Laura Korobkova
A5057217149- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Hearing, Cochlea, Tinnitus, Genetics
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Cell Image Analysis Techniques
- Neurogenesis and neuroplasticity mechanisms
- Single-cell and spatial transcriptomics
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Migration, Health and Trauma
- Health and Conflict Studies
- Viral Infections and Vectors
- Qualitative Research Methods and Ethics
- Child Welfare and Adoption
- Visual perception and processing mechanisms
- COVID-19 Impact on Reproduction
- Extracellular vesicles in disease
- Advanced MRI Techniques and Applications
- Child Abuse and Trauma
- Axon Guidance and Neuronal Signaling
- Biochemical Analysis and Sensing Techniques
University of Southern California
2019-2025
The cortico-basal ganglia-thalamo-cortical loop is one of the fundamental network motifs in brain. Revealing its structural and functional organization critical to understanding cognition, sensorimotor behaviour, natural history many neurological neuropsychiatric disorders. Classically, this conceptualized contain three information channels: motor, limbic associative1-4. Yet three-channel view cannot explain myriad functions basal ganglia. We previously subdivided dorsal striatum into 29...
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated interpreted
The superior colliculus (SC) receives diverse and robust cortical inputs to drive a range of cognitive sensorimotor behaviors. However, it remains unclear how descending input arising from higher-order associative areas coordinate with SC networks influence its outputs. Here, we construct comprehensive map all cortico-tectal projections identify four collicular zones differential inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl) lateral (SC.l). Further, delineate the...
The basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile projection neurons inform granular, type-specific interrogations warranted. Here, we apply machine-learning based computational informatics analysis techniques results circuit-tracing experiments create foundational,...
Abstract An essential step toward understanding brain function is to establish a cellular-resolution structural framework upon which multi-scale and multi-modal information spanning molecules, cells, circuits systems can be integrated interpreted. Here, through collaborative effort from the Brain Initiative Cell Census Network (BICCN), we derive comprehensive cell type-based description of one structure - primary motor cortex upper limb area (MOp-ul) mouse. Applying state-of-the-art...
ABSTRACT The cortico-basal ganglia-thalamic loop is one of the fundamental network motifs in brain. Revealing its structural and functional organization critical to understanding cognition, sensorimotor behavior, natural history many neurological neuropsychiatric diseases. Classically, basal ganglia conceptualized contain three primary information output channels: motor, limbic, associative. However, given roughly 65 cortical areas two dozen thalamic nuclei that feed into dorsal striatum, a...
The subiculum is the major output component of hippocampal formation and one brain structures most affected by Alzheimer's disease. Our previous work revealed a hidden laminar architecture within mouse subiculum. However, rotation longitudinal axis across species makes it unclear how organization represented in human Using situ hybridization data from Allen Human Brain Atlas, we demonstrate that also contains complementary gene expression patterns similar to mouse. In addition, provide...
The dentate gyrus (DG) is an integral portion of the hippocampal formation, and it composed three layers. Quantitative magnetic resonance (MR) imaging has capability to map brain tissue microstructural properties which can be exploited investigate neurodegeneration in Alzheimer's disease (AD). However, assessing subtle pathological changes within layers requires high resolution histological validation. In this study, we utilized a 16.4 Tesla scanner acquire ex vivo multi-parameter...
ABSTRACT The basolateral amygdalar complex (BLA) is implicated in behavioral processing ranging from fear acquisition to addiction. Newer methods like optogenetics have enabled the association of circuit-specific functionality uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile projection neurons inform granular, type-specific interrogations warranted. In this work, we applied computational analysis techniques results our circuit-tracing experiments create...
SUMMARY The superior colliculus (SC) is a midbrain structure that receives diverse and robust cortical inputs to drive range of cognitive sensorimotor behaviors. However, it remains unclear how descending arising from higher-order associative areas coordinate with SC networks influence its outputs. In this study, we constructed comprehensive map all cortico-tectal projections identified four collicular zones differential inputs: medial (SC.m), centromedial (SC.cm), centrolateral (SC.cl)...
Echoes of natural and anthropogenic traumas not only reverberate within the physiology, biology, neurobiology generation directly exposed to them but also biology future generations. With intent understanding this phenomenon, significant efforts have sought establish multi-generational legacies experiences like stress, chemical exposures, nutritional impoverishment, chemosensory experiences. From these studies, we are gaining new appreciation for how trauma come be bequeathed This review...
Summary The subiculum is the major output structure of hippocampal formation and one brain regions most affected by Alzheimer’s disease. Our previous work revealed a hidden laminar architecture within mouse subiculum. However, rotation longitudinal axis across species makes it unclear how organization represented in human Using situ hybridization data from Allen Human Brain Atlas, we demonstrate that also contains complementary gene expression patterns similar to mouse. In addition, provide...
Exposure to early life adversity (ELA), including childhood maltreatment, is one of the most significant risk factors for emergence neuropsychiatric disorders in adolescence and adulthood. Despite this relationship being well established, underlying mechanisms remain unclear. One way achieve understanding identify molecular pathways processes that are perturbed as a consequence maltreatment. Ideally, these perturbations would be evident changes DNA, RNA or protein profiles easily accessible...
Abstract Analyzing Alzheimer’s disease (AD) pathology within anatomical subregions is a significant challenge, often carried out by pathologists using standardized, semi-quantitative approach. To augment traditional methods, high-throughput, high-resolution pipeline was created to classify the distribution of AD hippocampal subregions. USC ADRC post-mortem tissue sections from 51 patients were stained with 4G8 for amyloid, Gallyas neurofibrillary tangles (NFTs) and Iba1 microglia. Machine...
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative that affects all components of the neurovascular unit. The hallmark pathology AD, amyloid plaques and tau neurofibrillary tangles, aggregate within gray matter areas spread across neural networks. Although AD scarce white brain regions, abnormalities have been observed in patients using diffusion tensor imaging (DTI; Sachdev et al 2013) tracts are putative therapeutic targets for deep stimulation (Lam 2020)....
Abstract Background Alzheimer’s disease (AD) is a complex neurodegenerative characterized by progressive amyloid and tau pathology. Quantifying classifying AD pathology across the human brain challenging due to its large size expertise needed for critical evaluation of morphological variety in structure types (e.g. diffuse vs dense plaques, neurofibrillary tangles, neuropil threads, etc.). High‐throughput microscopy imaging artificial intelligence allow large‐scale, quantitative ‘digital...