A5072393749- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology of Language and Bilingualism
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Spatial Neglect and Hemispheric Dysfunction
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Diet and metabolism studies
- S100 Proteins and Annexins
- Reading and Literacy Development
- Neurological Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neural and Behavioral Psychology Studies
- Glioma Diagnosis and Treatment
- Obsessive-Compulsive Spectrum Disorders
- Language Development and Disorders
- Obstructive Sleep Apnea Research
- Acute Ischemic Stroke Management
Vita-Salute San Raffaele University
2015-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2007-2024
San Raffaele University of Rome
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2024
Fondazione Santa Lucia
2022
Fondazione IRCCS Istituto Neurologico Carlo Besta
2007-2022
University of Geneva
2022
Centro San Giovanni di Dio Fatebenefratelli
2022
Istituto Universitario di Studi Superiori di Pavia
2022
Cognitive Neuroimaging Lab
2021
Functional imaging methods show differences in the pattern of cerebral activation associated with subject's native language (L1) compared a second (L2). In recent PET investigation on bilingualism we showed that auditory processing stories L1 (Italian) engages temporal lobes and temporoparietal cortex more extensively than L2 (English). However, study Italian subjects learned late attained fair, but not an excellent command this (low proficiency, acquisition bilinguals). Thus, different...
Primary progressive aphasia (PPA) is characterized by isolated decline in language functions. Semantic dementia and nonfluent are accepted PPA variants. A "logopenic" variant (LPA) has also been proposed, but its cognitive anatomic profile less defined. The aim of this study was to establish the features LPA.Six previously unreported LPA cases underwent extensive neuropsychological evaluation an experimental phonological loop functions, including auditory visual span tasks with digits,...
FUNCTIONAL magnetic resonance imaging was used to assess inter-subject variability in the cortical representation of language comprehension processes. Moderately fluent French-English bilinguals were scanned while they listened stories their first (L1 = French) or a second (L2 English) acquired at school after age seven. In all subjects, listening L1 always activated similar set areas left temporal lobe, clustered along superior sulcus. Listening L2, however, highly variable network and...
[18F]-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) is a widely used diagnostic tool that can detect and quantify pathophysiology, as assessed through changes in cerebral glucose metabolism. [18F]-FDG PET scans be analyzed using voxel-based statistical methods such Statistical Parametric Mapping (SPM) provide maps of brain abnormalities single patients. In order to perform SPM, "spatial normalization" an individual's scan required match reference template. The template...
Diagnostic accuracy in FDG-PET imaging highly depends on the operating procedures. In this clinical study dementia, we compared diagnostic at a single-subject level of a) Clinical Scenarios, b) Standard FDG Images and c) Statistical Parametrical (SPM) Maps generated via new optimized SPM procedure. We evaluated added value FDG-PET, either or Maps, to Scenarios. 88 patients with neurodegenerative diseases (Alzheimer's Disease—AD, Frontotemporal Lobar Degeneration—FTLD, Dementia Lewy...
Previous reports have shown that higher education is associated with more severe brain pathology in patients Alzheimer disease (AD), suggesting these individuals a functional reserve provided by education, which masks the clinical expression of degree neurodegeneration. It unknown if similar mechanism exists amnestic mild cognitive impairment (aMCI). The aim this study was to assess impact and occupation on glucose metabolism (rCMRglc) measured FDG-PET aMCI very large sample subjects...
The anatomical correlates of tactile and visual extinction with double simultaneous stimulation were investigated in a series 159 patients right brain damage caused by stroke. Forty six showed (22 tactile, 14 visual, 10 visual). Over 50% the had deep lesions, which found about 25% visuospatial neglect not associated extinction. In cortico-subcortical paraventricular occipital white matter dorsolateral frontal cortex most often involved. By contrast, when was also present, lesions clustered...
We have studied 5 patients with unilateral, severe chronic pain due to cancer before and after percutaneous, ventrolateral cervical cordotomy investigate the central effects of procedure. The aim was identify functional anatomical correlates abolishing unilateral nociceptive input brain. Patients were investigated by positron emission tomography using C15O2 evaluate cerebral blood flow. Comparisons made between normal volunteers. These demonstrated significantly less flow in 3 out 4...
Orbitofrontal metabolic impairment is characteristic of the frontal variant frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types behavioral disturbances have been distinguished fv-FTD patients: apathetic disinhibited manifestations. In this study, we searched for relationships between brain metabolism presence or behavior. Metabolic activity data were collected 41 patients from European PET centers. A conjunction analysis showed an expected...
Cortical regional cerebral perfusion was assessed by N, N1-trimethyl-N1-(2)-hydroxy-3-methyl-5-(I-123) iodobenzyl-1, 3-propanediamine 2 HCl I-123 (HIPDM) and single photon emission computerised tomography (SPECT) in six aphasic two neglect patients with unilateral subcortical vascular lesions. Assessments were carried out both the acute phase after a period ranging from 1 to 6 months stroke onset. In all an almost complete spontaneous recovery occurred associated significant improvement of...
Abstract We explored the neural substrate of anosognosia for cognitive impairment in Alzheimer's disease (AD). Two hundred nine patients with mild to moderate dementia and their caregivers assessed patients' by answering a structured questionnaire. Subjects rated 13 domains as not impaired or associated mild, moderate, severe, very severe difficulties, sum score was calculated. measures were derived. A patient's self assessment, unconfounded objective measurements deficits such severity...
In this multicentre study in clinical settings, we assessed the accuracy of optimized procedures for FDG-PET brain metabolism and CSF classifications predicting or excluding conversion to Alzheimer's disease (AD) dementia non-AD dementias. We included 80 MCI subjects with neurological neuropsychological assessments, scan measures at entry, all follow-up. data were analysed a validated voxel-based SPM method. Resulting single-subject maps classified by five imaging experts according...
[(18)F]FDG-PET imaging has been recognized as a crucial diagnostic marker in Mild Cognitive Impairment (MCI), supporting the presence or exclusion of Alzheimer's Disease (AD) pathology. A clinical heterogeneity, however, underlies MCI definition. In this study, we aimed to evaluate predictive role single-subject voxel-based maps [(18)F]FDG distribution generated through statistical parametric mapping (SPM) progression different dementia subtypes sample 45 MCI. Their scans were compared large...