A5093689785- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical and Biological Ozone Research
- Occupational and environmental lung diseases
- Neonatal Respiratory Health Research
Universidad de Guadalajara
2024
The aim of this review is to update and synthesize the molecular mechanisms that lead heterogeneous effect on tissue remodeling observed in two most important clinical phenotypes chronic obstructive pulmonary disease (COPD), emphysema (PE) bronchitis (CB). Clinical experimental evidence suggests response promote PE, CB, or both, related differentiated genetic, epigenetic, conditions. Specifically, a tendency toward PE could be variant
Chronic obstructive pulmonary disease (COPD) is comprised of histopathological alterations such as emphysema and peribronchial fibrosis. Matrix metalloproteinase 9 (MMP-9) one the key enzymes involved in both types tissue remodeling during development lung damage. In recent studies, it was demonstrated that deflamin, a protein component extracted from Lupinus albus, markedly inhibits catalytic activity MMP-9 experimental models colon adenocarcinoma ulcerative colitis. Therefore, present...