A5014978237- Mosquito-borne diseases and control
- Monoclonal and Polyclonal Antibodies Research
- Immune responses and vaccinations
- Tuberculosis Research and Epidemiology
- Gut microbiota and health
- Glycosylation and Glycoproteins Research
- Infant Nutrition and Health
- COVID-19 Impact on Reproduction
- Nanoparticle-Based Drug Delivery
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- HIV Research and Treatment
- Receptor Mechanisms and Signaling
- Virology and Viral Diseases
- Advanced biosensing and bioanalysis techniques
- vaccines and immunoinformatics approaches
Universidad Nacional Autónoma de México
2025
Secretaría de Salud de Jalisco
2020-2024
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco
2020-2024
Pharmaceutical Biotechnology (Czechia)
2020-2022
Glioblastoma is the most common and highly malignant brain tumor in adults. New targeted therapeutic approaches are imperative. EGFRvIII has appealing targets using monoclonal antibodies. Thus, endeavors toward developing new mAbs therapies for GBM capable of targeting biomarker must prevail to improve patient’s prognosis. Here, we isolated characterized an anti-EGFRvIII vNAR from a non-immune freshwater stingray mixed library, termed R426. The R426 pEGFRvIII interaction was demonstrated by...
Abstract Immunotherapies based on antibody fragments have been developed and applied to human diseases, describing novel formats. The vNAR domains a potential therapeutic use related their unique properties. This work used non-immunized Heterodontus francisci shark library obtain with recognition of TGF-β isoforms. isolated T1 selected by phage display demonstrated binding the isoforms (-β1, -β2, -β3) direct ELISA assay. These results are supported using for first time Single-Cycle kinetics...
Mycobacterium tuberculosis and M. smegmatis form drug-tolerant biofilms through dedicated genetic programs. In support of a stepwise process regulating biofilm production in mycobacteria, it was shown elsewhere that lsr2 participates intercellular aggregation, while groEL1 required for maturation smegmatis. Here, by means RNA-Seq, we monitored the early steps bovis BCG, to distinguish aggregation from attachment surface. Genes encoding transcriptional regulators dosR BCG0114 (Rv0081) were...
Bacille Calmette-Guérin (BCG) remains the only licensed vaccine against tuberculosis (TB). While BCG protects TB in children, its protection pulmonary adults is suboptimal, and development of a better global health priority. Previously, we reported two recombinant strains effective murine with low virulence lung pathology immunocompromised mice guinea pigs. We have recently combined these into one novel candidate (BCGΔBCG1419c::ESAT6-PE25SS) evaluated immunogenicity, efficacy safety profile...
Abstract Dengue is a viral disease caused by any of the four distinct dengue virus (DENV) serotypes that circulate in many parts world. DENV now co-circulates with Zika and Chikungunya viruses (ZIKV CHIKV) regions Americas. Having this mind, plus fact clinical diagnosis persists as difficult task, due to similarity symptoms, well false-positive results cross-reactivity IgG IgM against these three viruses, correct identification at an early stage essential minimise transmission prevent...