A5026992178- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Antioxidant Activity and Oxidative Stress
- Neurogenesis and neuroplasticity mechanisms
- Long-Term Effects of COVID-19
- Phytochemicals and Antioxidant Activities
- Dialysis and Renal Disease Management
- Medicinal Plants and Neuroprotection
- Erythropoietin and Anemia Treatment
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- Light effects on plants
- Kruppel-like factors research
- Healthcare and Venom Research
- 3D Printing in Biomedical Research
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Biochemical and Structural Characterization
- Pluripotent Stem Cells Research
- Machine Learning in Materials Science
- Nerve injury and regeneration
- Food Chemistry and Fat Analysis
Tecnológico de Monterrey
2022-2024
Secretaría de Salud de Jalisco
2017-2021
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco
2017-2021
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2018-2021
Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment. The purpose of this study was to investigate the effects on neurogenesis capacity in a mouse model Alzheimer's disease. disease models were established by injection beta amyloid 1−42 aggregates into dentate gyrus bilaterally. Morris water maze novel object recognition tests performed evaluate deficits at 14 28 days after administration. Afterwards, subventricular...
Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity have been recognized as the locus of long-term synaptic plasticity related to cognitive processes such learning memory. In neurodegenerative diseases, spine morphology alteration, shape density, affects functional characteristics leading dysfunction impairment. Recent evidence implicates a critical feature pathogenesis dementia, particularly Alzheimer's disease. The alteration their loss is...
Alzheimer's disease (AD) is a chronic brain disorder characterized by progressive intellectual decline and memory neuronal loss, caused mainly extracellular deposition of amyloid-β (Aβ) intracellular accumulation hyperphosphorylated tau protein, primarily in areas implicated learning as prefrontal cortex hippocampus. There are two forms AD, late-onset form that affects people over 65 years old, the early-onset form, which hereditable affect at early ages ~45 years. To date, there no cure for...
The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core γ-secretase complex that conducts intramembranous proteolytic excision multiple transmembrane proteins like amyloid precursor protein, Notch-1, N- E-cadherin, LRP, Syndecan, Delta, Jagged, CD44, ErbB4, Nectin1a. plays an...
Ultrasound-assisted extraction (UAE) is an efficient and sustainable method for extracting bioactive compounds from agro-industrial by-products. Moreover, it has been reported that ultraviolet A (UVA) radiation can induce the biosynthesis accumulation of phenolic compounds. This study optimized efficiency ultrasound-assisted recovering (UVA)-induced in strawberry by-products (RF-N). The impact three factors (solid-liquid ratio, ethanol concentration, ultrasound power) on total compound (TPC)...
Globally, the rise in neurodegenerative issues tandem with shifts lifestyle and aging population has prompted a search for effective interventions. Nutraceutical compounds have emerged as promising agents addressing these challenges. This 60-day study on an aluminum-induced cognitive impairment rat model assessed three their combinations: probiotics (Prob, Lactobacillus plantarum [5 × 1010 CFU/day], acidophilus CFU/day]), docosahexaenoic acid (DHA, 23.8 mg/day), vitamin D3 (VD3, 150 IU/day)....
Using wounding stress to increase the bioactive phenolic content in fruits and vegetables offers a promising strategy enhance their health benefits. When wounded, such phenolics accumulate plants can provide antioxidant, anti-inflammatory, anti-obesogenic properties. This study investigates potential of using stress-treated carrots biofortified with compounds as raw material extract carrot juice increased nutraceutical Fresh were subjected via slicing then stored at 15 °C for 48 h allow...
This study evaluated the health benefits of carrots (Daucus carota) subjected to post-harvest wounding stress, emphasizing their anti-obesogenic, anti-inflammatory, and antioxidant properties. Carrots were shredded stored at 15 ± 2 °C for 48 h induce leading a significant increase in chlorogenic acid content, by over 112.5% compared control. The utilized 3T3-L1 cell differentiation assays evaluate anti-obesogenic potential, monitoring changes lipid accumulation adipogenesis-related gene...
Lanthanide-based nanomaterials offer a promising alternative for cancer therapy because of their selectivity and effectiveness, which can be modified predicted by leveraging the improved accuracy enhanced decision-making machine learning (ML) modeling.
This study investigates the bioactivity retention of chlorogenic acid (CGA) and its metabolite dihydrocaffeic (DHCA) by comparing their antioxidant, anti-inflammatory, anti-obesogenic properties in vitro. CGA, found coffee, fruits, vegetables, is metabolized into DHCA, potentially enhancing bioactivity. Antioxidant capacity was assessed Caco-2 cells, with DHCA showing superior activity at lower concentrations than CGA. Anti-inflammatory effects were evaluated LPS-stimulated RAW 264.7 where...
Metabolic syndrome is a condition characterized by metabolic alterations that culminate in chronic noncommunicable diseases of high morbidity and mortality, such as cardiovascular diseases, type 2 diabetes, nonalcoholic fatty liver disease, colon cancer. Developing new therapeutic strategies with multifactorial approach important since current therapies focus on only one or two components the syndrome. In this sense, plant-based gene regulation represents an innovative strategy to prevent...
Oligodendrocyte precursor cell (OPC) migration is a mechanism involved in remyelination; these cells migrate from niches the adult CNS. However, age and disease reduce pool of OPCs; as result, remyelination capacity CNS decreases over time. Several experimental studies have introduced OPCs to brain via direct injection or intrathecal administration. In this study, we used nose-to pathway deliver oligodendrocyte lineage (human oligodendroglioma (HOG) cells), which behave similarly vitro. To...
The treatment of such primary brain tumours as glioblastoma multiforme (GBM) presents numerous difficulties, considerably impacting patient survival rates. search for new compounds with therapeutic potential focuses on the identification molecules that can be produced through chemical and enzymatic processes present anticancer effects in different types tumours. Given need treatments GBM, we conducted a study to synthesise ortho-coumaric acid alkyl esters (OCAAE) evaluate them an appropriate...
La enfermedad renal crónica (ERC) puede provocar anemia e inducir afectaciones neurológicas. eritropoyetina humana recombinante (rHuEPO) se utiliza en el tratamiento de la ERC. Sin embargo, existe poca evidencia los efectos rHuEPO sobre conducta y las funciones cognitivas El objetivo este estudio fue evaluar efecto del con sensoriomotoras un modelo Ratas macho cepa Wistar fueron asignadas a 4 grupos: control ERC, sin (1.050 UI/kg peso, una vez por semana durante semanas). Las pruebas...
Chronic kidney disease (CKD) can cause anaemia and neurological disorders. Recombinant human erythropoietin (rHuEPO) is used to manage in CKD. However, there little evidence on the effects of rHuEPO behaviour cognitive function This study aimed evaluate impact sensorimotor functions a CKD model. Male Wistar rats were randomly assigned 4 groups: control CKD, with without treatment (1050 IU per kg body weight, once weekly for weeks). The Morris water maze, open field, adhesive removal tests...
Cognition and brain function is critical through childhood should be improved with balanced diets. Incorporating bioactive ingredients such as omega-3 polyunsaturated fatty acids (ω3 PUFAs) probiotics into food formulations could used an approach to improve cognitive function. This study evaluated the effects on capacity of complementing rodent diets chocolate, by itself in combination ω3 PUFAs from fish oil probiotics.Spatial learning memory rats were determined Barnes maze test short-...
The consumption of vegetables is essential for reducing the risk noncommunicable diseases, yet global intake falls short recommended levels. Enhancing nutraceutical content through postharvest abiotic stress, such as ultraviolet B (UVB) radiation, offers a promising solution to increase health benefits. This study developed user-friendly, at-home UVB device designed phytochemical in common like carrots, lettuce, and broccoli. applies radiation (305–315 nm) fresh-cut vegetables, optimizing...