Houri Hintiryan
A5081133991- Neural dynamics and brain function
- Cell Image Analysis Techniques
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Single-cell and spatial transcriptomics
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Photoreceptor and optogenetics research
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Neuroimaging Techniques and Applications
- Circadian rhythm and melatonin
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Nasal Surgery and Airway Studies
- Bioinformatics and Genomic Networks
- Advanced Fluorescence Microscopy Techniques
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Visual perception and processing mechanisms
- EEG and Brain-Computer Interfaces
University of California, Los Angeles
2011-2023
University of Southern California
2004-2021
Southern California University for Professional Studies
2009
The cortico-basal ganglia-thalamo-cortical loop is one of the fundamental network motifs in brain. Revealing its structural and functional organization critical to understanding cognition, sensorimotor behaviour, natural history many neurological neuropsychiatric disorders. Classically, this conceptualized contain three information channels: motor, limbic associative1-4. Yet three-channel view cannot explain myriad functions basal ganglia. We previously subdivided dorsal striatum into 29...
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated interpreted
Abstract The paraventricular nucleus of the hypothalamus (PVH) plays a critical role in regulation autonomic, neuroendocrine, and behavioral activities. This understanding has come from extensive characterization PVH rats, for this mammalian species we now have robust model basic neuroanatomy function. However, mice, whose use as research animal burgeoned with increasing sophistication tools genetic manipulation, comparable level not been achieved. To address this, employed variety...
The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of cognitive sensorimotor behaviors. However, it remains unclear how descending input arising from higher-order associative areas coordinate with SC networks influence its outputs. Here, we construct comprehensive map all cortico-tectal projections identify four collicular zones differential inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl) lateral (SC.l). Further, delineate the...
The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile projection neurons inform granular, type-specific interrogations warranted. Here, we apply machine-learning based computational informatics analysis techniques results circuit-tracing experiments create foundational,...
Characterizing cellular diversity at different levels of biological organization and across data modalities is a prerequisite to understanding the function cell types in brain. Classification neurons also essential manipulate controlled ways understand their variation vulnerability brain disorders. The BRAIN Initiative Cell Census Network (BICCN) an integrated network data-generating centers, archives, standards developers, with goal systematic multimodal type profiling characterization....
Abstract Characterizing the precise three-dimensional morphology and anatomical context of neurons is crucial for neuronal cell type classification circuitry mapping. Recent advances in tissue clearing techniques microscopy make it possible to obtain image stacks intact, interweaving neuron clusters brain tissues. As most current 3D reconstruction methods are only applicable single neurons, remains challenging reconstruct these digitally. To advance state art beyond challenges, we propose a...
We introduce the first open resource for mouse olfactory connectivity data produced as part of Mouse Connectome Project (MCP) at UCLA. The MCP aims to assemble a whole-brain atlas C57Bl/6J using double coinjection tracing method. Each consists one anterograde and retrograde tracer, which affords advantage simultaneously identifying efferent afferent pathways directly reciprocal injection sites. systematic application coinjections potentially reveals interaction stations between injections...
Abstract An essential step toward understanding brain function is to establish a cellular-resolution structural framework upon which multi-scale and multi-modal information spanning molecules, cells, circuits systems can be integrated interpreted. Here, through collaborative effort from the Brain Initiative Cell Census Network (BICCN), we derive comprehensive cell type-based description of one structure - primary motor cortex upper limb area (MOp-ul) mouse. Applying state-of-the-art...
ABSTRACT We report the generation of a multimodal cell census and atlas mammalian primary motor cortex (MOp or M1) as initial product BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved morphological electrophysiological properties, cellular resolution input-output mapping, integrated through cross-modal computational analysis. Together, our results advance...
Abstract Here we present a flatmap of the mouse central nervous system (CNS) (brain) and substantially enhanced flatmaps rat human brain. Also included are representations white matter tracts, ganglia, nerves, an series 10 showing different stages brain development. The adult provide layered diagrammatic representation CNS divisions, according to their arrangement in corresponding reference atlases: Brain Maps 4.0 (BM4, rat) (Swanson, Journal Comparative Neurology, 2018, 526, 935–943), first...
ABSTRACT The cortico-basal ganglia-thalamic loop is one of the fundamental network motifs in brain. Revealing its structural and functional organization critical to understanding cognition, sensorimotor behavior, natural history many neurological neuropsychiatric diseases. Classically, basal ganglia conceptualized contain three primary information output channels: motor, limbic, associative. However, given roughly 65 cortical areas two dozen thalamic nuclei that feed into dorsal striatum, a...
We describe a novel neuroinformatic platform, the BAMS2 Workspace (http://brancusi1.usc.edu), designed for storing and processing information on gray matter region axonal connections. This de novo constructed module allows registered users to collate their data directly by using simple versatile visual interface. It also construction analysis of sets connections associated with nomenclatures from any designated species. The includes set tools allowing display in matrix networks formats...
The subiculum is the major output component of hippocampal formation and one brain structures most affected by Alzheimer's disease. Our previous work revealed a hidden laminar architecture within mouse subiculum. However, rotation longitudinal axis across species makes it unclear how organization represented in human Using situ hybridization data from Allen Human Brain Atlas, we demonstrate that also contains complementary gene expression patterns similar to mouse. In addition, provide...
Abstract The macroscale neuronal connections of the lateral preoptic area (LPO) and caudally adjacent hypothalamic anterior region (LHAa) were investigated in mice by anterograde retrograde axonal tracing. Both regions are highly diversely connected, with to >200 gray matter spanning forebrain, midbrain, rhombicbrain. Intrahypothalamic predominate, followed cerebral cortex nuclei. A similar overall pattern LPO LHAa contrasts substantial differences between their input output connections....
Abstract Characterizing cellular diversity at different levels of biological organization across data modalities is a prerequisite to understanding the function cell types in brain. Classification neurons also required manipulate controlled ways, and understand their variation vulnerability brain disorders. The BRAIN Initiative Cell Census Network (BICCN) an integrated network generating centers, archives standards developers, with goal systematic multimodal type profiling characterization....
Abstract A composite confocal photomicrograph showing the organization an topographic relations of specific neuronal populations in hypothalamic paraventricular nucleus (PVH) a C57BL/6malemouse. One population PVH neurons (presumptive neuroendocrine) was identified by immunocytochemical detection retrograde tracer Fluorogold (FG; green) following its injection to tail vein; second preautonomic) back‐labeled upper thoracic level spinal cord Fast Blue (FB; blue). Subsequently, distinct...
ABSTRACT The basolateral amygdalar complex (BLA) is implicated in behavioral processing ranging from fear acquisition to addiction. Newer methods like optogenetics have enabled the association of circuit-specific functionality uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile projection neurons inform granular, type-specific interrogations warranted. In this work, we applied computational analysis techniques results our circuit-tracing experiments create...
Taste reactivity testing (TRT), which entails infusing a solution into the oral cavity of subjects, is used across wide range studies. For laboratories inexperienced in conventional technique implanting cheek fistulae, surgery can be problematic for both subjects and experimenter. We have proposed refined method fistulae implantation that less invasive, thereby reducing pain distress animals. Using this technique, we were able to replicate findings previous TRT studies, namely high dose...
The present series of experiments challenges the ability hormone estradiol to act as an unconditioned stimulus in conditioned taste avoidance (CTA) learning paradigm. We hypothesize that reductions sucrose consumption observed after pairing it with are not indicative associative learning, but due expression estradiol's anorectic effects during time CTA assessment. Three which a solution was paired were conducted test this hypothesis. Experiment 1 demonstrated female rats expressed reduction...