A5006854110- Migraine and Headache Studies
- Trigeminal Neuralgia and Treatments
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Amyotrophic Lateral Sclerosis Research
- Traumatic Brain Injury Research
- EEG and Brain-Computer Interfaces
- Pain Mechanisms and Treatments
- Engineering Technology and Methodologies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Healthcare Systems and Public Health
- Heart Rate Variability and Autonomic Control
- Musculoskeletal pain and rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurogenetic and Muscular Disorders Research
- Circadian rhythm and melatonin
- Parkinson's Disease Mechanisms and Treatments
- Mindfulness and Compassion Interventions
- Action Observation and Synchronization
- Neurological Disease Mechanisms and Treatments
Fondazione IRCCS Istituto Neurologico Carlo Besta
2019-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2022
Despite hypothalamus has long being considered to be involved in the pathophysiology of cluster headache, inconsistencies previous neuroimaging studies and a limited understanding hypothalamic areas involved, impede comprehensive interpretation its involvement this condition.
Abstract Background Mindfulness gained considerable attention for migraine management, but RCTs are lacking. We aimed to assess the efficacy of a six-sessions mindfulness-based treatment added as usual (TaU) in patients with Chronic Migraine (CM) and Medication Overuse Headache (MOH) on headache frequency, medication intake, quality life, disability, depression anxiety, cutaneous allodynia, awareness inner states, work-related difficulties, disease cost. Methods In this Phase-III...
Neuroimaging studies often lack reproducibility, one of the cardinal features scientific method. Multisite collaboration initiatives increase sample size and limit methodological flexibility, therefore providing foundation for increased statistical power generalizable results. However, multisite collaborative are inherently limited by hardware, software, pulse sequence design heterogeneities both clinical preclinical MRI scanners benchmark acquisition protocols, data analysis, sharing. We...
Magnetic Resonance-guided high-intensity Focused Ultrasound (MRgFUS) of the thalamic ventral intermediate nucleus (Vim) for tremor has increasingly gained interest as a new non-invasive alternative to standard neurosurgery. Resting state functional connectivity (rs-FC) correlates MRgFUS have not been extensively investigated yet. A region (ROI)-to-ROI rs-FC MRI "connectomic" analysis focusing on brain regions relevant was conducted 15 tremor-dominant patients with Parkinson's disease who...
Abstract Objective Spinal cord degeneration is a hallmark of amyotrophic lateral sclerosis. The assessment gray matter and white cervical spinal atrophy across clinical stages defined using the King's staging system could advance understanding sclerosis progression. Methods We assessed in vivo spatial pattern along (C2 to C6 segments) 2D phase‐sensitive inversion recovery imaging cohort 44 patients, evaluating its change correlation with disability scored by functional rating scale revised...
Biomarker-based differential diagnosis of the most common forms dementia is becoming increasingly important. Machine learning (ML) may be able to address this challenge. The aim study was develop and interpret a ML algorithm capable differentiating Alzheimer's dementia, frontotemporal with Lewy bodies cognitively normal control subjects based on sociodemographic, clinical, magnetic resonance imaging (MRI) variables. 506 from 5 databases were included. MRI images processed FreeSurfer, LPA,...
Abstract Objective In elderly people loneliness represents a risk factor for dementia and may negatively impact on mental physical health. The specific contribute of to cognitive behavioral functioning have not yet been determined in amyotrophic lateral sclerosis (ALS). Our hypothesis was that be related motor dysfunction with negative decline, possibly cortical involvement. Methods 200 ALS patients (ALSpts) 50 healthy controls (HCs) we measured loneliness, mood, quality life (QoL). ALSpts...
Converging evidence suggests that anatomical and functional mesocorticolimbic abnormalities support the chronicization of pain disorders.We mapped structural alterations system in a sample chronic cluster headache patients (n = 28) comparison to age sex-matched healthy individuals employing MRI resting-state MRI.Univariate logistic regression models showed several examined structures/areas (i.e., bilateral nucleus accumbens, ventral diencephalon, hippocampus, frontal pole, right amygdala)...
Objective The notion that cerebellar pathology may contribute to cognitive impairment in ALS, especially patients with C9orf72 repeated expansion, has been inconsistently reported. This study aimed exploring the relationship between involvement, and C9orf72repeated expansion of ALS. Methods Quantitative in-vivo assessment lobules investigated 66 non-demented ALS 28 healthy controls. Pathologic was found 13 patients. Mild and/or behavioral diagnosed 22 negative Measures cortical volume (CV)...
Abstract Background Magnetic resonance‐guided focused ultrasound (MRgFUS) targeting the thalamic ventral intermediate nucleus (VIM) is an innovative treatment for drug‐refractory essential tremor (ET). The relationship between lesion characteristics, dentate‐rubro‐thalamic‐tract (DRTT) involvement and clinical benefit remains unclear. Objectives To investigate whether outcome related to volume and/or its overlap with DRTT. compare reliability of probabilistic versus deterministic...
The impact of language impairment on the clinical assessment patients suffering from disorders consciousness (DOC) is unknown or underestimated and may mask presence conscious behavior. In a group DOC ( n = 11; time post-injury range: 5–252 months), we investigated main neural functional structural underpinnings linguistic processing, their relationship with behavioral measures auditory function using Coma Recovery Scale-Revised (CRS-R). We assessed integrity brainstem pathways, left...
Previous studies on brain morphological alterations in chronic cluster headache revealed inconsistent findings.The present cross-sectional explorative study determined telencephalic and cerebellar cortex thickness a relatively wide sample of patients (n = 28) comparing them to matched healthy individuals.The combination two highly robust state-of-the-art approaches for estimation (Freesurfer, CERES), strengthened by functional characterization the identified abnormal regions, four main...
Abstract In the past 2 decades, several attempts have been made to promote a correct diagnosis and possible restorative interventions in patients suffering from disorders of consciousness. Sensory stimulation has proved be useful sustaining level arousal/awareness improve behavioural responsiveness with significant effect on oro-motor functions. Recently, action observation proposed as strategy consciousness, based neurophysiological evidence that motor cortex can activated not only during...
Abstract Purpose Spinocerebellar ataxia SCA1 and SCA2 are adult-onset hereditary disorders, due to triplet CAG expansion in their respective causative genes. The pathophysiology of suggests alterations cerebello-thalamo-cortical pathway its connections the basal ganglia. In this framework, thalamic integrity is crucial for shaping efficient whole-brain dynamics functions. aims study identify structural changes nuclei presymptomatic symptomatic patients assess disease progression within a...
This article describes a case of Foreign accent syndrome (FAS) in an Italian woman who developed Canadian-like foreign without brain damage (functional FAS). The patient underwent in-depth neuroimaging and (neuro)psychological evaluation. Language networks the frontotemporal-parietal areas were typically activated bilaterally through fMRI MEG assessments based on task-based data. Resting-state showed preserved connectivity between language areas. An obsessive-compulsive personality profile...
Abstract Previous studies on brain morphological alterations in chronic cluster headache revealed inconsistent findings. The present cross-sectional explorative study determined telencephalic and cerebellar cortex thickness a relatively wide sample of patients (n=28) relation to matched healthy individuals. combination two highly robust state-of-the-art approaches for estimation (Freesurfer CERES) with an unbiased functional characterization the abnormal regions, main results. First, show...