A5105250482- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Palliative Care and End-of-Life Issues
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Alzheimer's disease research and treatments
- Healthcare professionals’ stress and burnout
- Ethics in medical practice
- Prion Diseases and Protein Misfolding
- Organ Transplantation Techniques and Outcomes
- Patient Dignity and Privacy
- Healthcare Decision-Making and Restraints
- Amyotrophic Lateral Sclerosis Research
- Aging, Elder Care, and Social Issues
- Trace Elements in Health
- Historical and Environmental Studies
- Organ Donation and Transplantation
- Ethics and Legal Issues in Pediatric Healthcare
- Mindfulness and Compassion Interventions
- Cognitive Functions and Memory
- Systemic Lupus Erythematosus Research
- Neurological and metabolic disorders
- Peripheral Neuropathies and Disorders
- Genomics and Rare Diseases
- Cerebrospinal fluid and hydrocephalus
Azienda Unita' Sanitaria Locale Di Modena
2025
Fondazione Europea Ricerca Biomedica
2008-2024
Aristotle University of Thessaloniki
2021
Vita-Salute San Raffaele University
2011
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2000-2004
<h3>Importance</h3> Cerebral amyloidosis is a key abnormality in Alzheimer disease (AD) and can be detected vivo with positron emission tomography (PET) ligands. Although amyloid PET has clearly demonstrated analytical validity, its clinical utility debated. <h3>Objective</h3> To evaluate the incremental diagnostic value of florbetapir F 18 addition to routine assessment patients evaluated for cognitive impairment. <h3>Design, Setting, Participants</h3> The Incremental Diagnostic Value...
The treatment of Alzheimer's disease (AD) in the field non-pharmacological interventions is a challenging issue, given limited benefits available drugs. Cognitive training (CT) represents commonly recommended strategy AD. Recently, repetitive transcranial magnetic stimulation (rTMS) has gained increasing attention as promising therapeutic tool for AD, its ability enhancing neuroplasticity. In present randomized, double-blind, sham-controlled study, we aimed at investigating add-on effect...
Informal care estimates for use in health-economic models are lacking. We aimed to estimate the association between informal time and dementia symptoms across Europe. A secondary analysis was performed on 13,529 observations 5,369 persons from 9 European pooled cohort or trial studies community-dwelling with dementia. mixed regression model fitted spent instrumental basic activities of daily living using disease severity demographic characteristics. Daily 0.5 hours higher moderate compared...
Early onset dementias (EOD) are rare neurodegenerative that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than late dementia.To identify known and/or novel variants major candidate genes associated to by high-throughput sequencing. Common-risk of apolipoprotein E (APOE) and prion protein (PRNP) were also assessed.We studied 22 recruited Memory Clinics, the context studies investigating genetic forms dementia. Two methodological...
Virtual reality can help individuals to manage stress and anxiety. In addition its efficacy in reducing anxiety through relaxation, virtual be helpful for psychoeducation. However, date, few studies have explored this topic. Therefore, mixed-methods sequential explanatory study, aimed investigate the usability, sense of presence, emotional response, effect on learning MIND-VR, a psychoeducational experience created offer information Twenty healthcare workers (60% female; mean age 43 ± 10)...
Abstract Forty consecutive patients with chronic sensorimotor polyneuropathy of undetermined cause were followed to determine disease progression and prognosis. They had neurological symptoms for at least 1 year before presentation. Neurophysiological examination in all showed axonal degeneration, which was confirmed by sural nerve biopsy. Patients reviewed every 3 months. Laboratory tests performed 6 months the first 2 years then annually. annually patients. up 4 years. In no instance a...
Background: Nursing home placement (NHP) can be the final step of patients with Alzheimer’s disease. Objective: We aimed to identify NHP predictors among 508 people dementia a 3-year follow-up. Methods: analyzed data from international observational RECage study, involving especially disease and comparing cohort enrolled by five centers Special Care Unit for BPSD (behavioral psychological symptoms dementia) another one six lacking this facility. The tertiary objective study was assess...
The use of thrombolytic therapy for acute ischemic stroke is still controversial. A major problem balancing the improvement in functional ability against risk early death from cerebral hemorrhage. Our aim was to assess whether patients who have had a stroke, and their proxies, would give consent thrombolysis if this were introduced into clinical practice Italy.A 10-item questionnaire administered by personnel not directly involved care 12 Italian hospitals. Interviews carried out with at...
Voting by persons with dementia raises questions about their decision-making capacity. Methods specifically addressing voting capacity of demented people have been proposed in the US, but never tested elsewhere. We translated and adapted US Competence Assessment Tool for (CAT-V) to Italian context, using it before 2006 elections Prime Minister. Consisting a brief questionnaire, this tool evaluates following abilities: understanding nature effect voting, expressing choice, reasoning choices....
OPINION article Front. Aging Neurosci., 11 March 2015Sec. Neurocognitive and Behavior Volume 7 - 2015 | https://doi.org/10.3389/fnagi.2015.00026
Background: Behavioral and psychological symptoms of dementia (BPSD) are quite challenging problems during the course. Special Care Units for people with (PwD) BPSD (SCU-B) residential medical structures, where patients temporarily admitted, in case unmanageable behavioral disturbances at home. Objective: RECage (REspectful Caring AGitated Elderly) aspires to assess short long-term effectiveness SCU-Bs toward alleviating improving quality life (QoL) PwD their caregivers. Methods: is a...
Background: Behavioral and psychological symptoms of dementia (BPSD) bring complexity in the clinical management people with dementia; therefore, it is important to evaluate different models care, such as Special Care Units (SCU-B).∥ Objective: To SCU-B effectiveness toward alleviating BPSD improving quality life (QoL) patients their caregivers.∥ Methods: ReCAGE was a multicenter, controlled, longitudinal study where 508 were enrolled two cohorts: 262 from centers endowed SCU-B, 246 without...
Virtual reality (VR) is helpful for the management of stress and anxiety. However, current interventions have limitations related to location (ie, therapist's office or hospitals) content virtual experiences only relaxation). This randomized pilot trial aims investigate efficacy acceptability a brief remote VR-based training supporting anxiety in sample Italian health care workers. A total 29 doctors nurses (n=21; 72% female; mean age 35.6, SD 10.3 years) were recruited VR intervention group...
One of the most widely used instruments for assessing agitation in dementia patients is Cohen-Mansfield Agitation Inventory (CMAI), nevertheless no global score has been proposed. The aim this study is: (a) to conduct a confirmatory (CFA) and exploratory factor analysis (EFA) CMAI on people with Psychological Behavioral Symptoms (BPSD), (b) propose an alternative structure, based clinical criteria including all items.Confirmatory analyses were carried out 29 items administered at baseline...