A5039427885- Curcumin's Biomedical Applications
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Genomics, phytochemicals, and oxidative stress
- Virus-based gene therapy research
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Toxoplasma gondii Research Studies
- Air Quality and Health Impacts
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neonatal Respiratory Health Research
- Vector-borne infectious diseases
- Medical and Biological Ozone Research
- Heavy Metal Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Heme Oxygenase-1 and Carbon Monoxide
- Circadian rhythm and melatonin
- Energy and Environment Impacts
- Selenium in Biological Systems
- Intestinal Malrotation and Obstruction Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Parkinson's Disease Mechanisms and Treatments
- Nerve injury and regeneration
- Cytomegalovirus and herpesvirus research
- Climate Change and Health Impacts
Universidad de Guadalajara
2012-2024
Millions of people around the world are exposed to air pollutants, such as particulate matter 2.5 (PM2.5) and ozone (O3). Such exposure usually does not exclude these two types pollutants their harmful effects could be additive or synergistic. O3 is a highly oxidizing gas that reacts with cellular environment just PM2.5, triggering nitrooxidative damage. Once stress overcomes endogenous antioxidant system, an acute neuroinflammatory process generated, once it becomes chronic, favors...
Giardia lamblia is a worldwide protozoan responsible for significant number of intestinal infections. There are several drugs the treatment giardiasis, but they often cause side effects. Curcumin, component turmeric, has antigiardial activity; however, molecular target and mechanism antiproliferative activity not clear. The effects curcumin on cellular microtubules have been widely investigated. Since tubulin most abundant protein in cytoskeleton Giardia, to elucidate whether against this...
One of the main concerns regarding organophosphate pesticides (OP) is their possible toxic effects. Doses that do not produce acute toxicity are capable altering structure and biochemistry different tissues organs by production reactive oxygen species (ROS). Curcumin (CUR) substance in Curcuma longa (Zingiberacea) rhizome has strong antioxidant activity. However, neuroprotective properties curcumin against oxidative stress induced prolonged exposure to parathion (PAR) clear.The present work...
Ozone is a harmful tropospheric pollutant, causing the formation of reactive oxygen and nitrogen species that lead to oxidative damage in living beings. NF‐ κ B can be activated response damage, inducing an inflammatory response. Nowadays, there are no reliable results consolidate use antioxidants protect from caused by ozone, particularly highly polluted cities. Curcumin has strong antioxidant activity potent inhibitor activation with side effects. The aim this study evaluate effect...
Ozone is the most oxidant tropospheric pollutant gas, causing damage through formation of reactive oxygen and nitrogen species. Reactive species induce nuclear factor-kappa B (NF-κB) activation leading to neuroinflammation characterized by astrocytosis, microgliosis, apoptotic cell death. There interest in evaluating pharmacological activity natural antioxidants confer neuroprotection against caused ozone highly polluted cities. Curcumin has been proven exert a protective action central...
Ozone (O3) is an oxidating tropospheric pollutant. When O3 interacts with biological substrates, reactive oxygen and nitrogen species (RONS) are formed. Severe oxidative damage exhausts the endogenous antioxidant system, which leads to decreased activity of enzymes such as catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD). Curcumin (CUR) a natural polyphenol well-documented anti-inflammatory properties. The aim this work evaluate effects curcumin on CAT, GPx, SOD...
Abstract Objectives This study was undertaken to investigate the amoebicidal potential of curcumin on Entamoeba histolytica, as well its synergistic effect with metronidazole. Methods histolytica trophozoites were exposed 100, 200 and 300 μm curcumin, for 6, 12 24 h. Consequently, viability cells determined by trypan blue exclusion test. All specimens further analysed scanning electron microscopy. For drug combination experiment, Chou-Talalay method used. Key findings Curcumin affected...
Chronic obstructive pulmonary disease (COPD) is comprised of histopathological alterations such as emphysema and peribronchial fibrosis. Matrix metalloproteinase 9 (MMP-9) one the key enzymes involved in both types tissue remodeling during development lung damage. In recent studies, it was demonstrated that deflamin, a protein component extracted from Lupinus albus, markedly inhibits catalytic activity MMP-9 experimental models colon adenocarcinoma ulcerative colitis. Therefore, present...
Pig paramyxovirus of the blue eye disease (PPBED) is a novel member paramyxoviridac family which infects pigs. In neonatal pigs it causes neurological damage, whereas in adult affects reproductive function. As PPBED damages new-born pig central nervous system (CNS), important to study whether binds membrane proteins all brain tissue, or selectively neuronal tissue stem, olfactory bulb, hippocampus, cerebellum, frontal, temporal and parietal cortex. It also establish neurones obtained from...
Neurodegeneration is the consequence of harmful events affecting nervous system that lead to neuronal death. Toxic substances, including air pollutants, are capable inducing neurodegeneration. Ozone (O3) most oxidative toxic pollutant. O3 reacts with cellular components and forms reactive oxygen nitrogen species, triggering nitro-oxidative damage during short-term exposure. Curcumin (CUR) a natural phenolic molecule bearing well-documented antioxidant anti-inflammatory biological activities...
The pig paramyxovirus of blue eye disease (PPBED) produces central nervous system (CNS) damage leading to death in piglets. However, when PPBED was injected into the muscle and came contact with hind limb peripheral nerves transported CNS, it did not cause could be a mechanism by which induce protection. This study analyses whether causes electrophysiological morphological alterations infected nerves. It also studies, induces onset haemagglutination inhibitory antibodies (HIA) is spinal cord...
The pig paramyxovirus of blue eye disease (PPBED) produces central nervous system (CNS) damage leading to death in piglets. However, when PPBED was injected into the muscle and came contact with hind limb peripheral nerves transported CNS, it did not cause could be a mechanism by which induce protection. This study analyses whether causes electrophysiological morphological alterations infected nerves. It also studies, induces onset haemagglutination inhibitory antibodies (HIA) is spinal cord...
Pig paramyxovirus of the blue eye disease (PPBED) is a novel member paramyxoviridae family which infects pigs. In neonatal pigs it causes neurological damage, whereas in adult affects reproductive function. As PPBED damages new‐born pig central nervous system (CNS), important to study whether binds membrane proteins all brain tissue, or selectively neuronal tissue stem, olfactory bulb, hippocampus, cerebellum, frontal, temporal and parietal cortex. It also establish neurones obtained from...