A5069807051- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurobiology of Language and Bilingualism
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Face Recognition and Perception
- Multiple Sclerosis Research Studies
- Facial Nerve Paralysis Treatment and Research
- Long-Term Effects of COVID-19
- Memory and Neural Mechanisms
- COVID-19 and Mental Health
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Transcranial Magnetic Stimulation Studies
- Autism Spectrum Disorder Research
- Language Development and Disorders
- Neural dynamics and brain function
- Reading and Literacy Development
- Chromium effects and bioremediation
- Neurogenesis and neuroplasticity mechanisms
- Cognitive Functions and Memory
- Cholinesterase and Neurodegenerative Diseases
Agostino Gemelli University Polyclinic
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Università Cattolica del Sacro Cuore
2012-2024
Sapienza University of Rome
2007-2022
University of the Sacred Heart
2010-2020
Conagra Brands (United States)
2020
Catholic University of America
2009-2015
University of Nebraska–Lincoln
2010-2014
Don Carlo Gnocchi Foundation
2013
Pontifícia Universidade Católica de São Paulo
2010
Metallic copper surfaces rapidly and efficiently kill bacteria. Cells exposed to accumulated large amounts of ions, this uptake was faster from dry than moist copper. suffered extensive membrane damage within minutes exposure Further, cells removed showed loss cell integrity. Acute contact with metallic did not result in increased mutation rates or DNA lesions. These findings are important first steps for revealing the molecular sensitive targets lethally challenged by provide a scientific...
In March 2020, the World Health Organization declared a global pandemic due to novel coronavirus SARS-CoV-2 and several governments planned national quarantine in order control virus spread. Acute psychological effects of frail elderly subjects with special needs, such as patients dementia, have been poorly investigated. The aim this study was assess modifications neuropsychiatric symptoms during dementia their caregivers.This is sub-study multicenter nation-wide survey. A structured...
Previous studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of COVID-19 in patients dementia are unknown. We investigated the clinical changes Alzheimer's disease other dementias, evaluated caregivers' distress during quarantine.
Recently, copper (Cu) in its metallic form has regained interest for antimicrobial properties. Use of Cu surfaces worldwide hospital trials resulted remarkable reductions surface contaminations. Yet, our understanding why microbes are killed upon contact to the metal is still limited and different modes action have been proposed. This knowledge, however, crucial sustained use such hospitals other hygiene-sensitive areas. Here, we report on molecular mechanisms by which Gram-positive...
The aim of this study was to investigate the neuronal network characteristics in physiological and pathological brain aging. A database 378 participants divided three groups analyzed: Alzheimer's disease (AD), mild cognitive impairment (MCI
ABSTRACT Surfaces made of copper or its alloys have strong antimicrobial properties against a wide variety microorganisms. However, the molecular mode action responsible for efficacy metallic is not known. Here, we show that dry surfaces inactivate Candida albicans and Saccharomyces cerevisiae within minutes in process called contact-mediated killing. Cellular ion homeostasis systems influenced kinetics killing both organisms. Deregulated uptake through hyperactive S. Ctr1p (ScCtr1p)...
Abstract Background: We report on a double‐blind, crossover pilot trial for the treatment of rapid eye movement behavior disorder (RBD) in 12 patients with Parkinson's disease whom conventional therapy failed. Methods: employed patch cholinesterase inhibitor rivastigmine at dose 4.6 mg/24 hours 3 weeks compared placebo to reduce frequency RBD episodes. The number episodes was monitored by diaries bed partners. Results: Rivastigmine well tolerated most patients, minor side effects, mainly...
Background: Family caregivers of patients with dementia are at high risk stress and burden, quarantine due to the coronavirus disease 2019 (COVID-19) pandemic may have increased psychological disturbances in this population. The current study was carried out during national lockdown declared March 2020 by Italian government as a containment measure first wave is nationwide survey on impact COVID-19 mental health informal caregivers. Methods: Eighty-seven centers evenly distributed territory...
Abstract The aim of this study was to investigate the role Brain Derived Neurotrophic Factor (BDNF) and inflammatory factors in development cognitive dysfunctions Multiple Sclerosis (MS). We correlated peripheral blood mononuclear cell (PBMC) production BDNF, Tumor Necrosis Factor‐alpha (TNF‐α), Interleukin (IL)‐6 IL‐10 with performances on specific neuropsychological tasks a selected series MS patients. studied sample 30 patients relapsing‐remitting (RR)MS, segregated by gender matched for...
Abstract Huntington's disease (HD) produces debilitating motor abnormalities that are poorly responsive to medical therapy. Deep brain stimulation (DBS) of the posteroventral globus pallidus internus (GPi) may offer a treatment option for patients with diskinetic phenotype and minimal cognitive impairment, but its role in management HD remains unclear date only two cases have been reported. We report outcome GPi‐DBS 72‐year‐old man HD. Stimulation at 130 Hz caused rapid amelioration chorea...
Aim of this study was to explore the EEG functional connectivity in amnesic mild cognitive impairments (MCI) subjects with multidomain impairment order characterize Default Mode Network (DMN) converted MCI (cMCI), which Alzheimer’s disease (AD), compared stable (sMCI) subjects. A total 59 were recruited and divided -after appropriate follow-up- into cMCI or sMCI. They further linguistic domain (LD) executive (ED) impairment. Small World (SW) index measured as balance between integration...
Objective: To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training for treatment symptoms in patients Alzheimer's Disease (AD). A secondary objective was to analyze associations between brain plasticity and effects treatment. Methods: In this randomized, sham-controlled, multicenter clinical trial, 34 AD were assigned three experimental groups receiving 30 daily sessions combinatory intervention. Participants real/real group (n=16)...
Semantic and, to a lesser extent, phonological verbal fluency tasks are impaired in Alzheimer's disease (AD) and amnesic mild cognitive impairment (aMCI). Furthermore, both have been considered as possible markers of conversion from
Background: The assessment of semantic memory may be a useful marker to identify individuals with mild cognitive impairment (MCI) who will progress Alzheimer’s disease (AD) in the early stages disease. Objective: aim this five-year follow-up longitudinal study is assess whether could predict progression MCI. Methods: A population MCI (N = 251); 178) and moderate AD 114); sample healthy participants (HP; N 262) was investigated. group completed by 178 patients. Semantic episodic measures were...
We administered to large groups of patients with neoplastic or degenerative damage affecting the right left ATL, 'Famous People Recognition Battery' (FPRB), in which subjects are required recognize same 40 famous people through their faces, voices and names, clarify components recognition lateralized. At familiarity level, we found, as expected, a dissociation between greater impairment ATL lesions on non-verbal (face voice) modalities those name familiarity. Equally expected were results...
Abstract Background The Italian Interceptor project is aimed at identifying a prodromal dementia phase and developing nationwide organizational model. This study compares the sociodemographic neuropsychological characteristics of mild cognitive impairment non‐converters (MCI‐NC) MCI‐converters (MCI‐C) to dementia, including Alzheimer's disease (AD), enrolled during project. Methods Sociodemographic, clinical, data MCI individuals were collected baseline (December 2018 October 2020) every...