Jason Palmer
A5101406847- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Neural dynamics and brain function
- Advanced Fluorescence Microscopy Techniques
- Brain Tumor Detection and Classification
- Neural Networks and Applications
Cold Spring Harbor Laboratory
2020-2023
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated interpreted
Abstract An essential step toward understanding brain function is to establish a cellular-resolution structural framework upon which multi-scale and multi-modal information spanning molecules, cells, circuits systems can be integrated interpreted. Here, through collaborative effort from the Brain Initiative Cell Census Network (BICCN), we derive comprehensive cell type-based description of one structure - primary motor cortex upper limb area (MOp-ul) mouse. Applying state-of-the-art...
Abstract Brain research is an area of characterized by its cutting-edge nature, with brain mapping constituting a crucial aspect this field. As sequencing tools have played role in gene sequencing, largely depends on automated, high-throughput and high-resolution imaging techniques. Over the years, demand for has scaled exponentially rapid development microscopic mapping. In paper, we introduce novel concept confocal Airy beam into oblique light-sheet tomography named CAB-OLST. We...
Cell-type composition across brain regions is a critical structural factor shaping both local and long-range circuits. Here, we employed single-cell resolution imaging of the mouse brain, combined with computational analyses, to map distribution 30 cell classes types defined by gene marker expression in Cre recombinase-based genetic models. This approach generated comprehensive atlas type-specific densities male female revealing (1) surprisingly broad sex differences cells tagged...