A5054022851- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Tuberculosis Research and Epidemiology
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Biochemical and Structural Characterization
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Mast cells and histamine
- Biosimilars and Bioanalytical Methods
- Polyamine Metabolism and Applications
- Viral Infections and Outbreaks Research
- CAR-T cell therapy research
- HIV Research and Treatment
- Research on Leishmaniasis Studies
- Transgenic Plants and Applications
Instituto Conmemorativo Gorgas de Estudios de la Salud
2019-2022
Universidad de la República
2019-2022
Secretaría de Salud de Jalisco
2012-2013
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco
2012-2013
The alphaviruses Chikungunya (CHIKV), Mayaro (MAYV), Una (UNAV), and the flavivirus Zika (ZIKV) are emerging or re-emerging arboviruses which responsible for frequent epidemic outbreaks. Despite large impact of these on health systems, there no approved vaccines treatments to fight infections. As a consequence, is an urgent need discover new antiviral drugs. Natural products rich source compounds with distinct biological activities, including properties. Thus, we aimed explore potential...
Mayaro (MAYV) and Una (UNAV) are emerging arboviruses belonging to the Alphavirus genus of Togaviridae family. These viruses can produce febrile disease with symptoms such as fever, headache, myalgia, skin rash incapacitating poly-arthralgia. Serological studies indicate that both circulating in different countries Latin America. Viruses need host cell machinery resources replicate effectively. One strategy find new antivirals consists identifying key cellular pathways or factors essential...
Active hypusine-modified initiation elongation factor 5A is critical for cell proliferation and differentiation, embryonic development, innate immune response of macrophages to bacterial infection. Here, we demonstrate that both virus infection double-stranded RNA viral mimic stimulation induce the hypusination eIF5A. Furthermore, show activation eIF5A essential replication several viruses including influenza A virus, vesicular stomatitis chikungunya mayaro una zika punta toro virus....
Mayaro virus (MAYV) hijacks the host’s cell machinery to effectively replicate. The mitogen-activated protein kinases (MAPKs) p38, JNK, and ERK1/2 have emerged as crucial cellular factors implicated in different stages of viral cycle. However, whether MAYV uses these MAPKs competently replicate has not yet been determined. aim this study was evaluate impact MAPK inhibition on replication using primary human dermal fibroblasts (HDFs) HeLa cells. Viral yields supernatants from MAYV-infected...
Tuberculosis causes close to 1.5 million deaths in the world, with new cases exceeding 9 recent years. Coinfection HIV further worsens global situation. New molecules that overcome limitations of currently used drugs are needed. We aimed determine whether HHC-10 is active against Mycobacterium tuberculosis complex bacteria bovis bacille calmette guerin (BCG) vitro and vivo. For this, was tested using different peptide concentrations, vivo, C57BL/6 mice infected intratracheally, at two doses...
Mayaro virus (MAYV) hijacks the host´s cell machinery to effectively replicate. The mitogen-activated protein kinases (MAPKs) p38, JNK and ERK1/2 have emerged as crucial cellular factors implicated in different stages of viral cycle. However, whether MAYV uses these MAPKs competently replicate has not yet been determined. aim this study was evaluate impact inhibition on replication using primary human dermal fibroblasts (HDFs) HeLa cells. Viral yields supernatants from...