Cristina Muscio
A5080506625- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Functional Brain Connectivity Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Neurological Disease Mechanisms and Treatments
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Biomedical Text Mining and Ontologies
- Parkinson's Disease Mechanisms and Treatments
- Topic Modeling
- Neurological and metabolic disorders
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Neurological Disorders and Treatments
- Artificial Intelligence in Healthcare
- Brain Tumor Detection and Classification
- Neuroscience and Music Perception
- Attention Deficit Hyperactivity Disorder
- Delphi Technique in Research
- Natural Language Processing Techniques
- Medical Image Segmentation Techniques
Azienda Socio Sanitaria Territoriale Lariana
2022-2025
Fondazione IRCCS Istituto Neurologico Carlo Besta
2016-2024
Azienda Socio Sanitaria Territoriale di Bergamo Ovest
2022-2024
University of Bergamo
2023-2024
Azienda Ospedaliera Treviglio
2022-2023
Centro San Giovanni di Dio Fatebenefratelli
2013-2022
Vita-Salute San Raffaele University
2022
Istituto Universitario di Studi Superiori di Pavia
2022
University of Geneva
2022
Fondazione Santa Lucia
2022
Three sets of research criteria are available for diagnosis Alzheimer's disease in subjects with mild cognitive impairment: the International Working Group-1, Group-2, and National Institute Aging-Alzheimer Association criteria. We compared prevalence prognosis at impairment stage according to these Subjects (n = 1607), 766 whom had both amyloid neuronal injury markers, were recruited from 13 cohorts. used test performance biomarkers classify as prodromal Group-1 Group-2 high likelihood...
<h3>Importance</h3> Cerebral amyloidosis is a key abnormality in Alzheimer disease (AD) and can be detected vivo with positron emission tomography (PET) ligands. Although amyloid PET has clearly demonstrated analytical validity, its clinical utility debated. <h3>Objective</h3> To evaluate the incremental diagnostic value of florbetapir F 18 addition to routine assessment patients evaluated for cognitive impairment. <h3>Design, Setting, Participants</h3> The Incremental Diagnostic Value...
In this study, we compared the effects promoted by a brief single session of crochet in group skilled knitters (CRO) and control (CRT) on Attentional Network Test (ANT) whole brain Functional Connectivity (FC) revealed Magnetoencephalography (MEG). Data that determined significant effect (before, T0, vs after, T1, session) reaction times (for all cue stimulus types), improving alertness orienting networks (but not executive control) only CRO group. FC are coherent with behavioural ones. We...
Objective To compare the diagnostic value of striatal 123 I‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)‐ N ‐(3‐fluoropropyl) nortropane ( I‐FP‐CIT) single photon emission computed tomography (SPECT) and I‐metaiodobenzylguanidine I‐MIBG) myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from other types. Methods This prospective longitudinal study included 30 patients a clinical diagnosis DLB 29 non‐DLB (Alzheimer disease, n = 16; behavioral variant frontotemporal dementia,...
Lombardy was severely hit by the COVID-19 pandemic since February 2020 and Health System underwent rapid reorganization. Outpatient clinics were stopped for non-urgent patients: it became a priority to manage hundreds of fragile neurological patients who suddenly had less reference points. In Italy, before pandemic, Televisits neither recognized nor priced. At Fondazione IRCCS Istituto Neurologico C. Besta, we reorganized outpatient deliver Neuro-telemedicine services, including...
Biomarker-based differential diagnosis of the most common forms dementia is becoming increasingly important. Machine learning (ML) may be able to address this challenge. The aim study was develop and interpret a ML algorithm capable differentiating Alzheimer's dementia, frontotemporal with Lewy bodies cognitively normal control subjects based on sociodemographic, clinical, magnetic resonance imaging (MRI) variables. 506 from 5 databases were included. MRI images processed FreeSurfer, LPA,...
Background and purpose Biomarkers support the aetiological diagnosis of neurocognitive disorders in vivo . Incomplete evidence is available to drive clinical decisions; diagnostic algorithms are generic not very helpful practice. The aim was develop a biomarker‐based algorithm for mild cognitive impairment patients, leveraging on knowledge from recognized national experts. Methods With Delphi procedure, experienced clinicians making variable use biomarkers practice representing five Italian...
This was a multicenter study aimed at investigating the characteristics of cognitive decline, neuropsychiatric symptoms, and brain imaging in individuals with subjective decline (SCD) subtle (pre-mild impairment [pre-MCI]).Data were obtained from Network-AD project (NET-2011-02346784). The included participants underwent baseline neurobehavioral evaluation, FDG-PET, amyloid PET. We used principal component analysis (PCA) to identify independent neuropsychological dimensions their association...
The reference standard for spatial normalization of brain positron emission tomography (PET) images involves structural Magnetic Resonance Imaging (MRI) data. However, the lack such information is fairly common in clinical settings. This might lead to proper image quantification and evaluation based only on visual ratings, which does not allow research studies or trials quantification. PET/CT systems are widely available CT procedures need be explored. Here we describe validate a procedure...
A 40-y-old woman with severe acute respiratory syndrome coronavirus 2 infection developed neurologic manifestations (confusion, agitation, seizures, dyskinesias, and parkinsonism) a few weeks after the onset of syndrome. MRI cerebrospinal fluid analyses were unremarkable, but <sup>18</sup>F-FDG PET/CT showed limbic extralimbic hypermetabolism. full recovery, alongside normalization in previously hypermetabolic areas, was observed intravenous immunoglobulin administration.
Abstract Introduction We test the hypothesis that amyloid–positron emission tomography prescriptions, considered appropriate based on Amyloid Imaging Taskforce (AIT) criteria, lead to greater clinical utility than AIT‐inappropriate prescriptions. Methods compared between patients who underwent appropriately or inappropriately and among subgroups of defined by AIT criteria. Finally, we performed logistic regressions identify variables associated with utility. Results identified 171...
ORIGINAL RESEARCH article Front. Neurol., 23 September 2020Sec. Dementia and Neurodegenerative Diseases Volume 11 - 2020 | https://doi.org/10.3389/fneur.2020.01021
OPINION article Front. Aging Neurosci., 11 March 2015Sec. Neurocognitive and Behavior Volume 7 - 2015 | https://doi.org/10.3389/fnagi.2015.00026
Abstract Accurate and reproducible automated segmentation of human hippocampal subfields is interest to study their roles in cognitive functions disease processes. Multispectral structural MRI methods have been proposed improve subfield accuracy, but the reproducibility a multicentric setting is, date, not well characterized. Here, we assessed test–retest FreeSurfer 6.0 segmentations using multispectral analysis pipelines (22 healthy subjects scanned twice, week apart, at four 3T sites). The...
Abstract Background Neuropsychological testing plays a cardinal role in the diagnosis and monitoring of Alzheimer’s disease. A major concern is represented by heterogeneity neuropsychological batteries currently adopted memory clinics healthcare centers. The current study aimed to solve this issue. Methods Following initiative University Washington’s National Coordinating Center (NACC), we presented Italian adaptation Test Battery Uniform Data Set (I-UDSNB). We collected data from 433...
BACKGROUND Three different amyloid tracers labeled with 18-flourine have been introduced into clinical use. The leaflets of indicate visual criteria for PET reporting. In practice, it is not yet ascertained whether these are equivalent in terms diagnostic accuracy or if anyone better than another. We aimed to evaluate the inter and intra-rater variability assessment 18F-Florbetapir PET/CT images among six independent readers experience. METHODS analyzed 252 scans, visually assessed by each...
Beliefs of dementia experts about the pathogenic role amyloid in Alzheimer's disease (AD) may affect use positron emission tomography (PET).To assess attributed to AD pathogenesis by Italian experts, and whether this modulates impact PET results their diagnostic workup.22 rated beliefs amyloid. Then, we asked them rate probability change diagnosis based on result for 7 case vignettes, depicting patients who initially received a comprehensive workup later consistent or inconsistent with...
Abstract Background Neurodegenerative diseases lead to memory disorders and cognitive impairments with major impacts on day‐to‐day function. Early detection of patients is essential for an efficient care approach, differential diagnosis determining prognosis tailoring management. Most research studies compare by pairwise comparison methods, but this does not correspond daily clinical practice, in which clinicians need distinguish many different possible types dementia concomitantly. It has...
We describe a case of amyotrophic lateral sclerosis (ALS) associated with Alzheimer’s disease (AD) and review the literature about coexistence two entities, highlighting following: mean age at onset is 63.8 years, slight female predominance; ALS tends to manifest after cognitive impairment often begins in bulbar region; average duration 3 years; phenotype mostly amnestic; pattern brain involvement is, most cases, consistent AD. Our reviewed ones suggest that patients dementia lacking...