Biochemical Acid Research Studies
- Coenzyme Q10 studies and effects
- Sleep and related disorders
- Adipose Tissue and Metabolism
- Lipid Membrane Structure and Behavior
- Alzheimer's disease research and treatments
Universidad de Guadalajara
2008-2021
Sleep disorders are a widespread condition in patients with Parkinson's disease (PD), which has been linked to deregulation of the circadian cycle and therefore clock genes. The aim this study was evaluate effect melatonin (MEL) on PER1 BMAL1 genes PD. A double-blind, cross-over, placebo-controlled randomized clinical trial pilot conducted 26 stage 1-3 PD according Hoehn & Yahr scale, who received either 25 mg MEL or placebo at noon 30 min before bedtime for three months. relative expression...
Mitochondrial dysfunction and oxidative stress are extensively linked to Parkinson's disease (PD) pathogenesis. Melatonin is a pleiotropic molecule with antioxidant neuroprotective effects. The aim of this study was evaluate the effect melatonin on markers, mitochondrial complex 1 activity, respiratory control ratio in patients PD. A double-blind, cross-over, placebo-controlled randomized clinical trial conducted 26 who received either 25 mg or placebo at noon 30 min before bedtime for three...
It has been suggested that mitochondrial dysfunction and defects in membrane structure could be implied AD pathogenesis. The aim of the present work was study fluidity submitochondrial platelet particles erythrocyte membranes from Mexican patients. Blood samples were obtained 30 patients with Alzheimer disease aged‐matched control subjects. Membrane determinations done using a very low concentration fluorescent dipyrenylpropane probe incorporated both types membranes. This is able to give...